Biological Sciences
Master: José Quintans, BSLC 300, 702-7964, qui4@midway.uchicago.edu
Senior Adviser: Manfred D. E. Ruddat, EBC 010, 702-8796, mruddat@uchicago.edu
Administrative Assistant: Kila Roberts, BSLC 328, 702-7962, kila@uchicago.edu
Laboratory Manager: Marcia A. Gilliland-Roberts, BSLC 336, 702-1930, mroberts@yoda.bsd.uchicago.edu
Staff Secretary: BSLC 301, 702-7963
Administrator, Howard Hughes Medical Institute Programs:
Darby James, BSLC 303, 834-7744, jamesd@uchicago.edu
Faculty Advisers:
Doug Bishop, Genetics, CLSC 821B, 702-9211;
Martin Feder, Organismal Biology & Anatomy, A 201, 702-8096;
Bana Jabri, Immunology Specialization, AMB S352;
Gayle Lamppa, Molecular Genetics & Cell Biology, CLSC 827A,
702-9837;
Phillip Lloyd, Neuroscience Specialization, SBRI J45, 702-6376;
Marvin W. Makinen, Biochemistry & Molecular Biology, CLSC 439B, 702-1080;
Manfred D. E. Ruddat, Ecology & Evolution, EBC 010, 702-8796;
Olaf Schneewind, Microbiology Specialization, CLSC 601, 834-9060
Undergraduate Research and Honors: Deborah J. Nelson, Ab 506A,
702-0126, dnelson@drugs.uchicago.edu
Summer Undergraduate Research: Paul Strieleman, BLSC 338, 702-5076, pstriele@midway.uchicago.edu
Program of Study
Biology is the study of living things and their adaptations to the pressures of natural selection. The faculty of the College believes that a sound knowledge of biology is essential for understanding many of the most pressing problems of modern life and for intelligent involvement in their eventual solution. The Biological Sciences Collegiate Division, therefore, provides a variety of general education courses for all College students—prospective biologists and nonbiologists alike. Although most of the course offerings beyond the introductory year are designed to serve the needs of students majoring in biological sciences, many of these courses are well suited to students in other areas who wish to study some aspect of modern biology in greater detail. Courses on the ethical and societal implications of the biological sciences, for example, are of interest to all students.
The General Education Requirement
in the Biological Sciences
Students choose one of the following options to meet the general education requirement for the biological sciences:
(1) an integrated Natural Sciences sequence for nonmajors, covering all general education requirements in the physical and biological sciences; or
(2) a two-quarter general education sequence for nonmajors; or
(3) a Fundamentals Sequence required for students majoring in biological sciences and students preparing for the health professions.
Advanced Placement Credit. For students who do not plan to major in the biological sciences or prepare for the health professions, a score of 4 or 5 on the AP biology test confers credit for BIOS 10110. These students complete the general education requirement with either one or two topics courses in the biological sciences, depending on how the requirements in the mathematical and physical sciences are satisfied; consult your College adviser for details.
Students with a score of 5 on the AP biology test who complete an AP 5 Fundamentals Sequence will be awarded a total of two quarters of credit for the general education requirement. This option is especially appropriate for students who plan to major in the biological sciences or prepare for the health professions, but it is open to all qualified students.
Biological Sciences Writing Program. The Biological Sciences Writing Program is designed to assist both professors and students in biological sciences courses that are reading and writing intensive, using teaching assistants with both science- and humanities-based backgrounds to conduct writing workshops and discussion sections.
Requirements for the Biological Sciences Major
The goals of the biological sciences program are to give students (1) an understanding of currently accepted concepts in biology and the experimental support for these concepts, and (2) an appreciation of the gaps in our current understanding and the opportunities for new research in this field. Emphasis is placed on introducing students to the diversity of subject matter and methods of investigation in the biological sciences. The program prepares students for graduate or professional study in the biological sciences and for careers in the biological sciences. The following sections describe the requirements for a B.A. in the biological sciences.
General Education Courses for Biological Sciences Majors
To prepare for more advanced work in the biological sciences, students must take CHEM 11101-11201/11102-11202 (or equivalent) to meet the general education requirement in physical sciences; MATH 13100-13200 or higher to meet the mathematics requirement in general education; and two courses in a Fundamentals Sequence (BIOS 20181-20182 or 20191-20192) to meet the general education requirement in biological sciences. Students with a score of 5 on the AP biology test may use their AP credit to meet the general education requirement in biological sciences if the AP 5 sequence is completed.
Courses Required for the Biological Sciences Major
Courses in the Physical Sciences Collegiate Division
Biological sciences majors must complete the third quarter of general chemistry (CHEM 11301/11302 or equivalent); two quarters of organic chemistry (CHEM 22000-22100/23100); two quarters of physics (PHYS 12100-12200 or higher); one additional quarter of calculus (MATH 13300 or higher) or statistics (STAT 22000); and one additional course in mathematics, statistics (22000 or higher), CHEM 22200/23200, PHYS 12300 or higher, or an approved 20000-level physical science course.
Courses in the Biological Sciences
Fundamentals Sequence. Students register for the final three quarters of their Fundamentals Sequence (BIOS 20180s or 20190s) in the major, or for the three-quarter AP 5 Fundamentals Sequence if they have a 5 on the AP biology test.
20200-level and above Biological Sciences Courses. Students also register for Introduction to Biochemistry (BIOS 20200) plus five additional 20200-level and above courses in biological sciences. These five courses are selected by the student unless the student chooses to complete a "specialization," in which case three courses are stipulated by the specialization (see below).
NOTE: BIOS 00199, 00206, and 00299 may not be used to meet the requirements of the major. In most cases, courses listed under the heading "Specialized Courses" may not be used to meet the requirements of the major. Limited exceptions are specifically noted.
Summary of Requirements
General CHEM 11101-11201/11102-11202 or equivalent*
Education MATH 13100-13200, 15100-15200, or 16100-16200*
BIOS 20181-20182 or BIOS 20191-20192 or a 5 on the AP biology test if an AP 5 sequence is completed.
Major 3 BIOS 20234 and BIOS 20235** and one additional AP 5 sequence course or completion of BIOS 20180s or 20190s
1 CHEM 11301/11302 or equivalent*
1 BIOS 20200 (Biochemistry)
4-5 biological
sciences courses above 20200
(may include BIOS 00298)
2 CHEM 22000-22100/23100
2 PHYS 12100-12200 or higher*
1 MATH 13300, 15300, or 16300, or STAT 22000*
1 additional
course in mathematics (MATH 21500), statistics (STAT 22000 or higher),
CHEM 22200/23200, PHYS 12300 or higher,
or approved 20000-level
physical science course
15-16
* Credit may be granted by examination.
** Open only to students with a 5 on the AP biology test.
Grading. Students must receive quality grades in all courses in the major.
Research Opportunities. Students are encouraged to carry out individual guided research in an area of their interest. A student may propose an arrangement with any faculty member in the Biological Sciences Collegiate Division to sponsor and supervise research on an individual tutorial basis. Students register for BIOS 00199 or 00299 for course credit. Consult the course description section for information about procedures, grading, and requirements for registration in BIOS 00199 and 00299. For more information, see http://bscd.bsd.uchicago.edu/research.html.
Some financial support may be available to students with third- or fourth-year standing for summer research through their research supervisors or through fellowships awarded competitively by the Biological Sciences Collegiate Division.
Honors in Biological Sciences. Students may earn a bachelor's degree with honors in the biological sciences by satisfactorily completing an individual research program and honors thesis. To be eligible for honors, students must also have a GPA of 3.25 or higher overall and in courses in the major based on all course work up to the final quarter of graduation. Students are urged to consult with their advisers and with the director of the honors program well before their senior year for guidance on meeting the requirements for honors.
Honors students rarely begin their research later than the summer before their senior year; most honors students begin research in their junior year or earlier. Fourth-year students usually complete BIOS 00299 during Autumn and Winter Quarters and must complete BIOS 00298 in Spring Quarter. Students prepare oral and visual presentations of their research for a poster session early in Spring Quarter. Fourth-year students who wish to be considered for honors must submit a first draft of their thesis before the end of third week of Spring Quarter; it will be evaluated by two reviewers and returned to them with comments. The final version will then be due at the end of eighth week, and must be approved by the director of the honors program in consultation with the reviewers. For more information, see http://bscd.bsd.uchicago.edu/honorsprogram.html.
Specialization Programs in the Biological Sciences
Students who wish to complete a "specialization" should discuss their plans with the specialization chair in Spring Quarter of their second year.
Specialization in Cellular and Molecular Biology. Biological sciences majors who meet the following requirements will be recognized as having completed a specialization in the area of cellular and molecular biology.
The following requirements must be met:
Courses 1. third quarter of organic chemistry (CHEM 22200/23200)
2. three of the five 20200-level courses in the biological sciences that are required for the biological sciences major must be completed within the specialization, with one course each from three of the four following areas being selected:
a. BIOS
21207. Cell Biology
b. BIOS 21226. Genetics
c. BIOS 21227 or 23299. Developmental Biology
d. BIOS 21208 or 21209. Molecular Biology
Laboratory completion of an independent research project that
Research either:
1. qualifies as a senior honors project; or
2. is approved by the director of the specialization.
The specialization in cellular and molecular biology is administered by the Department of Molecular Genetics and Cell Biology. For more information, consult Gayle Lamppa (702-9837, gklamppa@midway.uchicago.edu).
Specialization in Ecology and Evolution. Biological sciences majors who complete the course work indicated below and meet the requirements of the senior honors paper will be recognized as having completed a specialization in ecology and evolution. This specialization is recommended for students who are interested in pursuing graduate work in the field or in laboratory sciences of ecology, evolution, population genetics, or behavior. Based on the student's particular interest, he or she will elect a faculty adviser, who then may recommend specific courses necessary to meet the specialization requirements (see following section). The faculty adviser may also help the student find an appropriate research laboratory in which to conduct an individual research project.
The following requirements must be met:
Courses 1. three quarters of calculus and three quarters of statistics (starting at the level of STAT 22000) in lieu of the physics requirement
2. three upper-level courses in the biological sciences, as recommended by the faculty adviser or the faculty member in whose lab the student does his/her research, from a menu of courses in ecology, evolution, genetics, or behavior
Laboratory completion of original research in the laboratory under the
or Field guidance of a member of the ecology and evolution
Research faculty, which will qualify the student to write an honors paper. NOTE: Students must complete field research by the end of the growing season (summer) of their third year.
The specialization in ecology and evolution is administered by the Department of Ecology and Evolution. For more information, consult Manfred Ruddat (702-8796, mruddat@uchicago.edu).
Specialization in Genetics. Biological Sciences majors who meet the following requirements will be recognized as having completed a specialization in the area of genetics.
The following requirements must be met:
Introductory 1. BIOS 20182 or 20192. Genetics (Winter) (students may not use
Courses AP credit to bypass)
2. BIOS 20185. Ecology and Evolution (Winter)
3. STAT 22000. Introductory Statistics with Applications
(section focused on Biological data)
Advanced 1. BIOS 21200. Human Molecular Genetics
Courses
Choose one of the following:
BIOS 21208. Fundamentals of Molecular Biology (Winter)
BIOS 21209. Molecular Biology (Winter)
BIOS 21306. Human Genetics and Evolution (Autumn)
BIOS 23256. Fundamentals of Molecular Evolution (Autumn)
Choose one of the following:
BIOS 21216. Introductory Statistical Genetics (Winter)
BIOS 21227. Advanced Developmental Biology (Autumn)
BIOS 23299. Plant Development and Molecular Genetics (Spring)
BIOS 25216. Molecular Genetic Analysis of Bacterial Pathogenesis (Spring)
BIOS 25307. Molecular Genetics of Bacteriophage (Spring)
Laboratory Completion of an independent research project.
Research The project must either:
Qualify as a senior honors project.
or
Be approved by the director of the specialization
The specialization in genetics is administered by the Committee on Genetics. Consult Doug Bishop (702-9211, dbishop@midway.uchicago.edu) for more information.
Specialization in Immunology. After taking the following three courses, biological sciences majors will be recognized as having completed a specialization in immunology. For those who wish further study, an elective is available to provide an in-depth understanding of key general immunological questions.
Required Courses
BIOS 25256. Immunobiology (Autumn)
BIOS 25257. Advanced Immunology (Winter)
BIOS 25258. Immunopathology (Spring)
Elective Course
BIOS 25259. Fundamental Issues in Immunology (Autumn)
For more information, consult Bana Jabri, Department of Pathology and the Committee on Immunobiology (834-8670, bjabri@bsd.uchicago.edu).
Specialization in Microbiology. Biological sciences majors who complete the following requirements will be recognized as having completed a specialization in microbiology. Students in this specialization are required to complete three quarters of organic chemistry. Students register for four required courses in the specialization (BIOS 25206, 25216, 25210, and 25286). Several electives are available to provide additional training in microbiology. With prior approval from the specialization chair, it may be possible to substitute one course from the list of suggested electives for one of the required courses.
Required Courses
BIOS 25206. Introduction to Bacterial Physiology (Autumn)
BIOS 25216. Molecular Genetic Analysis of Bacterial Pathogenesis
(Winter)
BIOS 25210. Experimental Physiology of Bacteria (Winter)
BIOS 25286. Viruses of Eukaryotes (Spring)
Electives in the Committee on Microbiology
BIOS 21307. Bacterial Genomes (Spring)
BIOS 25307. Molecular Genetic Analysis of Bacteriophage (Spring)
Honors Program in the Microbiology Specialization. Students who complete a research thesis have an opportunity to receive rigorous advanced training in microbiology and to receive honors. To graduate with honors in the biological sciences with a specialization in microbiology, students are required to (1) maintain a GPA of 3.25 or higher both overall and in the major, and (2) meet the lecture and laboratory course requirements of the specialization with a GPA of 3.25 or higher. They must also register for two research/reading courses (see below) and complete an experimental honors thesis project based on an experimental report covering at least two quarters of work in the laboratory of a faculty member of the Committee on Microbiology. The honors thesis paper and progress of the honors student in the final (fourth) year of study will be evaluated by a Committee of three faculty members assembled by the Chair of the Committee on Microbiology. Students interested in a research thesis should discuss their plans with the committee chair and enroll in 00199 (Undergraduate Research, Autumn Quarter), 00299 (Advanced Research in the Biological Sciences, Winter Quarter), and 00298 (Undergraduate Research Seminar, Spring Quarter).
For more information, students should consult with Dominique Missiakas, undergraduate adviser of the Committee on Microbiology (834-8161, dmissiak@bsd.uchicago.edu).
Specialization in Neuroscience. Biological sciences majors who complete the three required courses listed below will be recognized as having completed a specialization in neuroscience. Students who elect to specialize should consult the faculty adviser, Phillip Lloyd, who is available to advise on the choice of classes and to help identify laboratories in which individual research projects can be carried out. Students who plan to specialize are encouraged to begin the required sequence below in Spring Quarter of their second year, carry out individual guided research, participate in the honors research program, and attend neurobiology/biopsychology-related seminars.
BIOS 24204. Cellular Neurobiology
BIOS 24205. Systems Neuroscience
BIOS 24214. Cognitive Neuroscience
The following courses deal with topics of interest to neuroscientists. Students specializing in neuroscience may use these courses as electives to meet requirements for the major. Please note that the psychology courses meet requirements for the major only for students specializing in neuroscience.
BIOS 24207. Developmental Neurobiology
BIOS 24211. Neuroethology
BIOS 24217. Conquest of Pain
BIOS 24218. Molecular Neurobiology
BIOS 24221. Computational
Neuroscience I:
Single Neuron Computation
BIOS 24222. Computational Neuroscience II: Vision
BIOS 24223. Computational Neuroscience III: Language
BIOS 29405. Mathematical and Statistical Methods for Neuroscience I
BIOS 29406. Mathematical and Statistical Methods for Neuroscience II
BIOS 29407. Mathematical and Statistical Methods for Neuroscience III
PSYC 31000. Perspectives in Drug Abuse
PSYC 32000. Color Vision
PSYC 35000. Physiology of Vision
PSYC 38000. Seminar: Memory and Learning
PSYC 38700. Connectionist Modeling: Techniques
STAT 24700. Introduction to Probability Models
For more information, students should consult with Phillip Lloyd (702-6376, plloyd@uchicago.edu).
Minor Program in Computational Neuroscience
The minor in computational neuroscience is offered by the Biological Sciences Collegiate Division. Computational neuroscience is a relatively new interdisciplinary area of inquiry that is concerned with how components of animal and human nervous systems interact to produce behaviors. It relies on quantitative and modeling approaches to understand the function of the nervous system and to design human-made devices that duplicate behaviors. Course work in computational neuroscience can prepare students for graduate studies in neurobiology or psychology, in the mathematical or engineering sciences, or in areas of medicine such as neurology or psychiatry. It can lead to either traditional academic careers or to opportunities in the corporate world. Interested students may find more relevant information on computational neuroscience at the following Web site: http://cns.bsd.uchicago.edu.
This minor is a good option for students who are majoring in biological sciences and are interested in mathematical approaches to biology; or for students who are majoring in computer science, mathematics, physics, psychology, or statistics and are interested in neuroscience. Students electing this minor must have completed, or placed out of, the equivalent of a year of collegiate-level calculus, and must have completed the general education requirement for the biological sciences. A list of courses that are recommended to meet the general education requirement for the biological sciences can be found on the computational neuroscience Web site at: http://cns.bsd.uchicago.edu/index3.html?content=programinfo.html. This minor requires completion of the following two (three-course) sequences: BIOS 24221, 24222, 24223 (Computational Neuroscience I, II and III) and BIOS 29405, 29406, and 29407 (Mathematical and Statistical Methods for Neuroscience I, II, and III). Taking the two sequences concurrently is recommended but not required.
Students who elect the minor program are required to meet with the Chair of the Committee on Computational Neuroscience by the end of Spring Quarter of their third year. Students must obtain formal approval from the chair to complete the minor program on a form obtained from their College adviser and returned to the adviser by the deadline above. No courses in the minor can be double counted with the student's major(s) or with other minors; nor can they be counted toward general education requirements. More than half of the requirements for the minor must be met by registering for courses bearing University of Chicago course numbers. Students must earn a B- average or above in courses counted toward the minor.
Minor Program in Interdisciplinary Quantitative Studies
in the Natural Sciences
Offered by the Biological Sciences Collegiate Division, the minor in Interdisciplinary Quantitative Studies in the Natural Sciences is designed for third- and fourth-year majors in biology, chemistry, computer science, mathematics, and physics. The minor requires five courses: Computational Biology and four courses chosen from the list below.
Computational Biology, a course that carries 200 units of credit, introduces the interdisciplinary research and training expected of scientists in the twenty-first century. The other four required courses, which are chosen in consultation with the master of the Biological Sciences Collegiate Division, allow students to pursue either a specific area of interest or a range of interests. Students are required to meet with the master by the end of Spring Quarter of their third year to discuss a program of study. The master's approval for the minor program should be submitted to a student's College adviser by Spring Quarter of his or her third year on a form obtained from the adviser.
No course in the minor can be double counted with the student's major(s), with other minors, or with general education requirements. More than half of the requirements for the minor must be met by registering for courses bearing University of Chicago course numbers.
In addition to registering for the required introductory course described above, students choose four courses from the following list, which is subject to change.
BIOS 21216. Introductory Statistical Genetics
BIOS 21316. Biological Chemistry
BIOS 21318. Molecular Biophysics
BIOS 21319. RRP: Ribosomes, RNA, and Protein
BIOS 22242. Biological Fluid Mechanics
BIOS 22243. Biomechanics of Organisms
BIOS 24211. Neuroethology
BIOS 24221-24223. Computational Neuroscience
BIOS 26400. Introduction to Bioinformatics
BIOS 28500. Biological Physics
MATH 21400-21500. Biomathematics
Faculty
P. Amarasekare, Y. Amit, C. Andrews, P. Ashton-Rickardt, W. Barnhart, J. Bates,
A. Bendelac, J. Bergelson, D. Bishop, S. Boyle-Vavra, M. Brady, K. Cagney, M. Casadaban,
L. Casalino, M. Caserta, B. Chernoff, Z. Chi, K.-S. Chiang, A. Chong, T.
Christianson,
M. Coates, C. Correll, N. Cox, J. Coyne,
J. Crispino, E. DeSombre, H. de Wit, J. Dignam, A. DiRienzo, W. Du, V. Dukic,
G. Dwyer, W. Epstein, R. Esposito, M. E. Feder,
E. Ferguson, B. Fineschi, J. Flynn,
M. Foote, A. Fox, G. Franzoso, H. C. Friedmann,
T. Gajewski, G. Getz, M. Giger, D. Gillen, B. Glick, J. Goldberg, L. Goldman,
P. Goldstein,
W. Green, J. Greenberg, G. Greene,
E. Grove, M. Hale, K. Hamann, D. Hanck,
R. Haselkorn, N. Hatsopoulos, L. Heaney, A. Heller, R. Ho, W. Hoff, R. Hudson,
A. Hunter, N. Issa, D. Jablonski, B. Jabri, R. Josephs, M. Kearney, S. Kent, S.
Koide,
M. Kreitman, S. Kron, V. Kumar, M. LaBarbera, B. Lahn, G. Lamppa, E. Larsen,
D. Lauderdale, C. Lese-Martin, W.-H. Li, Y. Li, S. Liao, A. Lin, P. Lloyd, R.
E. Lombard,
M. Long, K. Macleod, P. Makovicky, D. Maestripieri, A. Mahowald, M. W. Makinen,
J. Malamy, D. Margoliash, S. Margulis, R. Martin, T. E. Martin, P. Mason, J.
Mateo,
M. McClintock, R. McCrea, J.
McElwain, D. McGehee, S. C. Meredith, L. Mets, K. Millen,
J. Milton, D. Missiakas, A. Montag, J. Moss, G. Mueller, P. Mueller, M. Musch,
J. Nachman, T. Nagylaki, P. Nash, D. Nelson, M. Nishimura, A. Noronha, C. Ober, M.
Osadjan,
C. Palfrey, T. Pan, S. Patel, B.
Patterson, I. Pavlova, R. Perlman, M. Peter, C. Pfister,
J. Piccirilli, D. Preuss, T. Price, V. Prince, S. Pruett-Jones, J. Quintans, C.
Ragsdale,
J.-M. Ramirez, P. Rathouz, I. Rebay, T. Regier, P. Rice, B. Roizman, M. Rosner, L. F. Ross,
L. Rothman-Denes, M. D. E. Ruddat, U. Schmidt-Ott, O. Schneewind, C. Schonbaum,
M. Schreiber, P. Schumacker, J.
Schwab, E. Schwartz, P. Sereno, J. Shapiro,
K. Sharma,
N. Shubin, P. Sierwald, H. Singh, S. Sisodia, T. Sosnick, A. Sperling, J.
Staley, T. Steck,
D. F. Steiner, U. Storb, F. H. Straus II, L. P. Straus, B. S. Strauss, P.
Strieleman, S. Szuchet,
W.-J. Tang, E. W. Taylor, G. Thinakaran, K. Thompson, A. Turkewitz, R. Tuttle,
P. Ulinski, L. M. Van Valen, M. Verp, P.
Vezina, M. Villereal, P. Wagner,
C.-R. Wang,
M. Westneat, W. Wimsatt, A. Wolfe,
T.-W. Wong, J. T. Wootton, C. Wu,
R. Zaragoza,
X. Zhuang, Y. Zou
Courses: Biological Sciences (bios)
Students must confirm their registration with their instructors by the second class meeting or their registration may be canceled. In the following course descriptions, L indicates courses with a laboratory.
Biological Sciences Sequences for Nonmajors
Students choose from the following options to meet the biological sciences requirement. The requirement should be completed by the end of the second year.
1. Students in this sequence take Biological Issues and Paradigms (BIOS 10110) as their first course. For their second quarter, students choose from a menu of topics courses (BIOS 10111-19999) that are comprehensive reviews of specialized topics in the biological sciences. Nonmajors are encouraged to enroll in additional biological sciences courses that cover topics of special interest to them.
BIOS 10110. Biological Issues and Paradigms. Students must confirm their registration with their instructors by the second class meeting or their registration may be canceled. This course addresses the question "what is life?" with a discussion of topics that range from the essential properties characteristic of all life to the complexities of evolution and interactions between all forms of life in the biosphere. Students in the course develop a broad common core of understanding of the nature of life through lectures, small group discussions, writing, and laboratory investigations. Laboratory fees apply. A second biology course (listed under "Topics Courses below") builds on this core knowledge, focusing on a specialized topic of biological inquiry. Autumn, Winter, Spring.
Multiple sections of this course are offered each quarter. Each section is taught from a different perspective by one of five faculty members based upon the specialty of the instructor. The Time Schedules will contain a "key descriptive word" in the notes for each section so students can register for the version that best suits their interests.
A. "From Molecules to Ecosystems" (key word: comprehensive) emphasizes how biological systems work, from macromolecules through cells and organisms to ecosystems. T. Christianson. Autumn, Spring.
B. "Current Issues in Biology" (key word: current) comprehensively covers modern biology. Subjects explored include current issues in genomics (the Human Genome Project), proteomics (the proteins the genome codes for), and stem cell biology. B. Fineschi. Autumn, Spring.
C. "Pharmacology Perspective" (key word: pharmacology) describes how drugs work at the cellular and organismal level, and covers advanced topics in cellular, molecular, and organismal biology. R. Zaragoza. Spring.
D. "Infectious Disease" (key word: infections) covers major concepts in biology (molecular biology, genetics, evolution) by focusing on the molecular basis of human diseases and the prevention and treatment of diseases such as HIV and cancer. I. Pavlova. Autumn, Winter.
E. "Organisms to Ecosystems" (key words: organisms, evolution, ecology) emphasizes evolution, ecology, and physiology with the use of readings from the primary literature as well as popular scientific publications. A. Hunter. Autumn, Winter.
F. "Quantitative Biology" (key word: quantitative) integrates mathematics with organismal, evolutionary, and ecological aspects of biology for science majors and students with prior knowledge of biology and basic mathematics skills. Students must perform well on the Biology Diagnostic Examination. E. Larsen. Winter.
2. "Nature of Life" (BIOS 10400/10401) is an alternative sequence to BIOS 10110 and a topics course. It is appropriate for students who are interested in a more chemical and molecular introduction to biology and who have a strong background in high school chemistry.
BIOS 10400. Molecular and Cellular Nature of Life. This course is the first in a sequence that is an alternative to BIOS 10110 for students interested in the more chemical and molecular aspects of biology. In this course, we examine the principles underlying the universal processes on which all forms of life, from humans to dandelions to bacteria, are based. We begin by discussing the fundamental chemical strategies that mediate energy conversion, coupling of metabolic pathways, and information storage and expression. With that understanding, we discuss crucial characteristics of life phenomena at the cellular level and then conclude the course with a look at the rapidly advancing field of genetic engineering and its far-reaching implications for our lives. K.-S. Chiang. Winter. L.
BIOS 10401. The Origin of Life. PQ: BIOS 10400. This course is the second in a sequence that is an alternative to BIOS 10110 for students interested in the more chemical and molecular aspects of biology. In this course, we discuss current thinking about the processes by which life emerged from just a few abiotic molecules and evolved into the present-day dazzling structural complexity characteristic of life. We begin by defining what is necessary and sufficient for life at its most basic level and discussing the fundamental chemical strategies that support life. With that understanding, we examine in some depth current theories and conjectures regarding chemical evolution and the emergence of the very first cell, the precursor to all life on the Earth. K.-S. Chiang. Spring.
Topics Courses for Nonmajors
The courses below have a prerequisite of BIOS 10100 or 10110, or a score of 4 or 5 on the AP biology test. Attendance is required at the first class to confirm enrollment.
11108. Human Heredity. PQ: BIOS 10100 or 10110. This course introduces the progress and problems in human genetics. Topics include genetic and physiologic determinants of sex, patterns of human inheritance, analysis of DNA and DNA fingerprinting, DNA cloning, prenatal genetic diagnosis, the genetics of complex traits, and the genetics of human populations. Assignments are based on current newspaper or magazine articles that reflect the interaction of genetics with some political, social, economic, or ethical issue. B. Strauss. Winter.
11109. Molecules to Cells and Back. PQ: BIOS 10100 or 10110. Selected topics of current medical and/or environmental interest are used to illustrate basic principles of cell and molecular biology. T. Martin. Spring.
11114. The Growth of Science. PQ: BIOS 10100 or 10110. This course attempts to show how the interdependence of observations and ideas leads to the development of scientific disciplines. Because the instructor is a biochemist, examples to some extent are selected from the development by men and by women of this field, whose vagaries provide opportune material for instructive generalizations that radiate into other biological and chemical areas. An attempt is made to determine reasons for the development and the lack of development of scientific disciplines at different times and in different places. H. Friedmann. Autumn.
11116. Genetic Engineering. PQ: BIOS 10100 or 10110. This course covers the history and technology of the efforts of humans to manipulate the genetic makeup of organisms. We focus most of our attention on genetic engineering in the production of agricultural, industrial, and medical products. We engage as a group in some virtual engineering projects. We also assess the ethical and public policy issues that are raised by rapid advances in genetic engineering technology. Field trips to sites where the work of genetic engineers is on display required. L. Mets. Spring.
11118. Introduction to Stem Cell Research. PQ: BIOS 10100 or 10110. This course examines the scientific progress and future research directions in stem cell biology, reviewing the current state of the science of stem cell research. We address stem cells from adult, fetal tissue, and embryonic sources, as well as research ethics and diseases. The current progress in identifying and defining stem cells is introduced. The underlying molecular circuitries supporting that stem cell maintenance and differentiation during development are discussed. Our goal is to convey knowledge in this particular field and serve as a platform for discussion sessions that develop the ability to generate original paradigms and concepts from the pool of preexisting ideas. E. Bertolino. Winter.
11119. The Biology of Gender. PQ: BIOS 10100 or 10110. This course explores the biological evidence and theories that seek to explain gender in humans. The course relies on current research in neuroscience, physiology, and cell biology to address such topics as the genetics of gender; sexual differentiation of the fetus; sexually dimorphic brain regions; the biology of gender identity and gender preference; and hormonal/environmental contributions to gender. M. Osadjan. Autumn.
11122. Topics in Environmental Biology. (=ENST 12402) PQ: BIOS 10100 or 10110, or consent of instructor. We consider interactions of H. sapiens with the natural environment at several biological levels: molecular, cellular, genetic, ecological, and human. T. Steck, A. Turkewitz. Winter.
11123. The X-Chromosome and its Degenerate Counterpart, the Y. PQ: BIOS 11108 or equivalent.Simplistic explanations of the biological basis of human sexuality rely on the qualitative/quantitatively different chromosomal constitution of males and females. Current biological research indicates that the situation is much more complex. This course considers the molecular structure of X and Y chromosomes and the control mechanisms that govern their function. Social consequences considered range from the use of the Y chromosome for the study of human history to the supposed roles of genes in homosexuality and in behavioral characteristics. B. Strauss. Spring.
12107. Cell Biology of Physiological Stress. PQ: BIOS 10100 or 10110. This course studies the application of cell biology principles to physiological stress. We use paradigms such as fasting to talk about organ interactions (e.g., the Cori cycle). This includes discussions of receptors, kinases, and other cellular biology. M. Musch. Autumn.
12108. Biology and the Human Condition. (=ENST 12108) PQ: BIOS 10100 or 10110. We discuss the insights that biology offers into some perennial human questions. Do the biological imperatives for reproduction and population growth inevitably conflict with the goals of a civilized society? Why do disease and suffering persist? In what ways are all people similar and in what ways is each individual unique? How do our genetic inheritances and our individual experiences interact in development? Is there a "human nature?" R. Perlman. Autumn.
12113. Human Physiology for Everyday Life. PQ: BIOS 10100 or 10110. Not open to students preparing for the health professions. Lecture topics cover all human body organ systems ranging from cardiovascular to reproductive in order to discuss the basic principles of human physiology. A special emphasis is placed on relating these physiologic principles to the common diseases one encounters in everyday life. T. Baman. Autumn.
12114. Nutritional Science. PQ: BIOS 10100 or 10110. This course examines the underlying biological mechanisms of nutrient utilization in humans and the scientific basis for setting human nutritional requirements. The relationships between food choices and human health are also explored. Students consider how to assess the validity of scientific research that provides the basis for advice about how to eat healthfully. Class assignments are designed to help students apply their learning by critiquing nutritional health claims and/or current nutrition policy issues. P. Strieleman. Spring.
13106. The Hungry Earth: Light, Energy, and Subsistence. (=ENST 13106) PQ: BIOS 10100 or 10110. This class considers the continuing erosion of the resources of the Earth by the persisting pressures of a growing human population, which makes a broad knowledge and appreciation of biology essential. Discussion includes the principles of energy conversion by plants as primary producers, the evolution of the structures and mechanisms involved in energy conversion, the origin of crop plants, improvements of plants by conventional breeding and genetic engineering, and the interactions of plants with pathogens and herbivores. M. Ruddat. Winter.
13107. Environmental Ecology. (=ENST 12404, NTSC 10400) PQ: BIOS 10100 or 10110. This course emphasizes basic scientific understanding of ecological and evolutionary principles that relate most closely to the ways humans interact with their environments. Topics include population growth, adaptation, and ecosystem structure and function. We also discuss the regulation and consequences of biodiversity. Discussion required. T. Price. Winter.
13109. Ecology. PQ: BIOS 10100 or 10110. Ecology is the study of the distribution and abundance of organisms. This course highlights key themes in ecology (e.g., how the environment affects species, evaluating the viability of populations, the implications for interactions among species, and the function of ecosystems). Emphasis is placed on how ecological information is being applied in the area of conservation biology. C. Pfister. Autumn.
13111. Natural History of North American Deserts. PQ: BIOS 10100 or 10110.This lecture/laboratory course focuses on the ecological communities of the Southwest, primarily on the four subdivisions of the North American Desert, the Chihuahuan, Sonoran, Mohave, and Great Basin Deserts. Lecture topics include climate change and the impact on the flora and fauna of the region; adaptations to arid landscapes; evolutionary, ecological, and conservation issues in the arid Southwest, especially relating to isolated mountain ranges; human impacts on the biota, land, and water; and how geological and climatic forces shape deserts. E. Larsen. Spring.
13112. Natural History of North American Deserts: Field School. PQ: Consent of instructor and concurrent enrollment in BIOS 13111.This lab course is a two-week field trip at end of Spring Quarter, specific dates to be announced. Our goal is to prepare proposals for field projects in the field portion of the course. Field projects are conducted at Organ Pipe Cactus National Monument in Arizona where we will compare patterns of plant and animal distribution along an elevation gradient in these two deserts. We then take a driving tour of the Mohave and Great Basin before returning to Chicago. Field conditions are rugged. Travel is by twelve-passenger van. Lodging during most of the course is tent camping on developed campsites. E. Larsen. Spring. L.
13118. Genetically Modified Organisms. PQ: BIOS 10100 or 10110. In this course, we discuss issues surrounding the production of genetically modified organisms. We begin by understanding genetic manipulation and how it can enhance agriculture and medicine. We then focus on critically evaluating the scientific basis of health and environmental concerns. Readings from the primary literature are supplemented with background information on genetic technologies and with presentations from the media. The class includes lectures, videos, student presentations, and extensive discussions. J. Bergelson. Winter.
13120. Economic Plants and Human Health. PQ: BIOS 10100 or 10110. The profound influence of plants on the economic development of human societies is based on their wide usage for food, medicine, and numerous other applications. We focus on plants that provide essential nutrients, medicines, and luxurious commodities, and on how agriculture and trade of plant products determines issues of world hunger and economic development. As a group, we explore alternative means of managing agricultural and medicinal plants to address problems of world hunger and economics. The class includes opportunities for field trips and hands-on experiences. I. Pavlova. Spring.
14107. Workings of the Human Brain. PQ: BIOS 10100 or 10110. This course is designed to give students an overview of the many functions of the brain, including perception, movement, language, emotion, memory, and sleep. We use a model of disease or dysfunction in an area of the brain to understand its normal functioning. This approach is complemented by presenting modern methods such as functional MRI and by reviewing historical milestones in neuroscience. Attendance required at each class meeting including lectures, labs, review sessions, and screenings of videotapes and imaging sessions. A. Noronha. Spring.
14108. Introduction to the Nervous System. PQ: BIOS 10100 or 10110. Extensive biology background not required but some knowledge of the field is helpful. This course is designed for students who are interested in learning the biology of the nervous system. Information is disseminated in the form of lectures that cover the basic principles and discussion sessions that illustrate specific examples. We cover compartments within the nervous system, development of different neuronal subtypes, neuronal connectivity, and neural activity in embryos and its role in sculpting neuronal connectivity. K. Sharma, Y. Zou. Autumn.
14109. Physiology of Addiction. PQ: BIOS 10100 or 10110. This course surveys the biological basis of substance abuse and substance addiction. We examine common addictions (e.g., caffeine, nicotine) to specialty drugs (e.g., ecstasy, anabolic steroids). Topics include: (1) an introduction to human metabolism and neurophysiology; (2) the mode of action of various substances on the nervous system; and (3) the storage, metabolism, and clearance of substances in the body. M. Osadjan. Winter.
15106. Plagues: Past and Present. PQ: BIOS 10100 or 10110. This course explores selected examples of ancient, re-emerging, and emerging pathogens in the context of biology, as well as epidemiology and the selective pressures that influence the spread and control of epidemics. Emphasis is placed on the biological basis of how microbes gain access to and cause damage in their hosts and the struggle between the pathogen and the host's immune system. Students also gain an understanding of the basis for diagnostic procedures, treatments, and immunization. Discussion sessions required in addition to lectures. S. Boyle-Vavra. Winter.
15108. Immune System in Health and Disease. PQ: BIOS 10100 or 10110. This class introduces basic concepts of molecular biology and immunology. Subjects include principles and applications of genetic engineering; defense mechanisms against infection and cancer; and various disorders of the immune system (e.g., allergy, autoimmunity, AIDS). C.-R. Wang. Winter.
15109. The Origins of Cancer. PQ: BIOS 10100 or 10110. In this lecture/discussion course, the molecular biology and clinical aspects of cancer are considered in tandem. In particular, the most prevalent malignant tumors (e.g., those arising in the breast, prostate, colon, and lung) are used as examples. T. W. Wong. Spring.
15111. Epithelium and Intestinal Flora. PQ: BIOS 10100 or 10110. This lecture/discussion course introduces the symbiotic relationship between humans and their intestinal flora on a cellular and molecular level. Special emphasis is given to understanding the benefits derived from normal gut flora as well as the molecular mechanisms responsible for diarrhea, inflammatory bowel disease, and cancer. Students discuss recent original experimental work in related fields. J. Sun, M. Hobert. Spring.
15112. Biological Poisons and Toxins. PQ: BIOS 10110 or 10100. This course explores biological poisons and toxins found throughout our environment. Toxins can originate from bacteria (anthrax, tetanus, botulinum, cholera), plants (ricin, curare, opiates), marine organisms (tetrodotoxin and saxitoxin), mushrooms (amanitin), frogs (batrachotoxin), and other organisms. Emphasis is placed on toxins that provide insight into the workings of the nervous, cardiovascular, and gastrointestinal systems. We also address current topics including the weaponization of toxins in biowarfare and bioterrorism and also explore examples of therapeutic (i.e., Botox) and commercial uses of toxins. J. Kyle. Spring.
15113. Viral Tricks. PQ: BIOS 10110 or 10100. Viruses are small obligate parasites of eukaryotic cells and bacteria. This course describes some very peculiar strategies that they adopt to maximize their replication. Viral structure and biology are addressed, with special attention to how viruses subvert the environment of the infected cell, render it more permissive to replication and neutralize the defenses of the infected cell/organism. L. Benetti. Spring.
15118. Why Microbes Know So Much Immunology. PQ: BIOS 10100 or 10110. This course discusses the interactions between microbes and their human and animal hosts from an evolutionary perspective. Particular emphasis is devoted to the plague, AIDS, anthrax, tuberculosis, and other major forms of pestilence. The ever-changing complex interactions between infectious agents and of innate and adaptive immunity are presented. J. Quintans. Winter.
Biological Sciences Sequences for Majors and
Students Preparing for the Health Professions
Five-Quarter Fundamentals Sequences
BIOS 20181 through 20185
This five-course sequence is an integrated introduction to the breadth of biology as a modern scientific discipline. It is designed for students who are preparing for a career in the biological sciences or medical professions. The material in this sequence is largely the same as that in the BIOS 20190s sequence. Topics include cell and molecular biology, genetics, developmental biology, organismal biology, and ecology and evolution. The final two quarters of this sequence must be completed by choosing two of the following three courses: BIOS 20184, 20185, or 20194. Students registering for this sequence must have completed or placed out of General or Honors Chemistry or be enrolled concurrently in General or Honors Chemistry. Students who completed the first three courses in this sequence prior to Autumn 2004 must complete two of the following courses: BIOS 20184 (Biodiversity), 20185 (Ecology and Evolution), or 20195 (Organismal Physiology [available Spring 2005 only]). Either BIOS 20183 (Physiology) or 20193 (Physiology), but not both, is also an option in fulfilling this requirement.
20181. Cell and Molecular Biology. This course is an introduction to molecular and cellular biology that emphasizes the unity of cellular processes amongst all living organisms. Topics are the structure, function, and synthesis of nucleic acids and protein; structure and function of cell organelles and extracellular matrices; energetics; cell cycle; cells in tissues and cell-signaling; altered cell functions in disease states; and some aspects of molecular evolution and the origin of cells. T. Martin, C. Schonbaum. Autumn. L.
20182. Genetics. PQ: BIOS 20181. The goal of this course is to integrate recent developments in molecular genetics and the human genome project into the structure of classical genetics. Topics include Mendelian inheritance, linkage, tetrad analysis, DNA polymorphisms, human genome, chromosome aberrations and their molecular analysis, bacterial and virus genetics, regulatory mechanisms, DNA cloning, mechanism of mutation and recombination, and transposable elements. D. Bishop, B. Lahn, P. Strieleman. Winter. L.
20183. Physiology. PQ: BIOS 20181 and 20182. This course focuses on the physiological problems that animals (including humans) face in natural environments; solutions to these problems that the genome encodes; and the emergent physiological properties of the molecular, cellular, tissue, organ, and organismal levels of organization. Lectures and labs emphasize physiological reasoning, problem solving, and current research. M. Feder, M. Osadjan. Spring. L.
20184. Biological Diversity. PQ: BIOS 20183 or 20193, or consent of instructor. An overview of the diversity of living organisms, both prokaryotes and eukaryotes, is presented. We emphasize the major groups of organisms, their evolutionary histories and relationships, and the biological and evolutionary implications of the characteristic features of each group. We discuss how the biosphere transformed to its present state over the past four billion years. M. LaBarbera, E. Larsen, A. Hunter, C. Andrews. Autumn. L.
20185. Ecology and Evolution. PQ: BIOS 20181-20182 or 20191-20192. This course surveys the major principles of ecology and evolutionary biology. Topics in evolutionary biology include the evidence for evolution, the history of life, the mechanisms of evolution (e.g., mutation, selection, genetic drift), adaptation, speciation, the origin of evolutionary novelties, the origin of life, and human evolution. Topics in ecology include demography and life histories, competition, predation, and the interspecific interactions that shape the structure of ecological communities. G. Dwyer, J. Coyne, C. Andrews. Winter. L.
BIOS 20191 through 20195
This integrated sequence examines the fundamental biological processes that are the basis of all life. Topics include cell and molecular biology, genetics, developmental biology, ecology and evolution, and organismal biology. The final two quarters of this sequence must be completed by choosing two of the following three courses: BIOS 20184, 20185, or 20194. Before registering for BIOS 20191, students must have completed or placed out of General or Honors Chemistry or they must have consent of instructor. Students who completed the first three courses in this sequence prior to Autumn 2004 must complete two of the following courses: BIOS 20184 (Biodiversity), 20185 (Ecology and Evolution), or 20195 (Organismal Physiology [available Spring 2005 only]). Either BIOS 20183 (Physiology) or 20193 (Physiology), but not both, is also an option in fulfilling this requirement.
20191. Cell and Molecular Biology. PQ: CHEM 11300 or 12300, or consent of instructor. The fundamental molecular processes of cells are examined using evidence from biochemical, physiologic, and microscopic analyses. Topics include the logical, spatial, and temporal organization and regulation of metabolism; the formation and function of proteins, RNA, and DNA; generation and function of cellular structures and compartments; regulation of gene expression; the organization and regulation of cell growth and division; and cell-environment and cell-cell interactions. L. Mets, B. Glick, C. Schonbaum. Autumn. L.
20192. Genetics. PQ: BIOS 20191. The goal of this course is to integrate recent developments in molecular genetics and the human genome project into the structure of classical genetics. Topics include Mendelian inheritance, linkage, tetrad analysis, DNA polymorphisms, human genome, chromosome aberrations and their molecular analysis, bacterial and virus genetics, regulatory mechanisms, DNA cloning, mechanisms of mutation and recombination, and transposable elements. G. Webb, C. Schonbaum, Staff. Winter. L.
20193. Organismal Physiology. PQ: BIOS 20191 and 20192. This course is concerned with fundamental physiological functions and their relation to structure. In multicellular organisms the responsibilities for preservation of an appropriate cellular milieu, substrate intake and metabolite excretion, circulation of substrates and metabolites, locomotion, and integration of function are achieved by specializations of cells into organs. The biological principles of organ development, interaction, regulation, and coordination to mediate survival of the organism are examined using models from simple multicellular organisms to humans. D. McGehee, M. Osadjan. Spring. L.
20194. Developmental Biology. PQ: First three quarters of either BIOS 20180s or 20190s. This course covers both the classical experiments that contributed to our understanding of developmental biology and the recent explosion of information about development made possible by a combination of genetic and molecular approaches. Examples from both vertebrate and invertebrate systems are used to illustrate underlying principles of animal development. J. Crispino, R. Ho, C. Schonbaum. Spring. L.
Three-Quarter AP 5 Fundamentals Sequence
(for students with a score of 5 on the AP biology test)
A score of 5 on the AP biology test, together with a sufficiently high score on the biology diagnostic exam, allows students to register for the three-quarter accelerated sequence below. For biological sciences majors, this sequence meets requirements for the major. Upon completion of the three-quarter AP 5 sequence, students will have three credits in the major and they will have met the general education requirement for the biological sciences. Students preparing for the health professions will have met the general education requirement and will have credit for three electives. All students must register for BIOS 20234 (Autumn Quarter) and BIOS 20235 (Winter Quarter). Students register for a third course chosen from the following list: BIOS 20243, 20244, 20249, 20256, 20257, or 20260.
20234. Molecular Biology of the Cell. PQ: AP 5 sequence and a sufficiently high score on the biology diagnostic exam. This course covers the fundamentals of molecular and cellular biology. Topics covered include: protein structure and function; DNA replication, repair and recombination; transcription, translation, and control of gene expression; cellular structure; organelles; cell cycle; cellular communication; cell movement. T. Pan, V. Prince, R. Zaragoza. Autumn. L.
20235. Biological Systems. PQ: BIOS 20234. This course builds upon molecular cell biology foundations to explore how biological systems function. Topics include classical and molecular genetics, developmental signaling networks, genomics, proteomics, transcriptomics, and biological networks. I. Rebay, T. Pan, R. Zaragoza. Winter. L.
20243. From Neurons to Behavior: The Morphological and Physio-logical Basis of Movement. PQ: Consent of instructor. This course meets requirements for the biological sciences major. This course examines movement systems at multiple levels of design and function integrating neurobiology, muscle morphology and physiology, skeletal mechanics, and the interaction of organisms with the physical environment. These topics are examined through lectures, readings from the primary literature, and labs. Lectures provide basics on each subject and examples of recently published work. Readings complement the lectures and cover current issues in the relevant fields. Labs involve exposure to methodological approaches and work on a class research project combining data collected with several of these techniques and pursuing the ultimate goal of publication. M. Hale. Spring. L.
20244. The BIO 2010 University of Chicago Initiative: Biophysics and Chemical Biology. PQ: First-year standing and a score of 5 on the AP biology test. This interdisciplinary seminar course is designed to prepare students for research at the interface between physical and biological sciences. Papers are drawn from recently published work of colleagues at the University of Chicago, allowing students to meet and interact with authors and to explore examples of approaches drawn from the physical sciences and applied as powerful tools to understand biological systems. Working in groups, the students master and critically review each paper, both in class and in essays. A lab section introduces core laboratories that provide researchers access to key technologies. S. Kron. Spring. L.
20249. Genome Informatics: Genome Organization, Expression, and Transmission. PQ: BIOS 20235. This seminar course examines how genomes are organized for coding sequence expression and transmission to progeny cells. The class discusses a series of key papers in the following areas: bacterial responses to external stimuli and genome damage, control of eukaryotic cell differentiation, complex loci regulating developmental expression in animals, centromere structure and function, position effect variegation, chromatin domains, chromatin remodeling, RNAi, and chromatin formatting. J. Shapiro. Spring.
20256. Developmental Genetics and Evolution. (=EVOL 33700, ORGB 33700) PQ: BIOS 20235. The purpose of this course is to provide a developmental genetic perspective on evolutionary questions that have emerged in various disciplines (e.g., developmental biology, paleontology, phylogenetic systematics). Topics range from the evolution of gene regulation to the origin of novelties (e.g., eyes, wings). These subjects are introduced in lectures, but emphasis is put on reading, presenting, and discussing original research papers. U. Schmidt-Ott. Spring.
20257. Experimental Biophysical Chemistry. PQ: BIOS 20235. This is an introductory, lab-based course directed towards studying binding interactions of macromolecules with metal ions, small molecule ligands, and other macromolecules. The strength of binding interactions of proteins and enzymes are measured using different physical methods to evaluate and compare quantitative limits of precision and accuracy in determining equilibrium binding constants. Emphasis is placed on error analysis. We apply state-of-the-art physical methods, including fluorescence, circular dichroism, differential scanning calorimetry, and surface plasmon resonance. The theory underlying physical methods used for experimental observation of macromolecular binding interactions is introduced in lectures. M. Makinen, M. Yousef. Spring. L.
20260. Chordate Evolutionary Biology. Chordate biology emphasizes the diversity and evolution of modern vertebrate life, drawing on a range of sources (from comparative anatomy and embryology to paleontology, biomechanics, and developmental genetics). Much of the work is lab-based, with ample opportunity to gain firsthand experience of the repeated themes of vertebrate bodyplans, as well as some of the extraordinary specializations manifest in living forms. Instructors, who are both actively engaged in vertebrate-centered research, take the course beyond the boundaries of standard textbook content. N. Shubin, M. Coates. Spring. L.
Advanced-Level Courses
There are three types of advanced courses. In courses listed under the heading General Courses, instructors present the general principles and recent developments for broad areas within the biological sciences. Such courses are usually offered on a regular basis, either annually or biennially. In courses listed under the heading Specialized Courses, the focus is on either a topic of particular interest to the instructor or on topics that are examined at a more advanced level than in General Courses. Such courses are offered less regularly, as warranted by student and faculty interest. Unless otherwise stated, most General Courses and Specialized Courses assume mastery of the material covered in the Fundamentals Sequences. Courses listed under the headings Specialized Courses and Independent Study and Research may not be counted toward the courses required for the major with the exception of BIOS 00298.
The following list provides information for students who are planning programs of study. Letters after course titles refer to the subject matter presented in the course: (C) Cell and Molecular, Genetics, or Developmental Biology; (CI) Computer Intensive; (E&E) Ecology and Evolution; (F) Fundamentals Sequence; (MIV) Microbiology, Immunology, or Virology; (N) Neuroscience; (S) Specialized; and (O) Organismal. L indicates courses with laboratory.
Autumn Quarter
20181. Cell and Molecular Biology. L. (F)