Contacts | Program of Study | General Education Requirements for the Biological Sciences | Advanced Placement Credit | Bachelor of Arts Degree in Biological Sciences | Biology Track | | Specialization Programs in the Biological Sciences | Interdisciplinary Biology Tracks | Ecology and Evolution Track | Global and Public Health Track | Computational Biology Track | Program Requirements for the Bachelor of Science in Biological Sciences | Honors | Research Opportunities | Minor in Biological Sciences | Grading and Academic Honesty | Biological Sciences (BIOS) Courses | Upper-level Elective Courses | Big Problems Courses | Specialized Courses | Independent Study and Research Courses | Graduate-Level Courses

Department Website: https://college.uchicago.edu/academics/biological-sciences-collegiate-division

Program of Study

Biology is the study of life, past and present. Our curriculum offers courses in many fields, from theoretical to experimental biology, and from molecular and genetic mechanisms underlying life to the complex interactions of organisms in ecosystems. As a major research institution, the University of Chicago focuses all courses in the Biological Sciences Collegiate Division on scientific reasoning, research, and discovery. The goals of the Biological Sciences curriculum are to give students (1) an understanding of currently accepted concepts in biology and the experimental support for these concepts, and (2) an appreciation of the gaps in our current understanding and the opportunities and tools available for new discoveries. A major in Biological Sciences can prepare students for careers in a wide range of areas, including health professions, basic or applied research in academia or industry, education, and policy related to human, animal, and planetary health.

Students can choose from multiple tracks to complete the Major in Biological Sciences:

Biology Track (BA and BS): Majors in the Biology Track take a series of foundational courses that span biological knowledge across fields and scales. They may then explore the breadth of biology with free electives to complete the major OR they may specialize in one area of biology through a focused selection of electives. Specializations are listed below and will be recognized on student transcripts (e.g., Biological Sciences – Specialization: Immunology). Research opportunities, internships, and courses at the Marine Biological Laboratory and Paris campuses are available for students in this track. See bscd.uchicago.edu for more information about research opportunities.

Paths through the Biology Track:

  1. Biological Sciences – No Specialization (free choice of BIOS electives)

  2. Biological Sciences – Cancer Biology Specialization

  3. Biological Sciences – Cellular and Molecular Biology Specialization

  4. Biological Sciences – Developmental Biology Specialization

  5. Biological Sciences – Endocrinology Specialization

  6. Biological Sciences – Genetics Specialization

  7. Biological Sciences – Immunology Specialization

  8. Biological Sciences – Microbiology Specialization

Interdisciplinary Biology Tracks (BA and BS): Increasingly, the biological sciences are incorporating knowledge and tools from physics, chemistry, computer science, statistics, public health, technological sciences, and the study of culture and society. Each Interdisciplinary Biology Track requires unique foundational courses that reflect these intersections. These tracks also allow students to choose electives from multiple departments to complete the major. Research opportunities, internships, and courses at the MBL and Paris campuses are available for students in these tracks. Interdisciplinary tracks are available in the following areas and will be recognized on student transcripts (e.g., Biological Sciences – Interdisciplinary Focus: Global and Public Health).

Interdisciplinary Biology Tracks:

  1. Biological Sciences – Ecology and Evolution
  2. Biological Sciences – Global and Public Health
  3. Biological Sciences – Computational Biology

Several types of degrees can be earned in all tracks:

Bachelor of Arts (BA): The BA is designed for students who wish to gain extensive training in the field of biology but also retain the flexibility to take elective courses outside the major. Scientific research is required for some tracks, but a thesis is not required to obtain a BA (although a thesis is required for some specializations; see details below).

Bachelor of Science (BS): The BS is designed for students who wish to delve more deeply into the field of their major through additional electives and completion of a BS thesis. Successful BS students will (1) learn how scientists design and conduct scientific experiments; (2) collect data as part of a research effort; (3) evaluate the strengths and weaknesses of that data; (4) interpret the data in the context of a specific scientific discipline; and (5) describe their work in a BS Thesis.

Bachelor of Arts/Bachelor of Science with Research Honors (Research Honors): Biology Research Honors is reserved for students who excel in the coursework of the major and have completed original research of high quality suitable for inclusion in a professional publication. Successful Research Honors students will (1) gain a scholarly understanding of a specific area of biology; (2) conduct scientific experiments, collect original data, analyze that data using appropriate statistics, and evaluate the strengths and weaknesses of the data; (3) interpret their findings in the context of their field; (4) describe their work in an Honors Thesis; and (5) present and defend their work in an oral presentation. 

Bachelor of Arts/Bachelor of Science with Scholar Honors (Scholar Honors): Scholar Honors recognizes exceptional academic performance including submission and acceptance of a scholarly thesis. 

General Education Requirements for the Biological Sciences

Students in all tracks must take 200 units of Biological Sciences, 200 units of Mathematics, and 200 units of Chemistry from the selected list described below. 

Biological Sciences General Education Courses

Students majoring in Biological Sciences choose one of the following options:

BIOS 20153Fundamentals of Ecology and Evolutionary Biology100
AND
BIOS 20151Introduction to Quantitative Modeling in Biology100
or BIOS 20152 Introduction to Quantitative Modeling in Biology (Advanced)

OR

A score of 4 or 5 on the AP Biology test AND three quarters of the Advanced Biology Fundamentals Sequence (BIOS 20234-20236) (see Advanced Placement Credit below).

BIOS 20234Molecular Biology of the Cell100
BIOS 20235Biological Systems100
BIOS 20236Biological Dynamics100

A score of 4 or 5 on the AP Biology test will fulfill the general education requirement in the biological sciences ONLY for students who complete three quarters of the Advanced Biology Fundamentals Sequence.

Note: There are two additional options for completing the general education requirement for students who are NOT Biological Sciences majors:

1. A two-quarter general education sequence for non-majors

2. The Health Professions Preparation Sequence for Non-Majors (BIOS 20170 Microbial and Human Cell Biology-BIOS 20175 Biochemistry and Metabolism)

Mathematics General Education Courses

Students majoring in Biological Sciences choose one of the following options:

MATH 13100-13200Elementary Functions and Calculus I-II200
MATH 15100-15200Calculus I-II200
MATH 16100-16200Honors Calculus I-II200

Chemistry General Education Courses

Students majoring in Biological Sciences choose one of the following options:

CHEM 10100
  &  10200
Introductory General Chemistry I
   and Introductory General Chemistry II
200
CHEM 11100-11200Comprehensive General Chemistry I-II200
CHEM 12100
  &  12200
Honors General Chemistry I
   and Honors General Chemistry II
200

Advanced Placement Credit

Students with a score of 4 or 5 on the AP Biology test who complete the first three quarters of the Advanced Biology Fundamentals Sequence will be awarded three credits toward the Biological Sciences major and credit for completing the general education requirement in the Biological Sciences. This option is especially appropriate for students who plan to major in Biological Sciences and prepare for a career in research, but it is open to all qualified students. 

Bachelor of Arts Degree in Biological Sciences

All Tracks require students to take 1600 units.

The basic degree in Biological Sciences is the BA. Students can qualify for a BA by following one of several tracks: 

1)  Biology Track – Provides a comprehensive education in biology across scales, focusing on the research that leads to discovery.  Students may explore the breadth of biological science or choose to specialize in a particular area.

2)  Interdisciplinary Track – Ecology and Evolution – Provides an in-depth education in ecology and evolution through course work, field work, advanced statistical skills, and research. Coursework opportunities at the Marine Biological Laboratory are particularly suited for this track.

3)  Interdisciplinary Track – Global and Public Health – Provides a cross-cutting education through coursework and research in the biology of disease, as well as economic and social factors influencing health outcomes worldwide. Coursework offered in Paris is particularly suited for this track.

4) Interdisciplinary Track – Computational Biology – Provides an interdisciplinary education in biology and the design and use of computational tools that can be used to address biological questions.

To qualify for a BA in one of these tracks, students must satisfy the general education requirements in biology, chemistry, and mathematics as described above AND:

1)  complete the required foundational courses, termed “Fundamentals Sequence”, for the track chosen;

2)  complete the required physical and mathematical sciences courses for the track chosen;

3)  complete appropriate upper-level electives for the track chosen.

Biology Track

Fundamentals Sequence Requirement

Students completing the major in the Biology Track will choose one of the following Fundamentals sequences:

1.  Fundamentals of Biological Science sequence—begins in the Winter Quarter of the first year and is structured to provide students with a broad-based understanding of contemporary biology. Note that BIOS 20151 Introduction to Quantitative Modeling in Biology/BIOS 20152 Introduction to Quantitative Modeling in Biology (Advanced), and BIOS 20153 Fundamentals of Ecology and Evolutionary Biology fulfill the general education requirement in biological sciences and are not counted towards the major.

BIOS 20151Introduction to Quantitative Modeling in Biology *# 100
or BIOS 20152 Introduction to Quantitative Modeling in Biology (Advanced)
BIOS 20153Fundamentals of Ecology and Evolutionary Biology *#100
BIOS 20186Fundamentals of Cell and Molecular Biology100
BIOS 20187Fundamentals of Genetics100
BIOS 20188Fundamentals of Physiology100
BIOS 20189Fundamentals of Developmental Biology100
BIOS 20200Introduction to Biochemistry100

2. Advanced Biology sequence—begins in the Autumn Quarter of first year and requires a high level of preparedness in Biology as well as a deep interest in research. The sequence is open to students who have achieved a score of 4 or 5 on the AP Biology test or by consent.+ Students seeking consent should contact Michael Glotzer (mglotzer@uchicago.edu).

BIOS 20234Molecular Biology of the Cell100
BIOS 20235Biological Systems100
BIOS 20236Biological Dynamics100
BIOS 20188Fundamentals of Physiology100
BIOS 20200Introduction to Biochemistry100

After completion of three quarters of a Fundamentals Sequence, students begin taking upper-level elective courses in the biological sciences and may start a specialization.

Physical and Mathematical Sciences Requirement

Students completing the major in the Biology Track are required to take courses in mathematical and physical sciences as follows:

PHYSICAL SCIENCES. All of the following:
CHEM 11300Comprehensive General Chemistry III (or equivalent)100
CHEM 22000
  &  22100
Organic Chemistry I
   and Organic Chemistry II (or higher)
200
PHYS 12100-12200General Physics I-II (or higher)200
MATHEMATICAL SCIENCES. One of the following:
BIOS 26210Mathematical Methods for Biological Sciences I100
PHYS 12300General Physics III (or higher)100
STAT 22000Statistical Methods and Applications100

NOTE 1: The Biology Track does NOT require the third quarter of calculus. Students MUST take BIOS 20151 Introduction to Quantitative Modeling in Biology (Basic) or BIOS 20152 Introduction to Quantitative Modeling in Biology (Advanced), and students in the Advanced Biology sequence MUST take BIOS 20236 Biological Dynamics. NO Mathematics courses may be substituted for these requirements.

NOTE 2: Students planning to apply to medical school should be aware of individual medical school admissions requirements and should tailor their program accordingly with the help of UChicago Careers in Healthcare

Upper-Level Elective Requirements

Students completing the major in the Biology Track must take five upper-level courses (course numbers BIOS 21000 to 28999) to complete the Bachelor of Arts degree. These courses may be selected by the student or in consultation with the BSCD Senior Advisers (Megan McNulty, mmcnulty@uchicago.edu; Chris Andrews, candrews@uchicago.edu). 

If the student following the Biology Track chooses to focus their coursework in a specific area, they can complete a specialization. In this case, courses should be chosen in consultation with the specialization adviser (listed below). 

NOTE: BIOS 00199 Undergraduate Research, BIOS 00206 Readings: Biology, and BIOS 00299 Advanced Research: Biological Sciences may not be used to meet requirements for the Biological Sciences degree. 

Summary of Requirements for a BA in Biological Sciences: Biology Track 

CHEM 11300Comprehensive General Chemistry III (or equivalent)100
CHEM 22000
  &  22100
Organic Chemistry I
   and Organic Chemistry II (or higher)
200
PHYS 12100-12200General Physics I-II (or higher)200
One of the following general quantitative courses:100
Mathematical Methods for Biological Sciences I
General Physics III (or higher)
Statistical Methods and Applications
Fundamentals of Biological Science Sequence or Advanced Biology Sequence500
Five upper-level electives in Biological Sciences, BIOS 21000-28999500
Total Units1600

Specialization Programs in the Biological Sciences

Specializations represent recommended programs of study for students interested in one particular field within the biological sciences. Students who wish to complete a specialization should discuss their plans with the specialization director by Spring Quarter of their second year. Students may complete only one specialization. All courses must be taken for a quality grade in order to count toward a specialization.

Specialization in Cancer Biology
Specialization in Cellular and Molecular Biology
Specialization in Developmental Biology
Specialization in Endocrinology
Specialization in Genetics
Specialization in Immunology
Specialization in Microbiology

NOTE: Beginning with the entering class of Autumn Quarter 2022, the Specializations in Global Health Sciences and Ecology and Evolution will no longer be available.* Beginning with the entering class of Autumn Quarter 2023, the Specialization in Quantitative Biology will no longer be available.**  Students interested in focusing their major coursework in one of these fields can pursue an Interdisciplinary Biology track in Global and Public Health, Ecology and Evolution, or Computational Biology.

Specialization in Cancer Biology

Students who complete the requirements detailed below will be recognized as having completed a Specialization in Cancer Biology.

To be eligible to carry out a Specialization in Cancer Biology, students must average a B grade in one of the Fundamentals Sequences.

Students who plan to specialize in cancer biology are advised to begin the required specialization courses in their second or third year in the College. Students who elect to specialize should email Dr. Kay F. Macleod (kmacleod@uchicago.edu), providing contact information, name and contact for your College adviser, a copy of your most recent grade transcript, and a half-page summary of why you are interested in the Specialization in Cancer Biology and what your long-term career goals are. An annual overview meeting is organized for the fall of each year at which advice will be provided on the objectives of the specialization, the importance of each of the courses, and guidelines on how to identify labs in which individual research projects can be carried out. Interested students are encouraged to attend and to bring forward any questions about requirements and research options at this meeting.

Course Work. The following courses are required for a Specialization in Cancer Biology. To continue in the specialization, students must achieve an A or a B grade in both courses.

BIOS 25108Cancer Biology100
BIOS 25308Heterogeneity in Human Cancer: Etiology and Treatment100

To complete the Specialization in Cancer Biology, students should also take one of the following two courses in either their third or fourth year, having successfully completed BIOS 25108 and BIOS 25308 above, and started work in their chosen research laboratory.

BIOS 25326Tumor Microenvironment and Metastasis100
BIOS 25327Health Disparities in Breast Cancer100

To complete the Specialization in Cancer Biology, students will also carry out individual guided research in a cancer research laboratory and attend cancer biology-related seminars. Participation in the research component of the Specialization in Cancer Biology is by invitation only and is based on:

(1) performance in the above-mentioned courses, (2) identification of a research project and mentor, (3) submission of a research abstract for consideration by the end of the Winter Quarter of their junior year to the Director of the Specialization in Cancer Biology (Dr. Kay Macleod).

Laboratory Research: Independent research projects performed by students in the Specialization in Cancer Biology must be approved by the Director of the Specialization (Dr. Kay Macleod) and to be of sufficiently high standard to qualify as a senior honors project and ideally to produce data that contributes to peer-reviewed publication.

Students are encouraged to begin their research project no later than the Spring/Summer Quarter of their junior year.

Specialization in Cellular and Molecular Biology

Biological Sciences majors can complete the Specialization in Cellular and Molecular Biology by either:

1. Successful completion of CHEM 22200 Organic Chemistry III or CHEM 23200 Honors Organic Chemistry III plus four upper-level BIOS courses selected from the list below.

OR

2. Successful completion of CHEM 22200 Organic Chemistry III or CHEM 23200 Honors Organic Chemistry III plus three upper-level BIOS courses selected from the list below and completion of a senior thesis on an independent research project. This project must either (1) satisfy the requirements for the BSCD Honors program, (2) satisfy the requirements for a BS in Biological Sciences, or (3) be approved by the directors of the specialization no later than Spring Quarter of the third year.

Please consult Chris Andrews (candrews@uchicago.edu) or Megan McNulty (mmcnulty@uchicago.edu) for approval of research projects or to request approval for any non-listed course with significant content in cellular and molecular biology.

Courses

BIOS 21236Genetics of Model Organisms100
BIOS 21237Developmental Mechanisms100
BIOS 21238Cell Biology II100
BIOS 21360Advanced Molecular Biology100
BIOS 21416Stem Cells and Regeneration100
BIOS 21510Chromatin & Epigenetics100
BIOS 23299Plant Development and Molecular Genetics100
BIOS 25226Endocrinology I: Cell Signaling100
BIOS 25266Molecular Immunology100
BIOS 27750Stem Cells and Regeneration: from aquatic research organisms to mammals100

Specialization in Developmental Biology

Students majoring in Biological Sciences who complete the requirements detailed below will be recognized as having completed a Specialization in Developmental Biology. 

The following requirements must be met:

1. Successful completion of BIOS 20189 Fundamentals of Developmental Biology or BIOS 20236 Biological Dynamics plus five upper-level courses selected from the list below.

OR

2. Successful completion of BIOS 20189 Fundamentals of Developmental Biology or BIOS 20236 Biological Dynamics plus three upper-level courses selected from the list below and completion of a senior thesis on an independent research project. This project must either (1) satisfy the requirements for the BSCD Honors program, (2) satisfy the requirements for a BS in Biological Sciences, or (3) be approved by the directors of the specialization no later than Spring Quarter of the third year.

Please consult Akira Imamoto (aimamoto@uchicago.edu) for approval of research projects or to request approval for any non-listed course with significant content in developmental biology.

Courses

Three of the following (with research thesis) or five of the following (without research thesis).

BIOS 21236Genetics of Model Organisms100
BIOS 21237Developmental Mechanisms100
BIOS 21356Vertebrate Development100
BIOS 21415Stem Cells in Development and Diseases100
BIOS 21416Stem Cells and Regeneration100
BIOS 21507Stem Cell Biology, Regeneration, and Disease Modeling100
BIOS 21510Chromatin & Epigenetics100
BIOS 22306Evolution and Development100
BIOS 23299Plant Development and Molecular Genetics100
BIOS 27724Introduction to Imaging for Biological Research100
BIOS 27750Stem Cells and Regeneration: from aquatic research organisms to mammals100
NSCI 22300Molecular Principles of Nervous System Development100

Specialization in Endocrinology

Students majoring in Biological Sciences who complete the requirements detailed below will be recognized as having completed a Specialization in Endocrinology. Students who complete the specialization will be well-versed in all aspects of endocrinology, ranging from basic cell signaling to the integration of endocrine systems and their dysregulation in human disease. Students must take three introductory courses listed below plus two additional courses from the elective list. The prerequisite for these courses is completion of the Fundamentals Sequence. It is strongly recommended that students complete a Biochemistry course before enrolling; however, the introductory courses can be completed as Endocrinology I–II-III or Endocrinology II-III-I. 

Introductory Courses

BIOS 25226Endocrinology I: Cell Signaling (Autumn)100
BIOS 25227Endocrinology II: Systems and Physiology (Winter)100
BIOS 25228Endocrinology III: Human Disease (Spring)100

Elective Courses

BIOS 22236Reproductive Biology of Primates100
BIOS 22249Principles of Toxicology100
BIOS 24248Biological Clocks and Behavior100
BIOS 25109Topics in Reproduction and Cancer100
BIOS 25126Animal Models of Human Disease100
PSYC 20300Biological Psychology *100
PSYC 25750The Psychology and Neurobiology of Stress *100

The Specialization in Endocrinology is administered by the Section of Endocrinology, Diabetes, and Metabolism, the Committee on Molecular Metabolism and Nutrition, and the NIH-funded Diabetes Research and Training Center. For more information, consult Matthew Brady (mbrady@medicine.bsd.uchicago.edu).

Specialization in Genetics

Students majoring in Biological Sciences who complete the requirements below will be recognized as having completed a Specialization in Genetics. Students must either:

1. Complete five courses from the categories listed below, including at least one from each category.

OR

2. Complete three courses chosen from the categories listed below, including one course in each category, and complete a senior thesis or an independent research project. This project must either (1) satisfy the requirements for the BSCD honors program, (2) satisfy the requirements for a BS in Biological Sciences, or (3) be approved by the directors of the specialization no later than Spring Quarter of the third year.

Please consult Chris Andrews (candrews@uchicago.edu) or Megan McNulty (mmcnulty@uchicago.edu) for approval of research projects or to request approval for any non-listed course with significant genetics content.

One of the following:
STAT 22000Statistical Methods and Applications (or higher)100
BIOS 21306Human Genetics and Evolution100
One of the following:
BIOS 21236Genetics of Model Organisms100
BIOS 23258Molecular Evolution I: Fundamentals and Principles100
One of the following with research or three of the following without research:
BIOS 21216Introduction to Statistical Genetics100
BIOS 21229Genome Informatics: How Cells Reorganize Genomes100
BIOS 21237Developmental Mechanisms100
BIOS 21510Chromatin & Epigenetics100
BIOS 22306Evolution and Development100
BIOS 23299Plant Development and Molecular Genetics100
BIOS 25216Molecular Basis of Bacterial Disease100
BIOS 25287Introduction to Virology (Spring)100
BIOS 25328Cancer Genetics and Genomics100
BIOS 28407Genomics and Systems Biology (Spring)100

Please consult Megan McNulty (mmcnulty@uchicago.edu) or Chris Andrews (candrews@uchicago.edu) for more information.

Specialization in Immunology

Students majoring in Biological Sciences will be recognized as having completed a Specialization in Immunology if they complete the following: (1) three of the four courses listed below, and (2) either two additional courses, selected in consultation with the director of the specialization, or a research project, approved by the director of the specialization. 

BIOS 25256Immunobiology (Autumn)100
BIOS 25258Immunopathology (Winter)100
One of the following:
BIOS 25266Molecular Immunology (Spring, offered every other year in odd years)100
BIOS 26403Quantitative Immunobiology (Winter)100

For more information, students should consult with the director of the specialization, Daria Esterhazy (desterhazy@bsd.uchicago.edu).

Accelerated Program in Immunology

The University of Chicago Graduate Program in Immunology permits undergraduate students who have demonstrated outstanding potential for graduate studies in biology to begin graduate school during their fourth year in the College. This is a competitive merit-award program.

Because of the accelerated nature of the curriculum, applicants must have outstanding academic credentials (i.e., GPA typically in the range of 3.7 and GRE scores typically not less than 1400). Eligible students also have a clear understanding of their motivation for immunology. Laboratory experience is not mandatory but highly encouraged.

Candidates will apply to the Graduate Program in Immunology at the University of Chicago during their third year in the College. Eligible students must have completed thirty-three credits (of the forty-two required for a degree in the College) by the end of their third year. These thirty-three credits must include all fifteen general education requirements and one-half of the requirements for their major.

For further information, contact the director of the specialization, Daria Esterhazy (desterhazy@bsd.uchicago.edu).

Specialization in Microbiology

Students majoring in Biological Sciences who complete the requirements detailed below will be recognized as having completed a Specialization in Microbiology. Students must take the three courses listed below and either two additional courses or a research project. With prior approval from the director of the specialization, students may substitute BIOS 25206 Fundamentals of Bacterial Physiology and BIOS 25216 Molecular Basis of Bacterial Disease with GEOS 26650 Environmental Microbiology and BIOS 27811 Global Health Sciences II: Microbiology

Students are encouraged to begin this sequence in Autumn Quarter of their third year, carry out individual guided research, participate in the honors research program, and attend the Microbiology Seminar series (micro.uchicago.edu/events).

For additional information, please contact the director of the specialization, Dominique Missiakas (dmissiak@bsd.uchicago.edu)

REQUIRED COURSES
BIOS 25206Fundamentals of Bacterial Physiology (Autumn)100
BIOS 25216Molecular Basis of Bacterial Disease (Winter)100
BIOS 25287Introduction to Virology (Spring)100
Total Units300
ELECTIVE COURSES
Two of the following:
BIOS 23409The Ecology and Evolution of Infectious Diseases100
BIOS 25207Fundamentals and Applications of the Human Microbiota100
BIOS 25256Immunobiology100
BIOS 25260Host Pathogen Interactions100
GEOS 26650Environmental Microbiology (Autumn)100
BIOS 27720Microbiomes Across Environments100
CHEM 22200Organic Chemistry III100

Interdisciplinary Biology Tracks

Ecology and Evolution Track

Fundamentals Sequence Requirement

Students completing the Biological Sciences major in the Ecology and Evolution Track must choose one of the following Fundamentals sequences:

1. Fundamentals of Ecology and Evolution sequence—begins in the Winter Quarter of the first year and is structured to provide students with a foundation for interdisciplinary study in this field. Note that BIOS 20151 Introduction to Quantitative Modeling in Biology/BIOS 20152 Introduction to Quantitative Modeling in Biology (Advanced) and BIOS 20153 Fundamentals of Ecology and Evolutionary Biology fulfill the general education requirement in biological sciences and are not counted towards the major.

BIOS 20151Introduction to Quantitative Modeling in Biology #100
or BIOS 20152 Introduction to Quantitative Modeling in Biology (Advanced)
BIOS 20153Fundamentals of Ecology and Evolutionary Biology #100
BIOS 20186Fundamentals of Cell and Molecular Biology100
BIOS 20187Fundamentals of Genetics100
BIOS 20198Biodiversity *#100

OR

2. Advanced Biology Ecology and Evolution Fundamentals sequence—begins in the Autumn Quarter of first year and requires a high level of preparedness in biology as well as a deep interest in research. The sequence is open to students who have achieved a score of 4 or 5 on the AP Biology test or by consent.+ Students seeking consent should contact Michael Glotzer (mglotzer@uchicago.edu).

BIOS 20234Molecular Biology of the Cell100
BIOS 20235Biological Systems100
BIOS 20236Biological Dynamics100
BIOS 20198Biodiversity100

Field Ecology Requirement

In addition, students following either the Fundamentals of Ecology and Evolution sequence or the Advanced Biology Ecology and Evolution Fundamentals sequence must complete the sequence with one of the following field ecology courses:

BIOS 20196Ecology and Conservation100
BIOS 27710Ecology - Marine Biological Laboratory (offered in the Semester in Environmental Science program at MBL) *100
BIOS 27751Biological Oceanography (offered in the Spring Quarter at MBL) *100
BIOS 27725Biogeography and Distribution of Species (offered in the September Term at MBL) *100

Physical and Mathematical Sciences Requirement

Students completing the Biological Sciences major in the Ecology and Evolution track must take:

CHEM 11300Comprehensive General Chemistry III (or equivalent)100
STAT 22000Statistical Methods and Applications100
One of the following:
CHEM 22000
  &  22100
Organic Chemistry I
   and Organic Chemistry II (or higher)
200
PHYS 12100-12200General Physics I-II (or higher)200
Three additional quantitative courses *300

*Students can satisfy this requirement with quantitative upper-level BIOS courses or courses from other departments (e.g., MATH, PHYS, STAT, or CMSC). Biological Sciences majors pursuing this track should confirm their quantitative course selections with Senior Biology Advisor Chris Andrews (candrews@uchicago.edu).

NOTE 1: The Ecology and Evolution Track does NOT require the third quarter of calculus. Students MUST take BIOS 20151 Introduction to Quantitative Modeling in Biology (Basic) or BIOS 20152 Introduction to Quantitative Modeling in Biology (Advanced), and students in the Advanced Biology sequence MUST take BIOS 20236 Biological Dynamics. NO Mathematics courses may be substituted for these requirements.

NOTE 2: Students planning to apply to medical school should be aware of individual medical school admissions requirements and should tailor their program accordingly with the help of UChicago Careers in Healthcare

Upper-Level Elective Requirements

Students completing the Biological Sciences major in the Ecology and Evolution Track must take five upper-level courses (BIOS 21000 to 28999) after the Fundamentals of Ecology and Evolution sequence to complete the Bachelor of Arts degree; three of these electives must be in the area of ecology, evolution, genetics, or behavior (notated with an E after the course title in the catalog). 

Four upper-level electives are required for students who have completed the Advanced Biology Ecology and Evolution Fundamentals sequence; three of these electives must be in the area of ecology, evolution, genetics or behavior (notated with an E after the course title in the catalog).

NOTE: BIOS 00199 Undergraduate Research, BIOS 00206 Readings: Biology, and BIOS 00299 Advanced Research: Biological Sciences may not be used to meet requirements for the Biological Sciences degree. Courses listed under the heading Specialized Courses (course numbers in the 29000 range) may not be used to meet requirements for the Biological Sciences degree.

Additional Requirements: Completion of the major through this track requires one quarter of independent field or research work in the area of Ecology and Evolution (approval of the Ecology and Evolution Track Director Cathy Pfister (cpfister@uchicago.edu) or Chris Andrews (candrews@uchicago.edu) is required).

Research opportunities of particular interest to students in this track can be found on the Interdisciplinary Biology Ecology and Evolution page. 

Summary of Requirements: Ecology and Evolution Track

CHEM 11300Comprehensive General Chemistry III (or equivalent)100
STAT 22000Statistical Methods and Applications100
One of the following:200
Organic Chemistry I
   and Organic Chemistry II (or higher)
General Physics I-II (or higher)
Three additional quantitative courses *300
Fundamentals of Ecology and Evolution Sequence or Advanced Biology Ecology and Evolution Sequence +300
Field Ecology Course100
Five courses, BIOS 21000-28999 in Biological Sciences (at least 3 notated E) +500
One quarter of approved research
Total Units1600

For further questions about this track please contact Ecology and Evolution Track Director Cathy Pfister (cpfister@uchicago.edu) or Chris Andrews (candrews@uchicago.edu). 

Global and Public Health Track

Fundamentals Sequence Requirement

Students completing the Biological Sciences major in the Global and Public Health Track must choose one of the following Fundamentals sequences:

1. Fundamentals of Global and Public Health sequence—begins in the Winter Quarter of the first year and is structured to provide students with a foundation for interdisciplinary study in this field. Note that BIOS 20151 Introduction to Quantitative Modeling in Biology/BIOS 20152 Introduction to Quantitative Modeling in Biology (Advanced) and BIOS 20153 Fundamentals of Ecology and Evolutionary Biology fulfill the general education requirement in the biological sciences and are not counted towards the major.

BIOS 20151Introduction to Quantitative Modeling in Biology *# 100
or BIOS 20152 Introduction to Quantitative Modeling in Biology (Advanced)
BIOS 20153Fundamentals of Ecology and Evolutionary Biology *#100
BIOS 20186Fundamentals of Cell and Molecular Biology100
BIOS 20187Fundamentals of Genetics100
BIOS 20188Fundamentals of Physiology100
BIOS 27810Epidemiology and Population Health: Global Health Sciences I **100

*# BIOS 20151/BIOS 20152 and BIOS 20153 fulfill the general education requirement in the biological sciences and are prerequisites for the rest of the courses in the Fundamentals Sequence. BIOS 20151 may be taken simultaneously with BIOS 20186.

OR

2. Advanced Biology Global and Public Health Fundamentals sequence—begins in the Autumn Quarter of the first year and requires a high level of preparedness in biology as well as a deep interest in research. The sequence is open to students who have achieved a score of 4 or 5 on the AP Biology test or by consent.* Students seeking consent should contact Michael Glotzer (mglotzer@uchicago.edu).

BIOS 20234Molecular Biology of the Cell100
BIOS 20235Biological Systems100
BIOS 20236Biological Dynamics100
BIOS 20188Fundamentals of Physiology100
BIOS 27810Epidemiology and Population Health: Global Health Sciences I **100

In addition, students following either the Fundamentals of Global and Public Health Sequence or the Advanced Biology Global and Public Health Sequence must complete the sequence with the following courses:

The Chicago series of foundational courses in Global and Public Health:

BIOS 25216Molecular Basis of Bacterial Disease100
or BIOS 25287 Introduction to Virology
HLTH 17000Introduction to Health and Society100

OR

The Paris series of foundational courses in Global and Public Health (offered during Winter Quarter):

BIOS 27815Infectious Diseases100
BIOS 29814Biological and Social Determinants of Health100

Physical and Mathematical Sciences Requirement

Students pursuing the major in the Global and Public Health Track will complete the following:

CHEM 11300Comprehensive General Chemistry III100
One of the following quantitative courses:
BIOS 26210Mathematical Methods for Biological Sciences I100
PHYS 12300General Physics III (or higher)100
STAT 22000Statistical Methods and Applications (or higher)100

NOTE 1: The third quarter of Calculus is NOT required for the Global and Public Health Track. Students MUST take BIOS 20151 Introduction to Quantitative Modeling in Biology (Basic) or BIOS 20152 Introduction to Quantitative Modeling in Biology (Advanced), and students in the Advanced Biology sequence MUST take BIOS 20236 Biological Dynamics. NO Mathematics courses may be substituted for these requirements.

NOTE 2: Students planning to apply to medical school should be aware of individual medical school admissions requirements and should tailor their program accordingly with the help of UChicago Careers in Healthcare

Upper-Level Elective Requirements

Students completing the major in the Global and Public Health Track must take eight upper-level electives distributed as follows: Four upper-level BIOS courses (BIOS 21000 to 28999) and four courses from the approved non-BIOS course list (see list below). Two of the BIOS electives must be in the area of global and public health (notated with a GP after the course title in the catalog).

Students who have completed the Advanced Biology Global and Public Health sequence must take three BIOS upper-level electives, two of which must be in the area of global and public health (notated with a GP after the course title in the catalog).

Note: Students in this track can use BIOS 20200 Introduction to Biochemistry as one of the BIOS upper-level electives and CHEM 22000 Organic Chemistry I as one of the non-BIOS upper-level electives.

Non-BIOS upper-level electives:

ANTH 21420Ethnographic Methods100
ANTH 24302Disability in Local and Global Contexts100
ANTH 24315Culture, Mental Health, and Psychiatry100
ANTH 24330Medical Anthropology100
BPRO 22800Drinking Alcohol: Social Problem or Normal Cultural Practice?100
BUSN 42300Global Health and Social Policy100
CCTS 21009Justice, Solidarity, and Global Health100
CHDV 21000Cultural Psychology100
CHEM 22000Organic Chemistry I100
ENST 25460Environmental Effects on Human Health100
GLST 23101Global Studies I100
HMRT 21400Health and Human Rights100
HLTH 27450Social Inequalities in Health: Race/Ethnicity & Class100
PBPL 21501Environmental Justice100
PBPL 25832Early Human Capital Development100
PBHS 22710Environmental Health100
PBHS 23700Sexual Health: Identity, Behavior, and Outcomes100
PBHS 31831Genetic & Molecular Epidemiology100
PBPL 25832Early Human Capital Development100
PBPL 26690The Politics of Health Care100
PBPL 27000International Economics100
PBPL 27905Global Health Metrics100
PHIL 21609Topics in Medical Ethics100
PSYC 25750The Psychology and Neurobiology of Stress100
PSYC 28791Behavioral Science and Public Policy100
RLST 24103Bioethics100
SSAD 21300Global Mental Health100

Additional Requirements: One quarter of independent field or research work in the area of Global and Public Health (approval of the Track Director Kathleen Beavis is required kbeavis@bsd.uchicago.edu).

Research opportunities of particular interest to students in this track can be found on the Interdisciplinary Biology Track Global and Public Health page.

Summary of Requirements: Global and Public Health Track

CHEM 11300Comprehensive General Chemistry III100
One of the following quantitative courses:100
Statistical Methods and Applications (or higher)
Mathematical Methods for Biological Sciences I
General Physics III (or above)
Global and Public Health Fundamentals Sequence or Advanced Biology Global and Public Health Fundamentals Sequence600
Four upper-level electives in Biological Sciences, BIOS 21000-28999 (at least two annotated GP) + 400
Four upper-level non-BIOS electives in Global and Public Health400
One quarter of approved research
Total Units1600

Honors for the Global and Public Health Track

Students wishing to complete an honors thesis should see Honors. When appropriate for their research topic and methods, students in this track may instead enroll in SOCI 29998 Sociology BA Thesis Seminar with approval. 

For questions about this track, please contact Global and Public Health Track Director Kathleen Beavis (kbeavis@bsd.uchicago.edu) or the Senior Biology Advisors

Computational Biology Track

Fundamentals Sequence Requirement

Students completing the Biological Sciences major in the Computational Biology Track must choose one of the following Fundamentals sequences:

1. Fundamentals of Computational Biology sequence—begins in the Winter Quarter of the first year and is structured to provide students with a foundation for interdisciplinary study in this field. Note that BIOS 20151 Introduction to Quantitative Modeling in Biology/BIOS 20152 Introduction to Quantitative Modeling in Biology (Advanced) and BIOS 20153 Fundamentals of Ecology and Evolutionary Biology fulfill the general education requirement in the biological sciences and are not counted towards the major.

BIOS 20151Introduction to Quantitative Modeling in Biology *# 100
or BIOS 20152 Introduction to Quantitative Modeling in Biology (Advanced)
BIOS 20153Fundamentals of Ecology and Evolutionary Biology *# 100
BIOS 20186Fundamentals of Cell and Molecular Biology100
BIOS 20187Fundamentals of Genetics100
BIOS 26210Mathematical Methods for Biological Sciences I100

OR

2. Advanced Computational Biology Fundamentals sequence—begins in the Autumn Quarter of the first year and requires a high level of preparedness in biology as well as a deep interest in research. The sequence is open to students who have achieved a score of 4 or 5 on the AP Biology test or by consent.* Students seeking consent should contact Michael Glotzer (mglotzer@uchicago.edu).

BIOS 20234Molecular Biology of the Cell100
BIOS 20235Biological Systems100
BIOS 20236Biological Dynamics100
BIOS 26210Mathematical Methods for Biological Sciences I100

In addition, students following either the Fundamentals of Computational Biology Sequence or the Advanced Computational Biology Sequence must complete the sequence with the following courses in computer programming:

Two courses in computer programming:

DATA 11800
  &  11900
Introduction to Data Science I
   and Introduction to Data Science II
200
OR
CMSC 14100
  &  14200
Introduction to Computer Science I
   and Introduction to Computer Science II
200
OR
CMSC 14200
  &  14300
Introduction to Computer Science II
   and Systems Programming I
200
OR
CMSC 14300
  &  14400
Systems Programming I
   and Systems Programming II +
200

AND

One course in Computational Approaches to Biological Problems†:

BIOS 26211Mathematical Methods for Biological Sciences II100
BIOS 26318Fundamentals of Biological Data Analysis100
BIOS 26120An Introduction to Bioinformatics and Proteomics100
BIOS 26121Introduction to Transcriptomics100
BIOS 26403Quantitative Immunobiology100
BIOS 26404Quantitative Genetics for the 21st Century100

Physical Sciences Requirements

CHEM 11300Comprehensive General Chemistry III (or higher)100
AND
CHEM 22000
  &  22100
Organic Chemistry I
   and Organic Chemistry II (or higher)
200
or PHYS 12100
PHYS 12200
General Physics I
and General Physics II
AND
STAT 22000Statistical Methods and Applications100
AND
STAT 24300Numerical Linear Algebra100
or MATH 19620 Linear Algebra

 Upper-Level Elective Requirements

Students completing the major in the Computational Biology Track must take five upper-level electives distributed as follows: Three upper-level BIOS courses in the area of computational biology (annotated CB) and two courses from the approved non-BIOS course list (see list below).

Students who have completed the Advanced Computational Biology Fundamentals sequence must take two BIOS upper-level courses in the area of computational biology (annotated CB).

Non-BIOS Electives:
CMSC 14300Systems Programming I (if not used to fulfill programming requirement)100
CMSC 14400Systems Programming II (if not used to fulfill programming requirement)100
CMSC 21800Data Science for Computer Scientists100
CMSC 23900Data Visualization ***100
CMSC 25025Machine Learning and Large-Scale Data Analysis100
CMSC 25300/STAT 27700Mathematical Foundations of Machine Learning **100
CMSC 25400/STAT 27725Machine Learning **100
CMSC 25440Machine Learning in Medicine **100
DATA 22100Introduction to Machine Learning: Concepts and Applications **100
DATA 27100-27200Data Science Clinic I-II (also fulfills research requirement)200
DATA 22700Data Visualization and Communication ***100
STAT 22810Epidemiology and Population Health100
MENG 21400Molecular Engineering Thermodynamics100

Other courses from quantitative programs may be counted by consent of the Track Director Anindita Basu (onibasu@uchicago.edu) and Dmitry Kondrashov (dkon@uchicago.edu).

Additional Requirements: One quarter of independent field or research work in the area of Computational Biology is required. This requirement can be fulfilled by approved independent research with a faculty mentor or by completion of DATA 27100 Data Science Clinic I or DATA 27200 Data Science Clinic II. More information on track-specific opportunities can be found on the Interdisciplinary Biology Computational Biology page. For approval of independent research, contact Track Directors Dmitry Kondrashov (dkon@uchicago.edu) and Anindita Basu (onibasu@uchicago.edu). 

Summary of Requirements: Computational Biology Track

CHEM 11300Comprehensive General Chemistry III (or higher)100
CHEM 22000
  &  22100
Organic Chemistry I
   and Organic Chemistry II (or higher)
200
or PHYS 12100
PHYS 12200
General Physics I
and General Physics II
STAT 22000Statistical Methods and Applications100
STAT 24300Numerical Linear Algebra100
or MATH 19620 Linear Algebra
Computational Biology Fundamentals Sequence or Advanced Computational Biology Fundamentals Sequence +300
Two courses in computer programming200
One course in Computational Applications to Biological Problems100
Three upper-level (BIOS 21000-28999) electives (annotated CB) +300
Two upper-level non-BIOS electives from the approved list200
One quarter of approved research
Total Units1600

For questions about this track, please contact the Track Directors Dmitry Kondrashov (dkon@uchicago.edu) and Anindita Basu (onibasu@uchicago.edu) or the Biology Advisors

Program Requirements for the Bachelor of Science in Biological Sciences

Students can earn a Bachelor of Science (BS) degree in Biological Sciences in any of the tracks by:

(1) completing three upper-level elective courses in Biological Sciences beyond those required for the BA degree, including BIOS 28900 Undergraduate Bachelor of Science Research (or both quarters of BIOS 00296 Undergraduate Honors Research if also pursuing Biology Research Honors)

AND

(2) writing a BS thesis under the supervision of an adviser who is a member of the Biological Sciences Division research faculty. The topic of the BS thesis must be appropriate for the track chosen. 

Students completing the honors program or a specialization in the Biology Track that requires a senior thesis can submit the same thesis for the BS degree. Candidates must declare their intent by submitting a faculty consent form no later than the end of the Spring Quarter of their third year in the College. Details of the BS degree and a timeline for completion of requirements are provided on the BSCD website, bscd.uchicago.edu.

Honors

Honors in Biological Sciences can be earned via one of two ways.

Research Honors: Emphasizes exceptional achievement in a program of original research (minimum cumulative GPA of 3.30 or above), plus submission and acceptance of an in-depth research thesis.

Scholar Honors: Recognizes exceptional academic performance (minimum cumulative GPA of 3.75 or above), including submission and acceptance of a scholarly thesis. 

Both programs require formal declarations of intent to seek honors by the candidates. The details of each program are provided on the BSCD website. Candidates must apply for either program no later than the beginning of Spring Quarter of their third year in the College. 

Research Opportunities

Students in all tracks are encouraged to carry out individual guided research in an area of their interest. A student may propose an arrangement with any faculty member in the Biological Sciences Division to sponsor and supervise research. Students may register for BIOS 00199 Undergraduate Research or BIOS 00299 Advanced Research: Biological Sciences at any time if they want to receive course credit for their research work, but this is not required. (Please note that there are required research courses for the BS and Research Honors programs.) For more information, see bscd.uchicago.edu/content/undergrad-research or contact Paul Strieleman (pstriele@uchicago.edu). NOTE: Course credit cannot be given for work that is compensated by a salary. BIOS 00199 and BIOS 00299 may not be used to meet the requirements of the Biological Sciences degree.

Students interested in research are also encouraged to work in a research lab over the summer. In addition to individual arrangements with faculty, students may take advantage of fellowship programs. Application deadlines for fellowships range from mid-February to early April. Please see bscd.uchicago.edu/content/undergrad-research for more information about fellowship opportunities and funding for research in the Biological Sciences at the University of Chicago, or the College Center for Research and Fellowships (ccrf.uchicago.edu), and Career Advancement for a searchable database of internal and external research and fellowship opportunities.

Prospective biology majors interested in learning more about the variety of labs conducting biological research on campus can attend one or more quarters of BIOS 10098 Pizza with the PIs: Introduction to Biology Research at The University of Chicago.

BIOS 10098. Pizza with the PIs: Introduction to Biology Research at The University of Chicago. 000 Units.

This is an optional, non-credit course for students interested in carrying out research at the University of Chicago. It provides students with an opportunity to get to know the research faculty, identify potential labs to join, and be inspired by the research advances happening on our campus. Each week, a different faculty member from any of the various departments in the Biological Sciences Division (BSD) will present their own research work in a 50 minute, lunch-time seminar. Registration for the course is required to be able to attend these seminars. Pizza will be served.

Instructor(s): N. Bhasin     Terms Offered: Spring Winter
Prerequisite(s): This course is for prospective biology majors only. Students should have attended, or be enrolled in, at least one quarter of any Fundamentals sequence in biology.
Note(s): This course is non-credit. Students will get a grade of P/F based on attendance at 7 out of 9 weekly seminars. This course can be taken along-with 4 other regular courses and the grade of P/F from this course will not affect student GPA. This course does not confer any credit towards the biology major, biology minor, or general education requirement in biology.

Minor in Biological Sciences

Students who wish to complete a Minor in Biological Sciences should meet with one of the BSCD Senior Advisers, Chris Andrews (candrews@uchicago.edu) or Megan McNulty (mmcnulty@uchicago.edu), by the Spring Quarter of their second year in order to obtain formal consent and to plan out the appropriate program of study.

A student may earn a Minor in Biological Sciences with the following coursework:

General Education Requirement in the Biological Sciences

Two quarters of one of the following sequences:

Fundamentals in Biological Sciences Sequence

BIOS 20153Fundamentals of Ecology and Evolutionary Biology100
BIOS 20151Introduction to Quantitative Modeling in Biology100
or BIOS 20152 Introduction to Quantitative Modeling in Biology (Advanced)

Health Professions Preparation Sequence

BIOS 20170Microbial and Human Cell Biology100
BIOS 20171Human Genetics and Developmental Biology100

 General Education Sequence for Non-Majors

BIOS 10130Principles of Biology100
or BIOS 10140 Inquiry-based Exploration of Biology
& one biology topics course (BIOS 11000-19999) #100

Note: It is recommended that students minoring in the Biological Sciences take BIOS 20153 and BIOS 20151 (or BIOS 20152) to fulfill their general education requirement, as these offer the best preparation for the fundamentals sequence courses and the upper-level electives. However, any of the courses above will be accepted. 

General Education Requirement in the Physical Sciences

MATH 13100-13200Elementary Functions and Calculus I-II (or higher)200

Fundamentals Sequence Requirement

Three courses from the Fundamentals in Biological Sciences Sequence:

BIOS 20186Fundamentals of Cell and Molecular Biology *100
BIOS 20187Fundamentals of Genetics100
and one of the following:
BIOS 20188Fundamentals of Physiology100
BIOS 20189Fundamentals of Developmental Biology100
BIOS 20196Ecology and Conservation100
BIOS 20198Biodiversity100

OR

Three courses from the Health Professions Preparation Sequence:

BIOS 20172Mathematical Modeling for Pre-Med Students100
BIOS 20173Perspectives of Human Physiology100
BIOS 20175Biochemistry and Metabolism100

Upper-Level Electives Requirement

Four upper-level electives (BIOS 21000-28999).

No course in the minor can be double counted with the student's major(s) or with other minors, nor can they be counted toward general education requirements. More than half of the requirements for the minor must be met by registering for courses with University of Chicago course numbers.  All courses for the minor must be taken for quality grades.

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Grading and Academic Honesty

Students must receive quality grades in all courses that fulfill requirements for the BA or BS degree in Biological Sciences.

Academic dishonesty is a matter of grave concern to the faculty of the Biological Sciences Collegiate Division and will not be tolerated. Students should become familiar with the guidelines presented in Doing Honest Work in College by Charles Lipson and consult with each of their instructors to make sure they understand the specific expectations of each course. Consequences of academic dishonesty (including plagiarism) may include suspension or expulsion from the University.

Biological Sciences (BIOS) Courses

Students must confirm their registration with their instructors by the second class meeting or their registration may be canceled.

In the following course descriptions:

L indicates courses with a laboratory.

E indicates a course that can be counted towards a degree in Biological Sciences through the Ecology and Evolution Track.

GP indicates a course that can be counted towards a degree in Biological Sciences through the Global and Public Health Track.

CB indicates a course that can be counted towards a degree in Biological Sciences through the Computational Biology Track. 

Health Professions Preparation Sequence for Non-Majors

This sequence (BIOS 20170- BIOS 20175) is an integrated set of biology courses designed to prepare non-biological sciences majors for application to medical school. This sequence cannot substitute for the Fundamentals Sequence in any of the tracks in the Biological Sciences major but can be used to fulfill requirements in the Biological Sciences Minor. However, completion of the Health Professions Preparation Sequence qualifies a student to take upper-level BIOS elective courses. 

BIOS 20170. Microbial and Human Cell Biology. 100 Units.

This course is the entry point into an integrated biology sequence designed to prepare non-biology majors for application to schools in the health professions. We explore topics in human cell biology within the context of evolutionary biology, chemistry, microbiology, and medicine. We pay special attention to the influence of prokaryotes on the history of life and to the ecological interactions between humans and their microbiota, which have major implications for human health and disease. Students read and discuss papers from the scientific literature, attend discussions and gain experience with microbiological basic microscopy techniques in lab.

Instructor(s): C. Andrews, R. Bednarczyk     Terms Offered: Winter. L.
Prerequisite(s): This sequence is open only to students who are not planning to major in Biological Sciences or Biological Chemistry and cannot be applied to either of these majors. It is recommended that students start the sequence in their first or second year.

BIOS 20171. Human Genetics and Developmental Biology. 100 Units.

This course covers the fundamentals of genetics, with an emphasis on human traits and diseases. Topics include Mendelian genetics, simple and complex traits, genetic diseases, the human genome, and testing for human traits and diseases. After establishing a foundation in genetics, we will discuss mechanisms underlying differentiation and development in humans. We will focus on events that lead to gastrulation and the establishment of the body plan (how humans develop from an un-patterned egg into a recognizable human form). Other topics may include limb development and stem cell biology.

Instructor(s): O. Pineda-Catalan, Staff.     Terms Offered: Spring. L.
Prerequisite(s): BIOS 20170; must be taken concurrently with BIOS 20172.

BIOS 20172. Mathematical Modeling for Pre-Med Students. 100 Units.

This course covers mathematical approaches in biology and medicine, including basic statistics and hypothesis testing, mathematical modeling of biological systems, and an introduction to bioinformatics. Students will apply what they learn as they analyze data and interpret primary papers in the biological and clinical literature. BIOS 20172 lays the foundation for biomathematical approaches explored during subsequent courses in the BIOS 20170s sequence.

Instructor(s): E. Haddadian     Terms Offered: Spring. L.
Prerequisite(s): BIOS 20170, concurrent enrollment in BIOS 20171

BIOS 20173. Perspectives of Human Physiology. 100 Units.

This course will explore the structure and function of the human body as a set of integrated, interdependent systems. We will continue the cellular, genetic, and developmental themes of the previous courses to explore the emergent functions of the human body, from cells to systems. The laboratory exercises will allow the students to experience the concepts discussed in lecture in a way that introduces them to the methods of academic research, including the application of mathematical models to physiological questions. Students will be asked to serve as test subjects in several of the laboratory exercises. Required weekly discussions include student presentations on papers from the scientific literature.

Instructor(s): C. Andrews, M. Osadjan.     Terms Offered: Autumn. L.
Prerequisite(s): BIOS 20170, BIOS 20171, BIOS 20172

BIOS 20175. Biochemistry and Metabolism. 100 Units.

The course introduces cellular biochemical metabolism. The chemical characteristics, biochemical properties, and function of carbohydrates, proteins, and lipids are introduced. Basic protein structure and enzyme kinetics including basic allosteric interactions are considered. The integration of carbohydrates, proteins, and lipids in cellular intermediary metabolism is examined including pathway regulation and bioenergetics. Adaptation of the pathways to changes in nutritional or disease state is used to highlight interrelationships in cellular metabolism.

Instructor(s): P. Strieleman     Terms Offered: Winter
Prerequisite(s): BIOS 20170, BIOS 20171, BIOS 20172, BIOS 20173

Fundamentals Sequence Courses for Biological Sciences Majors

Students registering for Fundamentals Sequence courses in the Biological Sciences major must have completed or placed out of general or honors chemistry or be enrolled concurrently in general or honors chemistry.

BIOS 20151. Introduction to Quantitative Modeling in Biology. 100 Units.

The goal for this course is to give future biologists the quantitative tools to fully participate in modern biological research. These include descriptive statistics, linear regression, stochastic independence and hypothesis testing, Markov models and stationary probability distributions, solutions of linear differential equations, equilibria and stability analysis of nonlinear differential equations. The ideas are applied to different areas of biology, e.g. molecular evolution, allometry, epidemiology, and biochemistry, and implemented by students in computer assignments using the R computational platform.

Instructor(s): Section 1: D. Kondrashov; Section 2: A. Basu     Terms Offered: Spring. L.
Prerequisite(s): Two quarters of calculus of any sequence (MATH 13200 or 15200 or 16200). First-year Biology Major standing only.
Note(s): This course is required to partially fulfill the general education requirement in biology for Biological Sciences majors in all tracks, except for students taking BIOS 20152 and students in the Advanced Biology sequence. This course cannot be used as a Topics course for the general education requirement for non-Biological Sciences majors.

BIOS 20152. Introduction to Quantitative Modeling in Biology (Advanced) 100 Units.

This is a more advanced version of 20151, intended for students with greater mathematical maturity. In addition to the topics covered in the regular version, students will learn about nonlinear least-squares fitting, eigenvalues and eigenvectors, bifurcations and bistability in differential equations. Additional applications will include phylogenetic distance and systems biology.

Instructor(s): D. Kondrashov     Terms Offered: Winter. L.
Prerequisite(s): MATH placement of 15200 or higher OR either MATH 15200 or MATH 16200 and second-year standing or higher.
Note(s): This course can replace BIOS 20151 to partially fulfill the general education requirement in biology for Biological Sciences majors in all tracks. This course cannot be used as a Topics course for the general education requirement for non-Biological Sciences majors.

BIOS 20153. Fundamentals of Ecology and Evolutionary Biology. 100 Units.

This course surveys the basic principles of ecology and evolutionary biology to lay the foundation for further study in all fields of biology. Broad ecological concepts, such as population growth, disease dynamics, and species interactions, will be explored through a combination of published data, simulations, and mathematical models. The emphasis is placed on "ecological thinking". Essential topics in the modern study of evolutionary biology will be covered with a focus on both theory and empirical examples. Examples of topics include history of evolutionary thought, evidence for evolution, mechanisms of microevolution, phylogenetics, molecular evolution, and speciation.

Instructor(s): M. Kronforst, C. Brook, C. Andrews, A. Hunter.      Terms Offered: Winter. L.
Note(s): This course is required to partially fulfill the general education requirement in biology for Biological Sciences majors in all tracks, except for students taking the Advanced Biology sequence.

BIOS 20186. Fundamentals of Cell and Molecular Biology. 100 Units.

This course is an introduction to molecular and cellular biology that emphasizes the unity of cellular processes amongst all living organisms. Topics are the structure, function, and synthesis of nucleic acids and protein; structure and function of cell organelles and extracellular matrices; energetics; cell cycle; cells in tissues and cell-signaling; temporal organization and regulation of metabolism; regulation of gene expression; and altered cell functions in disease states.

Instructor(s): Section 1: B. Glick, D. Kovar, C. Schonbaum; Section 2: R. Fehon, D. Pincus, P. Smith     Terms Offered: Spring. L.
Prerequisite(s): BIOS 20153 & at least concurrent registration in 20151 or 20152 or similar math prep. Avg. grade of C or higher in, and completion of, CHEM 10100-10200 or 11100-11200 or 12100-12200, a 5 on the AP Chem. exam, or consent. Reg. by lab sec.
Note(s): NSCI majors and other students may take BIO20186 without BIOS 20151/20152, 20153 unless they plan to pursue a double major in Biological Sciences. All students in BIOS 20186 will be expected to possess the competency in mathematical modeling of biological phenomena covered concurrently in BIOS 20151 or BIOS 20152.

BIOS 10086. Collaborative Learning in Biology- Cell & Molecular Biology. 000 Units.

Optional, limited enrollment workshop for students concurrently enrolled in BIOS 20186 Fundamentals of Cell and Molecular Biology. An instructional professor will guide small groups of students in weekly workshops. Students will analyze problem sets designed to complement, but not duplicate, assignments and material in Cell and Molecular Biology. Students will work collaboratively in small groups on assigned problems, with reference to course materials such as lecture notes and assigned texts. These workshops are also designed to develop communication skills and teamwork. Collaborative learning requires being present and engaged, so this zero-credit course is graded P/F based on student's participation and attendance.

Instructor(s): T. Sosa     Terms Offered: Spring
Prerequisite(s): Concurrent enrollment in BIOS 20186.

BIOS 20187. Fundamentals of Genetics. 100 Units.

The goal of this course is to integrate recent developments in molecular genetics into the structure of classical genetics with an emphasis on recent advances in genetics and genomics. Topics include Mendelian inheritance, genotype-phenotype relationships, linkage analysis, modern gene mapping techniques, gene expression, model systems genetics and analysis of genetic pathways.

Instructor(s): Section 1: D. Missiakis, K. Butler, A. Brock. Section 2: J. Malamy, H-C. Lee, C. Schonbaum.     Terms Offered: Autumn. L.
Prerequisite(s): BIOS 20186

BIOS 10087. Collaborative Learning in Biology- Genetics. 000 Units.

Optional, limited enrollment workshop for students concurrently enrolled in BIOS 20187. An instructional professor will guide small groups of students in weekly workshops. Students will analyze problem sets designed to complement, but not duplicate, assignments and material in Genetics. Students will work collaboratively in small groups on assigned problems, with reference to course materials such as lecture notes and assigned texts. These workshops are also designed to develop communication skills and teamwork. Collaborative learning requires being present and engaged, so this zero-credit course is graded P/F based on student's participation and attendance.

Instructor(s): T. Sosa     Terms Offered: Autumn
Prerequisite(s): Concurrent enrollment in BIOS 20187.

BIOS 20188. Fundamentals of Physiology. 100 Units.

This course focuses on the physiological problems that animals (including humans) face in natural environments; solutions to these problems that the genome encodes; and the emergent physiological properties of the molecular, cellular, tissue, organ, and organismal levels of organization. Lectures and labs emphasize physiological reasoning, problem solving, and current research.

Instructor(s): Winter: M. Osadjan; Spring: D. McGehee, M. Osadjan     Terms Offered: Spring Winter. L.
Prerequisite(s): BIOS 20187 or BIOS 20235

BIOS 10088. Collaborative Learning in Biology- Physiology. 000 Units.

Optional, limited enrollment workshop for students concurrently enrolled in BIOS 20188. An instructional professor will guide small groups of students in weekly workshops. Students will analyze problem sets designed to complement, but not duplicate, assignments and material in Physiology. Students will work collaboratively in small groups on assigned problems, with reference to course materials such as lecture notes and assigned texts. These workshops are also designed to develop communication skills and teamwork. Collaborative learning requires being present and engaged, so this zero-credit course is graded P/F based on student's participation and attendance.

Instructor(s): T. Sosa     Terms Offered: Winter
Prerequisite(s): Concurrent enrollment in BIOS 20188.

BIOS 20189. Fundamentals of Developmental Biology. 100 Units.

This course covers both the classical experiments that contributed to our understanding of developmental biology and the recent explosion of information about development made possible by a combination of genetic and molecular approaches. Examples from both vertebrate and invertebrate systems are used to illustrate underlying principles of animal development.

Instructor(s): Winter: R. Ho, S. Horne-Badovinac, C. Schonbaum. Spring: W. Du, A. Imamoto, A. Brock.     Terms Offered: Spring Winter. L.
Prerequisite(s): BIOS 20187.

BIOS 20200. Introduction to Biochemistry. 100 Units.

This course meets the biochemistry requirement in the Biological Sciences major. This course examines the chemical nature of cellular components, enzymes, and mechanisms of enzyme activity, energy interconversion, and biosynthetic reactions. Strong emphasis is given to control and regulation of metabolism through macromolecular interactions.

Instructor(s): M. Makinen, P. Strieleman, M. Zhao. L.     Terms Offered: Autumn Spring. L.
Prerequisite(s): Completion of a Biological Sciences Fundamentals Sequence with an average grade of C and CHEM 22000-22100/23100 with an average grade of C.
Note(s): GP.

BIOS 20196. Ecology and Conservation. 100 Units.

This course focuses on the contribution of ecological theory to the understanding of current issues in conservation biology. We emphasize quantitative methods and their use for applied problems in ecology (e.g., risk of extinction, impact of harvesting, role of species interaction, analysis of global change). Course material is drawn mostly from current primary literature; lab and field components complement concepts taught through lecture. Prerequisite(s): BIOS 20150, BIOS 20151 or BIOS 20152 Note(s): BIOS 20196 is identical to the previously offered BIOS 23251. Students who have taken BIOS 23251 should not enroll in BIOS 20196. Equivalent Course(s): ENSC 24400

Instructor(s): C. Pfister, E. Larsen     Terms Offered: Autumn. L.
Prerequisite(s): BIOS 20151 or BIOS 20152
Note(s): BIOS 20196 is identical to the previously offered BIOS 23251. Students who have taken BIOS 23251 should not enroll in BIOS 20196.
Equivalent Course(s): ENSC 24400

BIOS 20198. Biodiversity. 100 Units.

Section 1. Students will review the three biodiversity levels, i.e., genetic, species, and ecosystem, using a systemic approach to appraise the complex network of interactions among living organisms on our planet. During the course, students will survey the main taxonomic groups, such as archaea, bacteria, single-celled eukaryotes, fungi, plants, and animals, to identify their defining characteristics, describe their evolutionary origin, and evaluate their role in ecosystems. Students will integrate knowledge and analytical tools to assess the biodiversity in their neighborhoods, as well as differentiate parameters that impact distribution and abundance of organisms in their local ecosystems. Section 2. This course presents an overview of the diversity of living organisms, including archaea, bacteria, single-celled eukaryotes, fungi, plants, and animals, with an emphasis on their evolutionary histories, relationships, and the biological and evolutionary implications of the characteristic features of each group. We will explore how these different lineages have evolved remarkable solutions to challenges in locomotion, metabolism, and life in extreme environments. Work in the lab will take advantage of the diversity of organisms that live around, or are maintained at, the Marine Biological Laboratory at Woods Hole, MA.

Instructor(s): Section 1: O. Pineda, C. Andrews; Section 2: A. Gillis, O. Pineda     Terms Offered: Spring. L. Section 1 will be taught on the Chicago campus. Section 2 will be taught during Spring Quarter at MBL in Woods Hole, MA (https://college.uchicago.edu/academics/mbl-spring-quarter-biology)
Prerequisite(s): PQ: BIOS 20153 for Biological Sciences majors; not required for GeoSci majors or students taking BIOS 20198 as part of a general education sequence
Equivalent Course(s): CEGU 20198

Advanced Biology Fundamentals Sequence 

This is an accelerated four-quarter Fundamentals sequence (BIOS 20234-20236 and BIOS 20188) designed for motivated first-year students with exceptionally strong science and mathematics backgrounds and an intense interest in research in the biological sciences. A score of 4 or 5 on the AP Biology test or consent is required; students seeking consent should contact Michael Glotzer (mglotzer@uchicago.edu). Successful students usually also have strong preparation in biology, chemistry, and calculus as well as some experience in computer programming. Students are expected to devote significant time to this sequence (minimum four to eight hours/week for reading primary literature and background information and for working problem sets, in addition to attendance at lectures and participation in laboratory exercises and discussion sections). Upon completion of the first three quarters of the Advanced Biology sequence, students will have three credits towards the Biological Sciences major and they will have met the general education requirement in the biological sciences. 

Note: Biological Sciences majors who opt not to complete the sequence after the first quarter (BIOS 20234 Molecular Biology of the Cell) should take BIOS 20151/BIOS 20152, which will be applied to their general education requirement in the Biological Sciences along with their AP Biology credit. BIOS 20234 would be counted as a credit towards the Biological Sciences major. Students would then complete the major by following the requirements for either the Biology Track or an Interdisciplinary Biology Track. 

Note: Students who complete the Advanced Biology sequence but do not have a score of 4 or 5 on the AP Biology exam will need to take one additional course to fulfill the general education requirement in the Biological Sciences. Students should consult with BSCD Senior Advisers (Megan McNulty, mmcnulty@uchicago.edu, and Chris Andrews, candrews@uchicago.edu) to select an appropriate course.

BIOS 20234. Molecular Biology of the Cell. 100 Units.

This course covers the fundamentals of molecular and cellular biology. Topics include protein structure and function; DNA replication, repair, and recombination; transcription, translation, control of gene expression; cytoskeletal dynamics; protein modification and stability; cellular signaling; cell cycle control; mitosis; and meiosis.

Instructor(s): M. Glotzer, A. Ruthenburg, N. Bhasin. L.     Terms Offered: Autumn
Prerequisite(s): Score of 4 or 5 on the AP biology test or consent.
Note(s): To continue in the sequence, students must receive a minimum grade of B- in BIOS 20234

BIOS 20235. Biological Systems. 100 Units.

Students preparing for the health professions must take BIOS 20235 and 20188 in sequence. This course builds upon molecular cell biology foundations to explore how biological systems function. Topics include classical and molecular genetics, developmental signaling networks, genomics, proteomics, transcriptomics, and biological networks.

Instructor(s): I. Rebay, M, Pascual, N. Bhasin. L.     Terms Offered: Winter
Prerequisite(s): A grade of B- or above in BIOS 20234

BIOS 20236. Biological Dynamics. 100 Units.

This class introduces the use of quantitative approaches to study biological dynamics. Deeper exploration of cellular and developmental processes introduced in BIOS 20234 and BIOS 20235 will emphasize the use of quantitative analysis and mathematical modeling to infer biological mechanisms from molecular interactions. The lab portion of the class will introduce basic approaches for simulating biological dynamics using examples drawn from the lectures.

Instructor(s): E. Munro, M. Rust.     Terms Offered: Spring. L.
Prerequisite(s): BIOS 20234 and BIOS 20235 with a minimum grade of B- in each course.

BIOS 20188. Fundamentals of Physiology. 100 Units.

This course focuses on the physiological problems that animals (including humans) face in natural environments; solutions to these problems that the genome encodes; and the emergent physiological properties of the molecular, cellular, tissue, organ, and organismal levels of organization. Lectures and labs emphasize physiological reasoning, problem solving, and current research.

Instructor(s): Winter: M. Osadjan; Spring: D. McGehee, M. Osadjan     Terms Offered: Spring Winter. L.
Prerequisite(s): BIOS 20187 or BIOS 20235

Upper-level Elective Courses

Course numbers 21000-28999 

These courses assume mastery of the material covered in the Fundamentals Sequences and explore specific areas of biology at an advanced level. In most cases, students will be reading primary scientific literature. Students who have not yet completed the Fundamentals Sequence should consult with the course instructor and the BSCD Senior Advisers before registering for an upper-level elective course. Students must confirm their registration with their instructors by the second class meeting or their registration may be canceled.

BIOS 21216. Introduction to Statistical Genetics. 100 Units.

In this course, we will cover the core concepts and statistical procedures that are used in the mapping of genetic traits from observational data. We will cover statistical techniques used in genome-wide association studies and tools for "post-GWAS" analysis. Proficiency in R programming and the command line needs to be achieved early on to keep up with the course's demanding homework problems.

Instructor(s): Xin He, Hae Kyung Im     Terms Offered: Winter
Prerequisite(s): For Biological Sciences majors: Three quarters of a Biological Sciences Fundamentals sequence
Note(s): E. GP. CB.
Equivalent Course(s): HGEN 47100

BIOS 21236. Genetics of Model Organisms. 100 Units.

A small number of organisms have been chosen for extensive study by biologists. The popularity of these organisms derives largely from the fact that their genomes can be easily manipulated, allowing sophisticated characterization of biological function. This course covers modern methods for genetic analysis in budding yeast (Saccharomyces cerevisiae), fruit flies (Drosophila melanogaster), plants (Arabidopsis thaliana), and mice (Mus musculus). Case studies demonstrate how particular strengths of each system have been exploited to understand such processes as genetic recombination, pattern formation, and epigenetic regulation of gene expression.

Instructor(s): D. Bishop, H-C. Lee, E. Ferguson, X. Zhang.     Terms Offered: Autumn
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals sequence including BIOS 20187 or BIOS 20235
Note(s): E.

BIOS 21237. Developmental Mechanisms. 100 Units.

This course provides an overview of the fundamental questions of developmental biology, with particular emphasis on the genetic, molecular and cell biological experiments that have been employed to reach mechanistic answers to these questions. Topics covered will include formation of the primary body axes, the role of local signaling interactions in regulating cell fate and proliferation, the cellular basis of morphogenesis, and stem cells.

Instructor(s): E. Ferguson, R. Fehon     Terms Offered: Winter
Prerequisite(s): For undergraduates only: Three quarters of a Biological Sciences Fundamentals Sequence including BIOS 20189, or BIOS 20235. AND CONSENT OF INSTRUCTOR
Equivalent Course(s): DVBI 36400, MGCB 36400

BIOS 21238. Cell Biology II. 100 Units.

This course covers the mechanisms with which cells execute fundamental behaviors. Topics include signal transduction, cell cycle progression, cell growth, cell death, cancer biology, cytoskeletal polymers and motors, cell motility, cytoskeletal diseases, and cell polarity. Each lecture will conclude with a dissection of primary literature with input from the students. Students will write and present a short research proposal, providing excellent preparation for preliminary exams.

Instructor(s): M. Glotzer, D. Kovar     Terms Offered: Spring
Prerequisite(s): For undergraduates: Three quarters of a Biological Sciences Fundamentals Sequence.
Equivalent Course(s): MGCB 31700, DVBI 31700, BCMB 31700

BIOS 21306. Human Genetics and Evolution. 100 Units.

The goal of this course is to provide an evolutionary perspective on the molecular genetic bases of human diseases and non-clinical human traits. The course covers fundamental concepts and recent progress in Mendelian and complex trait mapping as well as evolutionary principles as they apply to genomics analyses of DNA sequence variation in human populations. These topics will be introduced through lectures and will be complemented by discussion and student presentations of original research papers.

Instructor(s): Y. Li and R. Blekhman     Terms Offered: Autumn
Prerequisite(s): Three quarters of a Biological Fundamentals Sequence including BIOS 20187 or BIOS 20235.
Note(s): E. GP.

BIOS 21317. Topics in Biological Chemistry. 100 Units.

Required of students who are majoring in biological chemistry. This course examines a variety of biological problems from a chemical and structural perspective, with an emphasis on molecular machines. Topics include macromolecular structure-function relationships, DNA synthesis and repair, RNA folding and function, protein synthesis, targeting and translocation, molecular motors, membrane proteins, photosynthesis, and mechanisms of signal transduction. Computer graphics exercises and in-class journal clubs complement the lecture topics.

Instructor(s): P. Rice, R. Keenan     Terms Offered: Spring
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals sequence and BIOS 20200.

BIOS 21328. Biophysics of Biomolecules. 100 Units.

This course covers the properties of proteins, RNA, and DNA, as well as their interactions. We emphasize the interplay between structure, thermodynamics, folding, and function at the molecular level. Topics include cooperativity, linked equilibrium, hydrogen exchange, electrostatics, diffusion, and binding.

Instructor(s): Sosnick, T.     Terms Offered: Spring
Equivalent Course(s): BCMB 32200, BPHS 31000

BIOS 21349. Protein Structure and Functions in Medicine. 100 Units.

This course explores how molecular machinery works in the context of medicine (vision, fight or flight, cancer, and action of drugs). We first explore the physical and biochemical properties of proteins in the context of cellular signaling. We then examine how proteins and other cellular components make up the signal transduction pathway of humans and conduct their biological functions. The course engages students to strengthen their scientific communication and teaching skills via the in-class podcast, oral examinations, computer-aided structural presentations, student lectures, and discussions.

Instructor(s): W-J. Tang     Terms Offered: Spring
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals sequence. Biochemistry strongly recommended.
Equivalent Course(s): CABI 31900, NURB 33500

BIOS 21356. Vertebrate Development. 100 Units.

This advanced-level course combines lectures, student presentations, and discussion sessions. It covers major topics on the developmental biology of embryos (e.g. formation of the germ line, gastrulation, segmentation, nervous system development, limb pattering, organogenesis). We make extensive use of the primary literature and emphasize experimental approaches including embryology, genetics, and molecular genetics.

Instructor(s): V. Prince, P. Kratsios.     Terms Offered: Winter
Prerequisite(s): For Biological Sciences majors: Three quarters of a Biological Sciences Fundamentals Sequence including BIOS 20189 or BIOS 20190
Equivalent Course(s): MGCB 35600, DVBI 35600, ORGB 33600

BIOS 21358. Simulation, Modeling, and Computation in Biophysics. 100 Units.

This course develops skills for modeling biomolecular systems. Fundamental knowledge covers basic statistical mechanics, free energy, and kinetic concepts. Tools include molecular dynamics and Monte Carlo simulations, random walk and diffusion equations, and methods to generate random Gaussian and Poisson distributors. A term project involves writing a small program that simulates a process. Familiarity with a programming language or Mathlab would be valuable.

Instructor(s): B. Roux     Terms Offered: Winter
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals sequence, BIOS 20200 and BIOS 26210-26211, or consent from instructor
Note(s): CB
Equivalent Course(s): CHEM 31358, CPNS 31358, BCMB 31358

BIOS 21360. Advanced Molecular Biology. 100 Units.

This course covers genome structures, transcription of DNA to RNA, messenger RNA splicing, translation of RNA to protein, transcriptional and post-transcriptional gene regulations, non-coding RNA functions, epigenetics and epi-transcriptomics. Basic methods in molecular biology will also be covered. The course also includes special, current topics on genomics, single molecule studies of gene expression, epi-transcriptomics, and others.

Instructor(s): J. Fei, T. Pan.     Terms Offered: Winter
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals Sequence including BIOS 20187 or BIOS 20235 and Organic Chemistry, or consent of instructor.

BIOS 21415. Stem Cells in Development and Diseases. 100 Units.

This course will provide a survey of concepts and biology of stem cells based on experimental evidence for their involvement in developmental processes and human diseases. Topics will discuss classic models as well as recent advance made in the biomedical research community.

Instructor(s): A. Imamoto, X. Wu     Terms Offered: Winter
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals Sequence, including BIOS 20186 and BIOS 20187

BIOS 21416. Stem Cells and Regeneration. 100 Units.

The course will focus on the basic biology of stem cells and regeneration, highlighting biomedically relevant findings that have the potential to translate to the clinic. We will cover embryonic and induced pluripotent stem cells, as well as adult stem cells from a variety of systems, both invertebrate and vertebrates.

Instructor(s): H. Marlow, E. Ferguson, V. Prince, J. Cunningham,      Terms Offered: Spring
Prerequisite(s): For undergraduates only: Three quarters of a Biological Sciences fundamentals Sequence
Equivalent Course(s): DVBI 36200

BIOS 21506. Biological Physics. 100 Units.

This course will focus on unifying problems and themes found across biology that benefit from a quantitative approach. Questions covered include: How do evolved non-equilibrium mechanisms get around the constraints of equilibrium thermodynamics? What are the minimal requirements for matter to become life by replicating and evolving? How do living systems partition limited resources (energy, matter) acquired from the environment? How do living systems exploit dynamical systems behaviors to store and retrieve memories of past environments on different timescales? No specialized biological knowledge assumed.

Terms Offered: Winter
Prerequisite(s): PHYS 13300 or PHYS 14300, or permission of Instructor.
Note(s): Students majoring in Physics may use this course either as a Physics elective OR as a upper level elective in the Biological Sciences major.
Equivalent Course(s): PHYS 25500

BIOS 21507. Stem Cell Biology, Regeneration, and Disease Modeling. 100 Units.

In this course, students will gain an understanding of the science and application of tissue engineering, a field that seeks to develop technologies for restoring lost function in diseased or damaged tissues and organs. The course will first introduce the underlying cellular and molecular components and processes relevant to tissue engineering: extracellular matrices, cell/matrix interactions such as adhesion and migration, growth factor biology, stem cell biology, inflammation, and innate immunity. The course will then discuss current approaches for engineering a variety of tissues, including bone and musculoskeletal tissues, vascular tissues, skin, nerve, and pancreas. Students will be assessed through in-class discussions, take-home assignments and exams, and an end-of-term project on a topic of the student's choice.

Instructor(s): Huanhuan Chen     Terms Offered: Winter
Prerequisite(s): BIOS 20186 or BIOS 20234
Note(s): CB
Equivalent Course(s): MPMM 34300, MENG 33110, MENG 23110

BIOS 21510. Chromatin & Epigenetics. 100 Units.

This course presents the dynamic nature of the physiological genome - an exquisitely regulated macromolecular polymer termed chromatin - that gives rise to hundreds of cellular identities, each adaptable to various environmental milieu. Students will explore the mechanisms and determinants that shape distinct chromatin conformations and their influences on gene expression and cell fate. Topics include histone modifications, ATP-dependent chromatin remodeling, DNA methylation, Polycomb, heterochromatin, topologically associating domains, phase transition, and non-coding RNA. Students will apply their knowledge to understand the role of chromatin structure in development (e.g. lineage specification), disease (e.g. cancer) and potential therapeutics (e.g. cellular reprogramming). Students will leave the course with an in-depth knowledge of cutting-edge epigenetic methodologies as well as the ability to critically evaluate primary literature and propose original scientific research.

Instructor(s): Koh, A.     Terms Offered: Spring
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals Sequence
Equivalent Course(s): IMMU 33000

BIOS 22233. Comparative Vertebrate Anatomy. 100 Units.

This course covers the structure and function of major anatomical systems of vertebrates. Lectures focus on vertebrate diversity, biomechanics, and behavior (from swimming and feeding to running, flying, seeing, and hearing). Labs involve detailed dissection of animals (muscles, organs, brains) and a focus on skull bones in a broad comparative context from fishes to frogs, turtles, alligators, mammals, birds, and humans. Field trip to Field Museum and visit to medical school lab for human dissection required.

Instructor(s): M. Westneat. L.      Terms Offered: Winter
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals Sequence.
Note(s): Offered Winter during odd years. E.
Equivalent Course(s): ORGB 32233

BIOS 22245. Biomechanics: How Life Works. 100 Units.

This course will explore form and function in a diversity of organisms, using the principles of physics and evolutionary theory to understand why living things are shaped as they are and behave in such a diversity of ways. Biomechanics is at the interface of biology, physics, art, and engineering. We will study the impact of size on biological systems, address the implications of solid and fluid mechanics for organismal design, learn fundamental principles of animal locomotion, and survey biomechanical approaches. Understanding the mechanics of biological organisms can help us gain insight into their behavior, ecology and evolution.

Instructor(s): M. Westneat     Terms Offered: Spring. L. Spring.
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals sequence. Physics useful.
Note(s): This course will include a lab and will alternate years with BIOS 22233. E.
Equivalent Course(s): EVOL 32245, ORGB 32245

BIOS 22250. Chordates: Evolution and Comparative Anatomy. 100 Units.

Chordate biology emphasizes the diversity and evolution of modern vertebrate life, drawing on a range of sources (from comparative anatomy and embryology to paleontology, biomechanics, and developmental genetics). Much of the work is lab-based, with ample opportunity to gain firsthand experience of the repeated themes of vertebrate body plans, as well as some of the extraordinary specializations manifest in living forms. The instructors, who are both actively engaged in vertebrate-centered research, take this course beyond the boundaries of standard textbook content.

Instructor(s): M. Coates     Terms Offered: Winter. L.
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals sequence, including BIOS 20187 or BIOS 20235
Note(s): Offered Winter during even years. E.
Equivalent Course(s): ORGB 30250, EVOL 30200

BIOS 22260. Vertebrate Structure and Function. 100 Units.

This course is devoted to vertebrate bones and muscles, with a focus on some remarkable functions they perform. The first part takes a comparative look at the vertebrate skeleton via development and evolution, from lamprey to human. The major functional changes are examined as vertebrates adapted to life in the water, on land, and in the air. The second part looks at muscles and how they work in specific situations, including gape-feeding, swimming, leaping, digging, flying, and walking on two legs. Dissection of preserved vertebrate specimens required.

Instructor(s): P. Sereno. L.     Terms Offered: Spring
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals Sequence and consent of instructor. See also http://paulsereno.uchicago.edu/fossil_lab/classes/vertebrate_structure_and_function for more information.
Note(s): E.

BIOS 22265. Human Origins: Milestones in Human Evolution and the Fossil Record. 100 Units.

This course aims at exploring the fundamentals of human origins by tracking the major events during the course of human evolution. Starting with a laboratory based general introduction to human osteology and muscle function, the latest on morphological and behavioral evidence for what makes Homo sapiens and their fossil ancestors unique among primates will be presented. Our knowledge of the last common ancestor will be explored using the late Miocene fossil record followed by a series of lectures on comparative and functional morphology, adaptation and biogeography of fossil human species. With focus on the human fossil record, the emergence of bipedalism, advent of stone tool use and making, abandonment of arboreality, advent of endurance walking and running, dawn of encephalization and associated novel life histories, language and symbolism will be explored. While taxonomic identities and phylogenetic relationships will be briefly presented, the focus will be on investigating major adaptive transitions and how that understanding helps us to unravel the ecological selective factors that ultimately led to the emergence of our species. The course will be supported by fresh data coming from active field research conducted by Prof. Alemseged and state of the art visualization methods that help explore internal structures. By tracing the path followed by our ancestors over time, this course is directly relevant to reconnoitering the human condition today and our place in nature.

Instructor(s): Z. Alemseged. L.     Terms Offered: Autumn. Offered every other Autumn, even years.
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals Sequence, or consent of Instructor.
Note(s): E.
Equivalent Course(s): ANTH 28110, ORGB 33265

BIOS 22270. Bones and Genes: The Story of Homo Sapiens. 100 Units.

The primary aim of this course is to explore the biological and behavioral makings of our species, anatomically modern Homo sapiens, by considering hypotheses, models, evidence, and the latest consensus from the complementary fields of paleoanthropology and genetics. The course is divided into two blocks, one focusing on our origins and the other on migrations across the globe. After a brief introduction to the human skeleton, students will learn about the pool of potential direct ancestors that lived before Homo sapiens emerged 300,000 year ago, as well as the environmental and cultural environments that may have led to the arrival of our species. This will be complemented by an evaluation of competing genetic models for the origin of our species and evidence for genetic intermixing with archaic humans such as Neanderthals and Denisovans. We will, then, follow modern humans out of Africa and study the fossil, archaeological, and genetic evidence for the peopling of the planet and adaptations to novel environments. Finally, the contributions of paleoanthropology and genetics to our understanding of behavior, cognition, physical traits/phenotypes, diet, and disease evolution will be explored. Complementary laboratory and discussion sessions will expose students to state-of-the-art methods and current research endeavors in these fields.

Instructor(s): M. Raghavan, Z. Alemseged.      Terms Offered: Spring. L. This course will be taught during even years.
Prerequisite(s): BIOS Majors: Three quarters of a Biological Sciences Fundamentals Sequence. Also open to students in Anthropology and Genetics with an interest in human evolution, or consent of instructors.
Note(s): E.

BIOS 22306. Evolution and Development. 100 Units.

The course will provide a developmental perspective on animal body plans in phylogenetic context. The course will start with a few lectures, accompanied by reading assignments. Students will be required to present a selected research topic that fits the broader goal of the course and will be asked to submit a referenced written version of it after their oral presentation. Grading will be based on their presentation (oral and written) as well as their contributions to class discussions. Prerequisite(s): Advanced undergraduates may enroll with the consent of the instructor.

Instructor(s): U. Schmidt-Ott     Terms Offered: Spring
Prerequisite(s): Advanced undergraduates may enroll with the consent of the instructor.
Note(s): E.
Equivalent Course(s): ORGB 33850, DVBI 33850, EVOL 33850

BIOS 23232. Ecology and Evolution in the Southwest. 100 Units.

This lecture course focuses on the ecological communities of the Southwest, primarily on the four subdivisions of the North American Desert, the Chihuahuan, Sonoran, Mohave, and Great Basin Deserts. Lecture topics include climate change and the impact on the flora and fauna of the region; adaptations to arid landscapes; evolutionary, ecological, and conservation issues in the arid Southwest, especially relating to isolated mountain ranges; human impacts on the biota, land, and water; and how geological and climatic forces shape deserts.

Instructor(s): E. Larsen     Terms Offered: Spring
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals Sequence, or consent of instructor
Note(s): E.

BIOS 23233. Ecology and Evolution in the Southwest:Field School. 100 Units.

This lecture/lab course is the same course as BIOS 23232, but includes a lab section preparatory to a three-week field trip at end of Spring Quarter, specific dates to be announced. Our goal in the lab is to prepare proposals for research projects to conduct in the field portion of this course. Field conditions are rugged. Travel is by fifteen-passenger van. Lodging during most of this course is tent camping on developed campsites.

Instructor(s): E. Larsen     Terms Offered: Spring
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals Sequence and consent of instructor
Note(s): E.

BIOS 23247. Bioarchaeology and Forensic Anthropology: Approaches to the Past. 100 Units.

This course is intended to provide students with a thorough understanding of bioanthropological, osteological and forensic methods used in the interpretation of past and present behavior by introducing osteological methods and anthropological theory. In particular, lab instruction stresses hands-on experience in analyzing human remains, whereas seminar classes integrate bioanthropological theory and its application to specific archaeological and forensic cases throughout the world. At the end of this course, students will be able to identify, document, and interpret human remains from archaeological and forensic contexts. Lab and seminar-format classes each meet weekly.

Note(s): This course qualifies as a Methodology selection for Anthropology majors.
Equivalent Course(s): ANTH 38800, ANTH 28400, LACS 28400, LACS 38400

BIOS 23248. Primate Behavior and Ecology. 100 Units.

This course explores the behavior and ecology of nonhuman primates with emphasis on their natural history and evolution. Specific topics include methods for the study of primate behavior, history of primate behavior research, socioecology, foraging, predation, affiliation, aggression, mating, parenting, development, communication, cognition, and evolution of human behavior.

Instructor(s): D. Maestripieri     Terms Offered: Autumn
Prerequisite(s): Completion of the first three quarters of a Biological Sciences fundamentals sequence.
Note(s): E.
Equivalent Course(s): CHDV 21800, CHDV 34300, EVOL 37300

BIOS 23249. Animal Behavior. 100 Units.

This course introduces the mechanism, ecology, and evolution of behavior, primarily in nonhuman species, at the individual and group level. Topics include the genetic basis of behavior, developmental pathways, communication, physiology and behavior, foraging behavior, kin selection, mating systems and sexual selection, and the ecological and social context of behavior. A major emphasis is placed on understanding and evaluating scientific studies and their field and lab techniques.

Instructor(s): J. Mateo (odd years)     Terms Offered: Winter
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals Sequence.
Note(s): CHDV Distribution: A E.
Equivalent Course(s): CHDV 23249, PSYC 23249

BIOS 23254. Mammalian Ecology. 100 Units.

This course introduces the diversity and classification of mammals and their ecological relationships. Lectures cover natural history, evolution, and functional morphology of major taxonomic groups. Lab sessions focus on skeletal morphology, identifying traits of major taxonomic groups, and methods of conducting research in the field. Participation in field trips, occasionally on Saturday, is required.

Instructor(s): E. Larsen     Terms Offered: Spring. L. Offered every other year in odd years.
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals Sequence and third-year standing or consent of instructor.
Note(s): E.

BIOS 23261. Invertebrate Paleobiology and Evolution. 100 Units.

This course provides a detailed overview of the morphology, paleobiology, evolutionary history, and practical uses of the invertebrate and microfossil groups commonly found in the fossil record. Emphasis is placed on understanding key anatomical and ecological innovations within each group and interactions among groups responsible for producing the observed changes in diversity, dominance, and ecological community structure through evolutionary time. Labs supplement lecture material with specimen-based and practical application sections. An optional field trip offers experience in the collection of specimens and raw paleontological data. Several "Hot Topics" lectures introduce important, exciting, and often controversial aspects of current paleontological research linked to particular invertebrate groups. (L)

Instructor(s): M. Webster     Terms Offered: Autumn
Prerequisite(s): GEOS 13100 and 13200 or equivalent; completion of the general education requirement in the Biological Sciences, or consent of instructor.
Equivalent Course(s): GEOS 36300, GEOS 26300, EVOL 32400

BIOS 23262. Mammalian Evolutionary Biology. 100 Units.

This course examines mammalian evolution-the rise of living mammals from ancient fossil ancestors stretching back over 300 million years. Lectures focus on the evolutionary diversification of mammals, including anatomical structure, evolutionary adaptations, life history, and developmental patterns. Labs involve detailed comparative study of mammalian skeletons, dissection of muscular and other systems, trips to the Field Museum to study fossil collections, and studies of human anatomy at the Pritzker School of Medicine. Students will learn mammalian evolution, functional morphology, and development, and will gain hands-on experience in dissection. Taught by instructors who are active in scientific research on mammalian evolution, the course is aimed to convey new insights and the latest progress in mammalian paleontology, functional morphology, and evolution. Prerequisite(s): Second-year standing and completion of a Biological Sciences Fundamentals sequence; or GEOS 13100-13200 or GEOS 22300, or consent of instructors.

Instructor(s): Z. Luo, K. Angielczyk     Terms Offered: Autumn. L.
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals Sequence or consent of instructors.
Note(s): E.
Equivalent Course(s): ORGB 31201, EVOL 31201

BIOS 23266. Evolutionary Adaptation. 100 Units.

This course deals with the adaptation of organisms to their environments and focuses on methods for studying adaptation. Topics include definitions and examples of adaptation, the notion of optimization, adaptive radiations, the comparative method in evolutionary biology, and the genetic architecture of adaptive traits. Students will draw on the logical frameworks covered in lecture as they evaluate primary papers and prepare a writing assignment on an adaptive question of their choice.

Instructor(s): C. Andrews     Terms Offered: Autumn
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals Sequence including BIOS 20153 and BIOS 20187 or BIOS 20234 and 20235 or BIOS 20170 and 20171 or consent of instructor.
Note(s): E.

BIOS 23289. Marine Ecology. 100 Units.

This course provides an introduction into the physical, chemical, and biological forces controlling the function of marine ecosystems and how marine communities are organized. The structures of various types of marine ecosystems are described and contrasted, and the lectures highlight aspects of marine ecology relevant to applied issues such as conservation and harvesting.

Instructor(s): T. Wootton     Terms Offered: Winter
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals Sequence and prior introductory course in ecology or consent of instructor.
Note(s): E.
Equivalent Course(s): ENST 23289

BIOS 23299. Plant Development and Molecular Genetics. 100 Units.

Genetic approaches to central problems in plant development will be discussed. Emphasis will be placed on embryonic pattern formation, meristem structure and function, reproduction, and the role of hormones and environmental signals in development. Lectures will be drawn from the current literature; experimental approaches (genetic, cell biological, biochemical) used to discern developmental mechanisms will be emphasized. Graduate students will present a research proposal in oral and written form; undergraduate students will present and analyze data from the primary literature, and will be responsible for a final paper.

Instructor(s): J. Greenberg     Terms Offered: Spring
Prerequisite(s): For undergraduates only: Three quarters of a Biological Sciences Fundamentals Sequence including BIOS 20187 or BIOS 20235.
Note(s): E.
Equivalent Course(s): ECEV 32900, MGCB 36100, DVBI 36100

BIOS 23404. Reconstructing the Tree of Life: An Introduction to Phylogenetics. 100 Units.

This course is an introduction to the tree of life (phylogeny): its conceptual origins, methods for discovering its structure, and its importance in evolutionary biology and other areas of science. Topics include history and concepts, sources of data, methods of phylogenetic analysis, and the use of phylogenies to study the tempo and mode of lineage diversification, coevolution, biogeography, conservation, molecular biology, development, and epidemiology. One Saturday field trip and weekly computer labs required in addition to scheduled class time. This course is offered in alternate (odd) years.

Instructor(s): R. Ree.; A. Hipp     Terms Offered: Autumn. This course is offered in alternate (odd) years. L.
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals Sequence or consent of instructor
Note(s): E. CB.
Equivalent Course(s): EVOL 35401

BIOS 23406. Biogeography. 100 Units.

In this course, we examine the uneven distribution of life on Earth and how ecology, evolution, and Earth sciences help us understand its past, present, and future. Topics include diversity gradients and hotspots, islands, methods for inferring the boundaries and histories of biotas, models and laws in biogeography, and the relevance of biogeography in the Anthropocene.

Instructor(s): J. Bates (odd years- Autumn); R. Ree (odd years- Winter)     Terms Offered: Autumn Winter. Offered during odd calendar years only, Winter & Autumn.
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals sequence and a course in either ecology, evolution, or earth history; or consent of instructor
Note(s): E. GP.
Equivalent Course(s): ENST 25500, GEOG 35500, GEOG 25500, EVOL 45500

BIOS 23409. The Ecology and Evolution of Infectious Diseases. 100 Units.

Understanding the ecology and evolution of infectious diseases is crucial for both human health and for preservation of the natural environment. In this course, we combine mathematical modeling with ecological and evolutionary analyses to understand how fundamental mechanisms of host-pathogen interactions are translated into disease dynamics and host-pathogen co-evolution.

Instructor(s): G. Dwyer     Terms Offered: Spring. L.
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals Sequence and Integral calculus.
Note(s): E. GP. CB.

BIOS 23410. Complex Interactions: Coevolution, Parasites, Mutualists, and Cheaters. 100 Units.

This course emphasizes the enormous diversity of interactions between organisms. It is an introduction to the biology and ecology of parasitic and mutualistic symbiotic associations and their evolution. Topics include endosymbioses and their impact on the evolution of photosynthetic organisms, bacterial symbioses (e.g., nitrogen fixation), symbioses that fungi evolved with plants and animals (e.g., endophytes, mycorrhizae, lichens), pollination biology, insect-plant associations, and associations of algae with animals. Methods to elucidate the evolution of these associations are discussed with a focus on coevolutionary events and the origin of cheaters.

Instructor(s): T. Lumbsch     Terms Offered: Spring
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals sequence.
Note(s): E.

BIOS 23413. Quantitative Microbial Ecology. 100 Units.

Microbes live in nearly every niche on the planet from our bodies to the soil beneath our feet. In all of these habitats, microbes live in communities that harbor staggering complexity with thousands of species possessing almost unimaginable variation in traits and interactions. From all of this complexity emerge global nutrient cycles, the functional microbiota within higher organisms, and many industrial processes upon which life depends. In recent years ecologists and microbiologists have joined forces with physicists, engineers, chemists, and computer scientists to try and build quantitative and predictive formalisms to understand these systems. This course gives students a front-row seat to this emerging field through a "physics-style approach" to understand the structure, dynamics, and function of complex communities of microbes. We engage with the general principles of microbial physiology. These considerations connect our inquiry to consumer-resource models and computational studies of resource-mediated interactions in microbial communities.

Instructor(s): Seppe Kuehn     Terms Offered: Spring
Prerequisite(s): Calculus. Basic familiarity with programming in Python, Matlab or R is beneficial but not required. Biology majors: Completion of three quarters of a Biological Sciences Fundamentals sequence.
Equivalent Course(s): ECEV 36500

BIOS 24130. Systems Neuroscience. 100 Units.

This course covers vertebrate and invertebrate systems neuroscience with a focus on the anatomy, physiology, and development of sensory and motor control systems. The neural bases of form and motion perception, locomotion, memory, and other forms of neural plasticity are examined in detail. We also discuss clinical aspects of neurological disorders.

Instructor(s): J. MacLean     Terms Offered: Spring
Prerequisite(s): NSCI 20101, NSCI 20111 or consent of instructors
Equivalent Course(s): NSCI 20130, PSYC 24010

BIOS 24217. Conquest of Pain. 100 Units.

This course examines the biology of pain and the mechanisms by which anesthetics alter the perception of pain. The approach is to examine the anatomy of pain pathways both centrally and peripherally, and to define electrophysiological, biophysical, and biochemical explanations underlying the action of general and local anesthetics. We discuss the role of opiates and enkephalins. Central theories of anesthesia, including the relevance of sleep proteins, are also examined.

Instructor(s): K. Ruskin     Terms Offered: Winter
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals Sequence, CHEM 2200-22100-22200 or BIOS 20200 and prior course in neurobiology or physiology is recommended.
Equivalent Course(s): NSCI 22450

BIOS 24231. Methods in Computational Neuroscience. 100 Units.

Topics include (but are not limited to): relating neural data to behavior, Signal Detection theory, models of vision and artificial neural networks, Information Theory, Generalized Linear Models, dimensionality reduction, classification, and clustering.

Instructor(s): M. Kaufman     Terms Offered: Spring
Prerequisite(s): For Neuroscience Majors: NSCI 20130, BIOS 26210 and BIOS 26211 which must be taken concurrently, or consent of instructor.
Note(s): CB.
Equivalent Course(s): CPNS 34231, NSCI 23700, PSYC 24231

BIOS 24248. Biological Clocks and Behavior. 100 Units.

This course will address physiological and molecular biological aspects of circadian and seasonal rhythms in biology and behavior. The course will primarily emphasize biological and molecular mechanisms of CNS function, and will be taught at a molecular level of analysis from the beginning of the quarter. Those students without a strong biology background are unlikely to resonate with the course material.

Instructor(s): B. Prendergast     Terms Offered: Winter
Prerequisite(s): A quality grade in PSYC 20300 Introduction to Biological Psychology. Additional biology courses are desirable. Completion of Core biology will not suffice as a prerequisite.
Equivalent Course(s): PSYC 21750, HLTH 21750, NSCI 21400

BIOS 24251. Neurons and Glia: A Cellular and Molecular Perspective. 100 Units.

This course will be an interactive, in-depth analysis of the cell biology of neurons and glia. We will learn and discuss the latest techniques used, for example, to study the structure and function of neuronal proteins. In this way we will illuminate the central concepts that define our understanding of the cell and molecular biology of neurons and glia. The course will consist of lectures and critical reading of contemporary literature.

Instructor(s): R. Carrillo; W. Green     Terms Offered: Spring
Prerequisite(s): Neuroscience Majors: NSCI 20101-20130 (Fundamental Neuroscience Sequence) Biological Sciences Majors: NSCI 20101-20130, or three quarters of a Biological Sciences Fundamentals Sequence
Equivalent Course(s): NURB 34810, NSCI 23810

BIOS 24408. Modeling and Signal Analysis for Neuroscientists. 100 Units.

The course provides an introduction into signal analysis and modeling for neuroscientists. We cover linear and nonlinear techniques and model both single neurons and neuronal networks. The goal is to provide students with the mathematical background to understand the literature in this field, the principles of analysis and simulation software, and allow them to construct their own tools. Several of the 90-minute lectures include demonstrations and/or exercises in Matlab.

Instructor(s): W. van Drongelen     Terms Offered: Spring. L.
Prerequisite(s): Undergraduates: Biology Major - BIOS 26210 and 26211, or consent of instructor. Neuroscience Major - NSCI 20130, BIOS 26210 and 26211, or consent of instructor.
Note(s): CB.
Equivalent Course(s): NSCI 24000, CPNS 32111

BIOS 25108. Cancer Biology. 100 Units.

This course covers the fundamentals of cancer biology with a focus on the story of how scientists identified the genes that cause cancer. The emphasis is on "doing" science rather than "done" science: How do scientists think, how do they design experiments, where do these ideas come from, what can go wrong, and what is it like when things go right? We stress the role that cellular subsystems (e.g., signal transduction, cell cycle) play in cancer biology, as well as evolving themes in cancer research (e.g., ongoing development of modern molecular therapeutics).

Instructor(s): S. E. Elf; A. Muir     Terms Offered: Autumn
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals Sequence.
Note(s): GP.

BIOS 25109. Topics in Reproduction and Cancer. 100 Units.

This course focuses on several aspects of the molecular and cellular biology of human reproduction. We also discuss the basis of chemical/viral carcinogenesis and the progression, treatment, and prevention of cancer. The role of steroid hormones and their receptors in the control of growth, development, and specialized cell function is discussed in the context of normal and abnormal gene expression in human development and disease. Key historical events, research approaches, utilization of knowledge, recent advances in drug design and herbal medicines, and philosophies of scientific research are also covered.

Instructor(s): G. Greene, L. Becker     Terms Offered: Spring
Prerequisite(s): For Biology majors: Three quarters of a Biological Sciences Fundamentals Sequence including BIOS 20187 or BIOS 20235 and Biochemistry, or consent of Instructor.
Note(s): GP.

BIOS 25126. Animal Models of Human Disease. 100 Units.

This course introduces the use of animals in biomedical research for the purposes of understanding, treating, and curing human disease. Particular emphasis is placed on rodent models in the context of genetic, molecular, and immunologic manipulations, as well as on the use of large animal surgical models. University veterinarians also provide information regarding humane animal care.

Instructor(s): K. Luchins, A. Ostdiek     Terms Offered: Spring
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals Sequence including a course in genetics, or consent of instructor
Note(s): GP.

BIOS 25206. Fundamentals of Bacterial Physiology. 100 Units.

This course meets one of the requirements of the microbiology specialization. This course introduces bacterial diversity, physiology, ultra-structure, envelope assembly, metabolism, and genetics. In the discussion section, students review recent original experimental work in the field of bacterial physiology.

Instructor(s): L. Comstock     Terms Offered: Autumn
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals Sequence, or consent of instructor
Note(s): GP.
Equivalent Course(s): MICR 30600

BIOS 25207. Fundamentals and Applications of the Human Microbiota. 100 Units.

Thousands of microbes colonize the human body to collectively establish the human microbiota. Research findings over the past two decades have led to a growing appreciation of the importance of the microbiota in various facets of human health. This course will explore the human microbiota through a critical review of the primary scientific literature. The first portion of the course will cover distinct ways by which the human microbiota impacts mammalian health. The second part of the course will focus on established and developing microbiota-targeting biotechnologies. Students will leave the course with a general understanding of the current state of human microbiota research and its therapeutic and diagnostic applications.

Instructor(s): S. Light, M. Mimee     Terms Offered: Winter
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals Sequence. Third or fourth year standing or consent of instructor.
Note(s): GP.
Equivalent Course(s): MENG 23210, MENG 33210, MICR 38000

BIOS 25216. Molecular Basis of Bacterial Disease. 100 Units.

This course meets one of the requirements of the microbiology specialization. This lecture/discussion course involves a comprehensive analysis of bacterial pathogens, the diseases that they cause, and the molecular mechanisms involved during pathogenesis. Students discuss recent original experimental work in the field of bacterial pathogenesis.

Instructor(s): J. Chen     Terms Offered: Winter
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals Sequence.
Note(s): GP.
Equivalent Course(s): MICR 31600

BIOS 25226. Endocrinology I: Cell Signaling. 100 Units.

The subject matter of this course considers the wide variety of intracellular mechanisms that, when activated, change cell behavior. We cover aspects of intracellular signaling, the latter including detailed discussions of receptors, G-proteins, cyclic nucleotides, calcium and calcium-binding proteins, phosphoinositides, protein kinases, and phosphatases.

Instructor(s): M. Brady.     Terms Offered: Autumn
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals Sequence and BIOS 20200.
Equivalent Course(s): NPHP 33600

BIOS 25227. Endocrinology II: Systems and Physiology. 100 Units.

Endocrinology is the study of hormones, which are chemical messengers released by tissues that regulate the activity of other cells in the body. This course covers the classical hormone systems, including hormones regulating metabolism, energy mobilization and storage, calcium and phosphate metabolism, reproduction, growth, "fight or flight," and circadian rhythms. We focus on historical perspective, the mechanisms of action, homeostatic regulation, and relevant human diseases for each system.

Instructor(s): M. Brady, R. Cohen     Terms Offered: Winter
Prerequisite(s): Completion of the first three quarters of a Biological Fundamentals Sequence.
Note(s): GP.

BIOS 25228. Endocrinology III: Human Disease. 100 Units.

A Fundamentals Sequence (BIOS 20180s or 20190s, or AP 5 sequence) and BIOS 25227 recommended but not required. This course is a modern overview of the patho-physiologic, genetic, and molecular basis of human diseases with nutritional perspectives. We discuss human diseases (e.g., hypertension, cardiovascular diseases, obesity, diabetes, osteoporosis, alopecia).

Instructor(s): Y. C. Li     Terms Offered: Spring
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals Sequence is required and BIOS 25227 is strongly recommended.
Note(s): GP.

BIOS 25256. Immunobiology. 100 Units.

This comprehensive survey course presents an integrated coverage of the tactics and logistics of innate and adaptive immunity in mammalian organisms. It conveys the elegance and complexity of immune responses against infectious agents. It introduces their implications in autoimmune diseases, cancer and organ transplantation and presents some of the emerging immunotherapeutics that are transforming health care. Prior knowledge of microbiology (e.g., BIOS 25206) will be advantageous. Prerequisite(s): Completion of a Biological Sceinces Fundamentals Sequence which includes, Cell, Genetics, Developmental Biology, and Physiology

Instructor(s): M. Alegre     Terms Offered: Autumn
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals Sequence including BIOS 20187 or BIOS 20235, and BIOS 20188 and BIOS 20189
Note(s): GP.

BIOS 25258. Immunopathology. 100 Units.

Five examples of diseases are selected each year among the following categories: autoimmune diseases, inflammatory bowel diseases, infection immunity, immunodeficiencies and gene therapy, and transplantation and tumor immunology. Each disease is studied in depth with general lectures that include, where applicable, histological analysis of diseased tissue samples and discussions of primary research papers on experimental disease models. Special emphasis is placed on understanding immunopathology within the framework of general immunological concepts and on experimental approaches to the study of immunopathological models.

Instructor(s): D. Esterhazy; RR. Chowdhury     Terms Offered: Winter
Prerequisite(s): BIOS 25256 with a grade of B or higher.
Note(s): GP.
Equivalent Course(s): IMMU 30010, PATH 30010

BIOS 25260. Host Pathogen Interactions. 100 Units.

This course explores the basic principles of host defense against pathogens, including evolutionary aspects of innate and adaptive immunity and immune evasion strategies. Specific examples of viral and bacterial interactions with their hosts are studied in depth. A review of immunological mechanisms involved in specific cases is incorporated in the course.

Instructor(s): A. Chervonsky     Terms Offered: Autumn
Prerequisite(s): BIOS 25206 and BIOS 25256
Note(s): GP.
Equivalent Course(s): MICR 31200, IMMU 31200

BIOS 25266. Molecular Immunology. 100 Units.

This discussion-oriented course examines the molecular principles of immune recognition. We explore the roles of protein modification, protein-protein and protein-DNA interactions in the discrimination between self and non-self, and study the molecular fundamentals of cell stimulation and signaling. Primary literature focused on molecular research of the immune system is integrated with lectures on commonly used biochemical, structural and immunological techniques used in the research papers examined.

Instructor(s): E. Adams     Terms Offered: Spring. Offered in odd years
Prerequisite(s): BIOS 20200 or 25256, or consent of instructor. Offered during odd years.
Equivalent Course(s): IMMU 30266

BIOS 25287. Introduction to Virology. 100 Units.

This class on animal viruses considers the major families of the viral kingdom with an emphasis on the molecular aspects of genome expression and virus-host interactions. Our goal is to provide students with solid appreciation of basic knowledge, as well as instruction on the frontiers of virus research.

Instructor(s): T. Golovkina     Terms Offered: Spring
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals Sequence and third- or fourth-year standing
Note(s): GP.
Equivalent Course(s): MICR 34600

BIOS 25308. Heterogeneity in Human Cancer: Etiology and Treatment. 100 Units.

This course addresses the importance of understanding human tumor heterogeneity (organ site by organ site) in terms of predicting whether tumors will progress to malignancy and how tumors will respond to standard treatments or require tailored molecular therapeutics. Alternating lecture and discussion lectures will explore and tease apart the controversies in the field that limit progress in cancer prevention, diagnosis and treatment. At the end of the course, students should have an in-depth understanding of the complexities, challenges and opportunities facing modern cancer researchers and clinical oncologists and be able to discuss novel scientific approaches to solving these issues.

Instructor(s): K. MacLeod     Terms Offered: Winter
Prerequisite(s): A grade of B or better in BIOS 25108
Note(s): GP.

BIOS 25326. Tumor Microenvironment and Metastasis. 100 Units.

The tumor microenvironment regulates disease progression and chemoresistance in most cancers. This course addresses the functional contribution of the different cellular and non-cellular constituents of the tumor that surround the malignant cancer cells in cancer progression and metastasis. We will thoroughly discuss the function of stroma, inflammation, tumor senescence, immunity and the interactome in cancer progression and metastasis. Moreover, we will evaluate the translational impact of targeting the tumor microenvironment. Laboratory studies will introduce key techniques and organotypic model systems to elucidate these functions. At the end of the course, students should be able to understand the biology behind cancer metastasis and to evaluate manuscripts reporting novel findings in cancer biology. Prerequisite(s): BIOS 25108 and BIOS 25308

Instructor(s): H. Kenny, E. Lengyel     Terms Offered: Spring
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals Sequence.
Note(s): Three optional weekend, one-day workshops will be offered during the quarter. This course qualifies in the Cancer Specialization.

BIOS 25327. Health Disparities in Breast Cancer. 100 Units.

Across the globe, breast cancer is the most common women's cancer. In the last two decades, there have been significant advances in breast cancer detection and treatment that have resulted in improved survival rates. Yet, not all populations have benefited equally from these improvements, and there continues to be a disproportionate burden of breast cancer felt by different populations. In the U.S., for example, white women have the highest incidence of breast cancer but African-American women have the highest breast cancer mortality overall. The socioeconomic, environmental, biological, and cultural factors that collectively contribute to these disparities are being identified with a growing emphasis on health disparities research efforts. In this 10-week discussion-based course students will meet twice weekly and cover major aspects of breast cancer disparities.

Instructor(s): E. Dolan, S. Conzen     Terms Offered: Winter
Prerequisite(s): BIOS 25108
Note(s): GP.
Equivalent Course(s): HLTH 20400, CCTS 20400, GNSE 30408, CCTS 40400, GNSE 20408

BIOS 25328. Cancer Genetics and Genomics. 100 Units.

Unprecedented technological progress over the last decade, especially high throughput sequencing technologies, has transformed the basic and translational research of cancer as well as other diseases. In this course, we will introduce the current state of the field, discuss how germline and somatic factors drive cancer initiation and progression, and demonstrate how to use omics data to advance our understanding of cancer. We will review recent literature in cancer genetics and genomics, learn about the standing questions in the field, and practice the analytical techniques to address these questions. Computational exercises will be an integral part of the course and provide you with a hand-on experience of state-of-the-art techniques.

Instructor(s): H.K. Im, L. Yang     Terms Offered: Spring
Prerequisite(s): BIOS 20187, BIOS 20152 or equivalent
Note(s): CB.

BIOS 25329. Tissue Immunity and Cancer. 100 Units.

This course explores classical and contemporary cancer immunology and immunotherapy concepts. It covers fundamental knowledge in cancer immunity, immune evasion, and immunotherapy design through lectures and primary literature reviews. The unique aspect of this course is its focus on tissue-specific immunity and how it impacts tumor surveillance or aids cancer progression. This perspective leads students to the forefront of cancer research, investigating why tumors vary in aggressiveness across different tissues and why treatments differ in effectiveness. Students will also learn about the principles of adaptive and innate immune system coordination against tumorigenesis and how these systems can be manipulated to facilitate or hinder tumor progression. The course uses colon, skin, and pancreas as examples to illustrate how various tissues establish distinct immune-cancer interactions, leading to diverse responses against primary or metastatic tumors and promoting cancer immune evasion. Additionally, the course discusses advancements in cancer immunotherapy, spanning pre-clinical and clinical testing stages, with an emphasis on using tissue-specific immunity to design optimal treatments. Students will be assessed through in-class discussions, take-home assignments, exams, and an end-of-term project on a topic of their choice.

Instructor(s): D. Esterhazy and Y. Miao     Terms Offered: Spring
Prerequisite(s): Three quarters of a biology fundamentals sequence and one of the following: BIOS 25108 Cancer Biology, BIOS 25256 Immunobiology, or BIOS 25258 Immunopathology.
Note(s): This course counts as a required course in the Immunology Specialization for biology majors.

BIOS 25426. From Diagnostics to Therapy: The Application of Translational Research in Cancer. 100 Units.

With the tremendous strides in medicine and healthcare, cancer is still a leading cause of mortality worldwide. Why is this? Cancer is a complex disease, which ultimately makes treatment challenging. Reasons for this disease complexity include the cancer origin/type; impact of cancer heterogeneity; complex interactions between cell types within the tumor microenvironment; tendency of disease to recur; and whether metastasis has occurred. Although cancer is still a major problem, there is hope founded on the recent advancements in technology/methodology in cancer diagnosis/treatments, which translational research has a significant role. In this course, students will learn about what cancer is and the characteristics that make it a complex disease. Translational research and its role in increasing the cure rate/prolonging survival will be defined. The course will cover the advancements in cancer diagnostics from imaging, sequencing, body fluids, and digital pathology using machine learning. The course will also include introducing methods of long-term monitoring of cancer progression/relapse and dynamic evaluation of the treatment effectiveness. Novel cancer treatments based on successes in translational research will be presented. Guest speakers that are experts in fields of cancer diagnostics, clinical pathology, and immunology will provide lectures on relevant topics pertaining to application of translational research to improve cancer patient outcomes.

Instructor(s): E. Izumchenko and R. Bednarczyk     Terms Offered: Spring
Prerequisite(s): Three quarters of a biology fundamentals sequence.

BIOS 26120. An Introduction to Bioinformatics and Proteomics. 100 Units.

Modern biology generates massive amounts of data; this course is devoted to biological information and the models and techniques used to make sense of it. Students learn about biological databases, algorithms for sequence alignment, phylogenetic tree building, and systems biology. They will also learn about the basics of large-scale study of proteins, particularly their structures and functions. Students will be introduced to basics of high performance computation (HPC) and its application to the field of bioinformatics. They will learn how to use our in-house Super Computer to process and analyze next generation sequencing data. Using state of the art tools, students will align and genotype a group of genes in order to identify disease-relevant variants. The course will be taught as a hands on computer approach (a computation background would be helpful, but not needed).

Instructor(s): E. Haddadian     Terms Offered: Autumn. L.
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals Sequence or BIOS 20172 or consent of Instructor. No computation background required.
Note(s): CB.

BIOS 26121. Introduction to Transcriptomics. 100 Units.

Transcriptomics is the study of the transcriptome -the complete set of RNA or transcripts that are produced by the genome, using high-throughput methods. In this course, students will learn about modern techniques used to capture and analyze mRNA and the connections of transcriptomics to epi-genomics (study of the epi-genome) and proteomics (study of proteins). The course will be divided into three parts: 1) Introduction of technologies that generate transcriptomics data, 2) Statistical analysis of the data, and 3) Case studies and applications. A range of topics relevant to the current practices in the field will be discussed, including introduction to microarrays, Next-Generation Sequencing (NGS), bulk and single-cell RNA processing, machine learning techniques used in data analyses, data pre-processing, differential expression analysis, and correcting batch effects and other experimental artifacts. Students will obtain hands-on experience in downloading public-domain data and performing analyses using different packages written in R and Python. After taking the class, students will have a working knowledge of the field and acquire experience in RNA-seq data analyses that are currently used in research labs. We will also organize visits to research laboratories and sequencing facility for the students to observe experimental workflows used in cutting-edge research.

Instructor(s): A. Basu, M. Chen     Terms Offered: Winter
Prerequisite(s): BIOS 20151 Intro to Quantitative Modeling or BIOS 20152 Intro to Quantitative Modeling (Adv.)
Note(s): CB.

BIOS 26122. Introduction to Machine Learning for Biology. 100 Units.

Machine learning techniques are essential in many fields of biology that rely on large amounts of data. This course is intended to introduce key concepts in this field and illustrate their applications to biological questions. Students will learn about methods for supervised and unsupervised learning; regression and classification algorithms, and dimensionality reduction approaches. With every method we will emphasize model selection and validation on real data sets. Computational labs are an integral part of the course for students to work on applying these methods using R in the Quarto document system.

Instructor(s): D. Kondrashov     Terms Offered: Winter
Prerequisite(s): BIOS 20151, BIOS 20172 or BIOS 20236. STAT 22000 or equivalent.
Note(s): L. CB.
Equivalent Course(s): NSCI 27710, NSCI 21710

BIOS 26123. Introduction to Python for Biologists & Neuroscientists. 100 Units.

This course aims to provide a basis for solving problems in biology and neuroscience using the Python Programing Language. You will learn how to utilize Jupyter notebooks to code in python. By the end of the course you will develop comfortability in utilizing key Python libraries for biological and/or neuroscience datasets. No prior knowledge of Python is expected or required.

Instructor(s): R. Dutt     Terms Offered: Winter
Equivalent Course(s): NSCI 21820

BIOS 26210-26211. Mathematical Methods for Biological Sciences I-II.

The following two courses are intended to be taken as a sequence.

BIOS 26210. Mathematical Methods for Biological Sciences I. 100 Units.

This course builds on the introduction to modeling course biology students take in the first year (BIOS 20151 or 152). It begins with a review of one-variable ordinary differential equations as models for biological processes changing with time, and proceeds to develop basic dynamical systems theory. Analytic skills include stability analysis, phase portraits, limit cycles, and bifurcations. Linear algebra concepts are introduced and developed, and Fourier methods are applied to data analysis. The methods are applied to diverse areas of biology, such as ecology, neuroscience, regulatory networks, and molecular structure.The students learn to implement the models using Python in the Jupyter notebook platform.

Instructor(s): D. Kondrashov     Terms Offered: Autumn. L.
Prerequisite(s): BIOS 20151 or BIOS 20152 or equivalent quantitative experience by consent of instructor, and three courses of a Biological Sciences Fundamentals Sequence or consent of the instructor.
Equivalent Course(s): PSYC 36210, CPNS 31000

BIOS 26211. Mathematical Methods for Biological Sciences II. 100 Units.

This course is a continuation of BIOS 26210. The topics start with optimization problems, such as nonlinear least squares fitting, principal component analysis and sequence alignment. Stochastic models are introduced, such as Markov chains, birth-death processes, and diffusion processes, with applications including hidden Markov models, tumor population modeling, and networks of chemical reactions. In computer labs, students learn optimization methods and stochastic algorithms, e.g., Markov Chain, Monte Carlo, and Gillespie algorithm. Students complete an independent project on a topic of their interest.

Instructor(s): D. Kondrashov     Terms Offered: Winter. L.
Prerequisite(s): BIOS 26210 or equivalent.
Note(s): CB.
Equivalent Course(s): PSYC 36211, CPNS 31100

BIOS 26318. Fundamentals of Biological Data Analysis. 100 Units.

This course is intended for students who have original data from a research project and are looking to produce a thesis or publication. Students will learn to organize, process, visualize, and make inferences from biological data sets using the data processing tools of R. We will review statistics concepts, such as probability distributions, linear and nonlinear fitting, estimation and hypothesis testing, and introduce new concepts relevant for the specific research questions identified by the students. The end result will be a written report that can function as a methods and results section of a research publication and contains high-quality graphics.

Instructor(s): D. Kondrashov, S. Allesina     Terms Offered: Autumn. L.
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals Sequence, STAT 22000 or higher, and fourth-year standing, or consent of Instructor. Primarily intended for students that have a data set from original research.
Note(s): CB.

BIOS 26403. Quantitative Immunobiology. 100 Units.

The science of immunology was born at the end of the 19th century as a discipline focused on the body's defenses against infection. The following 120+ years has led to the discovery of a myriad of cellular and molecular players in immunity, placing the immune system alongside the most complex systems such as Earth's global climate and the human brain. The functions and malfunctions of the immune system have been implicated in virtually all human diseases. It is thought that cracking the complexity of the immune system will help manipulate and engineer it against some of the most vexing diseases of our times such as AIDS and cancer. To tackle this complexity, immunology in the 21st century - similar to much of the biological sciences - is growing closer to mathematics and data sciences, physics, chemistry and engineering. A central challenge is to use the wealth of large datasets generated by modern day measurement tools in biology to create knowledge, and ultimately predictive models of how the immune system works and can be manipulated. The goal of this course is to introduce motivated students to the quantitative approaches and reasoning applied to fundamental questions in immunology.

Instructor(s): Nicolas Chevrier      Terms Offered: Winter
Prerequisite(s): Completion of the first two quarters of a Biological Sciences Fundamentals Sequence. Knowledge of R is recommended but not required. Courses in immunology and microbiology are an advantage but not required (e.g., BIOS 25256 Immunobiology; BIOS 25206 Fundamentals of Bacterial Physiology).
Note(s): CB
Equivalent Course(s): MENG 23300, IMMU 34800, MENG 33300

BIOS 26404. Quantitative Genetics for the 21st Century. 100 Units.

This course has three parts. In the first four weeks, we take a deep look at some fundamentals of quantitative genetics, focusing on underlying mathematical theory and causal interpretations of basic quantitative genetic models. These include the breeder's equation and related descriptions of the response to natural selection, various methods of estimating heritability, GWAS methods accounting for environmental effects, and explicit causal inference methods like Mendelian randomization. In the next three weeks of the course, we discuss the scientific opportunities and pitfalls of applying these fundamental quantitative genetic tools in challenging settings. This section covers phenotypic prediction with polygenic scores, inferences about quantitative trait evolution, and the application of quantitative genetic tools to complex social traits like educational attainment. Finally, in the third section we examine the relationship between race, genetics, and complex traits. In this section we discuss definitions of race and how they are (or are not) related to genetics, as well as ongoing legitimate scientific debates over how racial classifications are used in medicine. We will also critique pseudoscientific arguments about the relationship between race, genetics and complex traits.

Instructor(s): Jeremy Berg, Andrew Dahl      Terms Offered: Spring
Prerequisite(s): R/Python proficiency.
Equivalent Course(s): HGEN 47800

BIOS 26405. From Data to Understanding: Computational Biology in Microbial Ecosystems. 100 Units.

This course focuses on transforming biology from descriptive to predictive science through quantitative data analysis. Central to this shift are statistical, mathematical, and computing tools. Students will learn to extract meaning from data, understanding both what it reveals and its limitations. The course isn't about machine learning, statistics, or mathematical modeling per se. Instead, it emphasizes how these tools help us interpret data. We'll explore these concepts through the practical problem of identifying significant dynamics and patterns in data. Our learning context is microbial communities, ubiquitous across various habitats and exhibiting immense complexity and diversity. Despite advances in DNA sequencing, predicting and controlling these systems remains challenging. This course combines insights from ecology, microbiology, physics, engineering, chemistry, and computer science to build quantitative, predictive models for these complex systems. Students will be introduced to forefront methods and questions in this evolving field, focusing on computational data analysis.

BIOS 27710-27711-27712-27713-27714-27715. MARINE BIOLOGICAL LABORATORY SEMESTER IN ENVIRONMENTAL SCIENCE.

Marine Biological Laboratory Semester in Environmental Science Sequence (SES). Courses BIOS 27710-27715 are the College designations for the Semester in Environmental Science that is taught at the Marine Biological Laboratory (MBL) in Woods Hole, Massachusetts. Registration in BIOS 27710, 27711, and 27712, plus one of BIOS 27713, 27714, or 27715 is required. Admission to the Semester in Environmental Science program is by application, which must be received by the MBL in March of the year preceding the start of the semester. Admissions decisions will be mailed in April. Note that these courses start at the beginning of September, typically four weeks prior to the start of the College’s Autumn Quarter and are completed by the end of Autumn Quarter. More information on the course content and the application process can be found at https://college.uchicago.edu/academics/semester-environmental-science.

BIOS 27710. Ecology - Marine Biological Laboratory. 100 Units.

This course examines the structure and functioning of terrestrial and aquatic ecosystems including the application of basic principles of community and ecosystem ecology. The course also examines contemporary environmental problems such as the impacts of global and local environmental change on community composition and food webs within forest, grassland, marsh and nearshore coastal ecosystems on Cape Cod. This course examines the structure and functioning of terrestrial and aquatic ecosystems including the application of basic principles of community and ecosystem ecology. The course also examines contemporary environmental problems such as the impacts of global and local environmental change on community composition and food webs within forest, grassland, marsh and nearshore coastal ecosystems on Cape Cod.

Instructor(s): Marine Biological Laboratory Staff     Terms Offered: Autumn. L.
Prerequisite(s): Consent only. Admission by application to the Semester in Environmental Science program at the Marine Biological Laboratory in Woods Hole, MA; concurrent registration in BIOS 27711 and BIOS 27712 along with one of BIOS 27713, BIOS 27714 or BIOS 27715.
Note(s): E.
Equivalent Course(s): ENSC 24100

BIOS 27711. Biogeochemical Analysis in Terrestrial and Aquatic Ecosystems – Marine Biological Laboratory. 100 Units.

This course examines the interface of biological processes with chemical processes in ecological systems. Course content emphasizes aquatic chemistry and the role of microbes in the cycling of nitrogen, carbon, and other elements. Effects of global changes on chemical cycling are emphasized.

Instructor(s): Marine Biological Laboratory Staff.     Terms Offered: Autumn. L.
Prerequisite(s): Consent only. Admission by application to the Semester in Environmental Science program at the Marine Biological Laboratory in Woods Hole, MA; concurrent registration in BIOS 27710 and BIOS 27712 along with one of BIOS 27713, BIOS 27714 or BIOS 27715.
Note(s): E.
Equivalent Course(s): ENSC 23820

BIOS 27712. Independent Undergraduate Research in Environmental Sciences Marine Biological Laboratory. 100 Units.

This course is the culmination of the Semester in Environmental Science at the Marine Biological Laboratory. An independent research project, on a topic in aquatic or terrestrial ecosystem ecology, is required. Students will participate in a seminar for scientific communication as well as submit a final paper on their project.

Instructor(s): Marine Biological Laboratory Staff     Terms Offered: Autumn. L.
Prerequisite(s): Consent only. Admission by application to the Semester in Environmental Science program at the Marine Biological Laboratory in Woods Hole, MA; concurrent registration in BIOS 27710 and BIOS 27711 along with one of BIOS 27713, BIOS 27714 or BIOS 27715.
Note(s): E.
Equivalent Course(s): ENSC 29800

BIOS 27713. Quantitative Environmental Analyses – Marine Biological Laboratory. 100 Units.

This course emphasizes the application of quantitative methods to answering ecological questions. Students apply mathematical modeling approaches to simulating biological and chemical phenomena in terrestrial and marine ecosystems.

Instructor(s): Marine Biological Laboratory Staff     Terms Offered: Autumn. L.
Prerequisite(s): Consent Only. Admission by application to the Semester in Environmental Science program at the Marine Biological Laboratory in Woods Hole, MA; concurrent registration in BIOS 27710, BIOS 27711 and BIOS 27712.
Note(s): E.
Equivalent Course(s): ENSC 28100

BIOS 27714. Methods in Microbial Ecology - Marine Biological Laboratory. 100 Units.

This course explores the biology of microbes found in the environment, including relationships with the physical, chemical, and biotic elements of their environment. Emphasis is placed on understanding the science underlying the various methodologies used in the study of these organisms and systems. In the laboratory, students will work with the latest techniques to measure microbial biomass, activity, extracellular enzymes, and biogeochemical processes. Students are also introduced to molecular methods for assessing microbial genomic diversity.

Instructor(s): Marine Biological Laboratory Staff     Terms Offered: Autumn. L.
Prerequisite(s): Consent only. Admission by application to the Semester in Environmental Science program at the Marine Biological Laboratory in Woods Hole, MA; concurrent registration in BIOS 27710, BIOS 27711 and BIOS 27712.
Note(s): E.
Equivalent Course(s): ENSC 24200

BIOS 27715. Roles of Animals in Ecosystems – Marine Biological Laboratory. 100 Units.

This course addresses the question, How do animals, including man, affect the structure and function of ecosystems. The course takes an interdisciplinary approach focused on the interactions of animal diversity, migration patterns, population dynamics, and behavior with biogeochemical cycles, productivity, and transport of materials across ecosystems. This course is an elective option within the Semester in Environmental Science program at the Marine Biological Laboratory in Woods Hole, MA.

Instructor(s): Marine Biological Laboratory Staff     Terms Offered: Autumn
Prerequisite(s): Consent only. Admission by application to the Semester in Environmental Science program at the Marine Biological Laboratory in Woods Hole, MA; concurrent registration in BIOS 27710, BIOS 27711, and BIOS 27712.
Note(s): E.
Equivalent Course(s): ENSC 24300

BIOS 27720-27723-27725. SEPTEMBER COURSES AT MARINE BIOLOGICAL LABORATORY, WOODS HOLE.

The September courses combine lecture with hands-on learning and development of independent research ideas and projects. All are taught by University of Chicago or MBL faculty, and take advantage of the unique research strengths and the natural environmental resources found at MBL. These are intensive, three-week-long courses that meet for up to eight hours per day for 5–6 days per week, combining morning lectures with afternoon labs and fieldwork. Each student can only enroll in one course at a time. The September courses at MBL have no pre-requisites, and can count either to fulfill the general education requirement in Biology OR as an upper-level elective. Also offered in this program is HIPS 18507 Science, Culture, and Society III: From Natural History to Biomedicine. More information, including application details and program fees, can be found at https://college.uchicago.edu/academics/mbl-september-courses. The MBL September courses end before classes commence in Chicago.

BIOS 27720. Microbiomes Across Environments. 100 Units.

Microbiomes Across Environments provides a comprehensive introduction to microbiome research, tools and approaches for investigation, and a lexicon for biological understanding of the role of microbial communities in environmental and host environments. Microbiome science is an emerging field that bridges disciplines, merging microbiology with genomics, ecosystem science, computation, biogeochemistry, modeling, medicine and many others, including architecture, social science, chemistry and even economics. In this course we will uncover the vast biochemical and metabolic diversity of the microbial world by examining life in coastal and marine systems, (including) host-associated contexts. Students will develop or strengthen biological field/lab techniques, analyze and compare data prepared from student-collected samples, and will integrate fundamental knowledge, modeling, and theory as it pertains to microbiome research.

Instructor(s): D. Mark-Welch, E. L. Peredo.     Terms Offered: Summer. L. September term.
Note(s): This course will be given at Marine Biological Laboratory, Woods Hole, Massachusetts. E.GP.

BIOS 27723. Biodiversity and Genomics: Exploring the Marine Animal Diversity of Woods Hole Using Molecular Tools. 100 Units.

In this course, student will have the opportunity to explore the large diversity of marine animal species in Woods Hole, Massachusetts and its surroundings. We will combine fieldwork with genomic and bioinformatic approaches to study different aspects of the evolution, ecology, taxonomy, physiology, and biogeography of marine animals in this unique location. Student will integrate knowledge and analytical tools from different biological disciplines to develop short research projects. During the three weeks of the course, student will have access to the Marine Biological Laboratory's collection of living marine animals, participate in ongoing research projects at MBL, and contribute data that will advance our understanding of marine biodiversity.

Instructor(s): O. Pineda-Catalan     Terms Offered: Summer. L. September term.
Note(s): This course will be given at Marine Biological Laboratories, Woods Hole, Massachusetts. E.

BIOS 27725. Biogeography and Distribution of Species. 100 Units.

Students will explore various aspects of the biota of the region surrounding the Marine Biology Laboratory, Woods Hole, MA. The focus of the course will be to examine various patterns in the distribution and abundance of the flora/fauna in the islands and associated mainland habitats over the course of 3 weeks through a combination of in class lectures and laboratory sessions, combined with field studies. Penikese Island will receive special focus for extensive inventory of the biota, to update previous contributions to the flora of the island and begin an inventory of mammals, birds, and invertebrates. Similar surveys will be made of nearby mainland habitats for biogeographic comparisons between island and mainland patterns of abundance.

Instructor(s): Larsen, E.     Terms Offered: Summer. L. September term.
Note(s): This course will be given at Marine Biological Laboratories, Woods Hole, Massachusetts. E.

BIOS 27724-27750-27751. BIOLOGY SPRING QUARTER COURSES AT MARINE BIOLOGICAL LABORATORY.

These courses are part of an interdisciplinary four-course program given during Spring Quarter at the Marine Biological Laboratory in Woods Hole, Massachusetts. BIOS 20198 Biodiversity (Section 2) will also be offered in this program. The non-BIOS courses in this program are PHYS 12400 Waves, Optics, and Modern Physics at MBL and ARTV 10100 Visual Language: On Images. For more information, see https://college.uchicago.edu/academics/mbl-spring-quarter-biology.

BIOS 27724. Introduction to Imaging for Biological Research. 100 Units.

Many breakthroughs in science have been made possible by revolutionary advances in our ability to visualize biological processes, and recent progress in microscopy has led to important breakthroughs in understanding life at the molecular, cellular, and organismal level. In this course, we will introduce the students to basic techniques in microscopy, starting with an opportunity for students to build their own simple microscopes, and then proceeding all the way to using state-of-the-art confocal, light sheet, and electron microscopes. Students will explore the challenges of sample preparation, of imaging processes in living cells, and in the computational analysis of imaging data. Throughout the course, students will be able to design their own experiments, and undertake a student-designed research project.

Instructor(s): Wolff, C., Kerr, L.     Terms Offered: Spring
Prerequisite(s): Second-year standing or greater (or by consent).
Note(s): Course meets for three weeks, (5-6 days/week, 8 hours per day), at Marine Biological Laboratories, in Woods Hole Massachusetts as part of Spring quarter at MBL. For more information see https://college.uchicago.edu/academics/mbl-spring-quarter-biology
Equivalent Course(s): NSCI 21515

BIOS 27750. Stem Cells and Regeneration: from aquatic research organisms to mammals. 100 Units.

This course will focus on contemporary stem cell biology and regeneration with emphasis on molecular mechanisms and applications. The course will cover the history of stem cell discoveries through the latest advances, including genome-wide profiling, targeted gene editing, and other techniques used in stem cell and regeneration research. A portion of the course will consist of modules where specific stem cell types will be discussed together with relevant diseases they could impact (i.e. stem cells and neurodegeneration). A focus of the course will be around how discoveries in aquatic research organisms have driven the progress in regeneration biology. In this classroom and lab based course, students will have the opportunity to work on an independent research project under the supervision of a Resident Faculty at MBL. The lab portion of the course will introduce and provide hands-on experience on experimental approaches and techniques used in cell biology, development, and regeneration research. There will be a focus on microscopy (brightfield, fluorescence, high-resolution microscopy) and use of open source software to analyze images. There will be an introduction into the use of stains, antibodies, and genetically-encoded fluorescent markers to analyze cellular structures in aquatic organisms that include axolotls, Nematostella, worms, cephalopods and zebrafish. In addition, this course will provide hands-on experience through labs.

Instructor(s): K. Echeverri     Terms Offered: Spring
Prerequisite(s): Second-year standing or greater (or by consent).
Note(s): Course meets for three weeks. (5-6 days/wek, 8 hours per day) at Marine Biological Laboratories, in Woods Hole Massachusetts as part of the Spring Quarter at MBL. For more information see https://college.uchicago.edu/academics/mbl-spring-quarter-biology

BIOS 27751. Biological Oceanography. 100 Units.

This intensive four-week course addresses fundamental oceanographic processes that maintain and structure marine biodiversity and productivity, including physical oceanographic processes of dispersal and upwelling, environmental selection, biogeography, nutrient dynamics, primary production, and food web dynamics. Students will design an original research project during an initial week-long shore component at Marine Biological Laboratory (MBL) in Woods Hole, MA, and then address their own questions by collecting samples and data aboard Sea Education Association (SEA)'s oceanographic research sailing vessel, the SSV Corwith Cramer, on a 10-day offshore voyage. At sea students will deploy oceanographic instruments, interpret various data streams, and work as research teams and watch members as they navigate and sail the vessel. During a final week-long shore component at MBL, students will analyze and interpret the data they collected and present their results in written and oral reports.

Instructor(s): SEA Staff.     Terms Offered: Spring. MBL Spring Quarter- Biology. L.
Prerequisite(s): Second-year standing or greater (or by consent).
Note(s): Course meets for three weeks (5-6 days/week, 8 hours per day) at Marine Biological Laboratories, in Woods Hole Massachusetts as part of the Spring Quarter at MBL. For more information see https://college.uchicago.edu/academics/mbl-spring-quarter-biology E.
Equivalent Course(s): ENSC 25000

BIOS 27752. Dynamic Camouflage: Behavior, Visual Perception and Neural Skin Patterning in Cephalopods. 100 Units.

This course takes an integrative approach to understanding a neurally controlled system of dynamic defense against visual predators. Camouflage is a widespread form of defense throughout the animal kingdom in every known habitat - land or sea. In the oceans, cephalopods (cuttlefish, octopus, squid) have evolved a sophisticated sensorimotor system called Rapid Adaptive Coloration, which can instantaneously change their total body appearance within a fraction of a second to range from highly camouflaged to startlingly conspicuous for a wide range of behaviors. The forms and functions of this dynamic system will be teased apart in integrative fashion in a top-down approach from ecology to organismal biology to organs, tissues and cells. The course touches on neural anatomy, sensation, visual perception (including psychophysics) and animal behavior. There are also applied biology aspects of this system that will be presented as well.

Instructor(s): R. Hanlon     Terms Offered: Spring
Prerequisite(s): Acceptance into the MBL Neuroscience Spring Quarter Program
Equivalent Course(s): NSCI 21530

BIOS 27753. Fundamentals of Synapses. 100 Units.

In this course, students will learn about the fundamentals of synapses, from molecular analysis to structure and function. Marine and aquatic models have historically provided a unique opportunity to investigate synaptic function due to the large size of their neurons, including the synaptic connections. Today, these synapse models are used to study basic principles of neuron-to-neuron communication (synaptic transmission), as well as disease mechanisms. In addition to lectures and discussions of key literature, this course will feature hands-on laboratory-based exercises in molecular genetics, imaging and physiology of synapses, as well as independent "discovery" projects to explore new topics in synapse biology.

Instructor(s): J. Morgan, J. Rosenthal     Terms Offered: Spring
Prerequisite(s): Acceptance into a Spring Quarter program at MBL
Equivalent Course(s): NSCI 21510

BIOS 27760. An Introduction to Parasitology. 100 Units.

This course introduces the diversity of parasitic organisms, both protozoan and metazoan, and explores the life cycles, morphology, genomics, pathology, immunology, epidemiology, and treatment and control of major parasite groups. The focus will be on aquatic species, including those that cause disease in humans and livestock. The course will involve lectures, a journal club and lab work including carrying out a research project. The lab work and research project will include working on parasitic flatworms; in particular investigating the molecular and cellular biology of a tropical species, Schistosoma mansoni, that is medically important. Here, in this research-led institute, you will contribute novel data and information to ongoing research at MBL that will advance our understanding of parasites. The lab portion will introduce the morphological and molecular techniques that form part of the toolkit used by parasitologists to understand the biology of these organisms, an essential step in the search and development of novel control strategies and therapeutics.

Instructor(s): K. Rawlinson     Terms Offered: TBD
Note(s): Offered at The Marine Biological Laboratory in Woods Hole, MA.

BIOS 27810. Epidemiology and Population Health: Global Health Sciences I. 100 Units.

Epidemiology is the basic science of public health. It is the study of how diseases are distributed across populations and how one designs population-based studies to learn about disease causes, with the object of identifying preventive strategies. Epidemiology is a quantitative field and draws on biostatistical methods. Historically, epidemiology's roots were in the investigation of infectious disease outbreaks and epidemics. Since the mid-twentieth century, the scope of epidemiologic investigations has expanded to a fuller range of non-infectious diseases and health problems. This course will introduce classic studies, study designs, and analytic methods, and will include articles that approach epidemiology from the global context.

Instructor(s): D. Lauderdale.     Terms Offered: Autumn
Prerequisite(s): Completion of the three quarters of a Biological Sciences Fundamentals Sequence and completion of the quantitative requirements for the Biological Sciences Major. STAT 22000 or other introductory statistics highly desirable.

BIOS 27813. Cancer Concepts: Causes and Consequences. 100 Units.

The goal of this course is to build concepts and develop understanding of how cancers arise by addressing the genetic basis of cancer, in addition to the role of environmental stresses in tumorigenesis. Specifically, we will examine how genetic changes, infection, diet and stress all affect tumor cell stemness, tumor evolution & heterogeneity, tumor metabolism and drug resistance. We will focus in on the role of the human papillomavirus (HPV) in humans cancers as a means to dissect basic molecular mechanisms of cancer but also to explore how our understanding of HPV as an etiological factor in cancer has changed in recent years, how efforts to vaccinate against HPV serves as a paradigm (or not) for other cancers and the controversies surrounding all of the above. Finally, we will examine in more detail how obesity, altered metabolism and stress affect tumor metabolism, co-evolution of the tumor with its microenvironment, the gut microbiome and anti-tumor immunity, and how diet may be exploited to prevent cancers (or not). We will conclude with a discussion of possible future directions to better prevent and treat human cancers.

Instructor(s): K. Macleod     Terms Offered: Winter. This course is offered in Paris, for more information see: https://study-abroad.uchicago.edu/paris-global-health
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals sequence including BIOS 20187 or BIOS 20235, or consent of Instructor.
Note(s): GP.

BIOS 27815. Infectious Diseases. 100 Units.

This course will examine infectious diseases with global health impact, analyzing their historic and projected impact, biological foundations, and preventive control. Course topics include gastrointestinal infections (e.g., cholera, bacillary dysentery, typhoid fever, rotavirus infections), sexually transmitted diseases (HIV), infections transmitted via aerosol droplets (tuberculosis, meningitis), and vector borne diseases (e.g., malaria, typhus, dengue fever, plague). Special emphasis will be placed on emerging infectious diseases (Ebola, Coronavirus) and the role of vaccines and other strategies for infectious disease elimination (smallpox, polio, malaria, river blindness). The course encompasses lectures and student presentations. Students have the option to write a paper in lieu of a final exam

Instructor(s): Beavis, K; Tesic, V.      Terms Offered: Winter. Not offered Winter 2024
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals Sequence or consent of instructor.
Note(s): This course is offered in Paris. For more information see: https://study-abroad.uchicago.edu/paris-global-health

BIOS 27816. Population Biology of Infectious Diseases of Global Health Concern. 100 Units.

This course is designed for students interested in pursuing careers in public health, global health, infectious disease modeling, or related disciplines. The aim of the course is to introduce students to the population biology of infectious diseases, in particular the use of dynamical transmission models in understanding and controlling diseases of global health concern. This is complementary to a classic epidemiological and biostatistical approach to infectious disease intervention. The course will take place during the Winter Quarter Study Abroad track at the University of Chicago Paris Center, which has a focus on the Global Health Sciences. In this course, students will learn how to understand, explain, and construct simple SIR models in the programming language R and use these models to interrogate dynamical research questions about diseases of interest, in particular those of global public health concern (HIV, TB, malaria, rabies, schistosomiasis, cholera). Students will also be introduced to the field of molecular epidemiology and viral phylodynamics and learn how to apply relevant techniques to understand and control disease transmission.

Instructor(s): C. Brook     Terms Offered: Winter. Winter Quarter Study Abroad in Paris: Global Health.
Prerequisite(s): Paris Program: Global Health. BIOS 20153 & BIOS 20151 & MATH 13100-13200 or equivalent. Prior experience programming in R (or any other language) is helpful but not required. Enrollment without the above prerequisites may be permitted with prior consent of the instructor.
Note(s): GP

BIOS 28101-28102. Science Communication.

The ability to communicate the importance, excitement, and rigor of science to the general public is a critical skill for scientists. By translating scientific research scientists can, among other things, shape public policy, create an informed voting population, and encourage funding for research. In these three courses, open to third- and fourth-year undergraduates, students will critically analyze different communication strategies and practice communicating science through assignments and interactive skill-building sessions. In BIOS 28101, students will translate primary research into written story form and publish their work on a digital platform. In BIOS 28102, students will communicate primary research by creating a TED Talk–style video. Students can take a single course or both courses. Either BIOS 28101 or BIOS 28102 (but not both) can be applied toward a major in Biological Sciences.

BIOS 28101. Science Communication: Writing a Digital Science Story. 100 Units.

Students will gain skills in written and digital communication, focusing on translating primary scientific research to a general audience. Students will learn what makes an engaging written article and how to write for the public without sacrificing scientific accuracy or complexity. We will explore platforms such as newspapers, magazines, blogs and social media. Students will work with faculty mentors to complete two written pieces that communicate research findings and their significance to a general audience. Student articles may be disseminated on the websites of the Illinois Science Council, Marine Biology Laboratory, the Institute for Translational Medicine, or the National Institutes of Health. Students will walk away with a polished, published work.

Instructor(s): S. Serritella, P. Mason     Terms Offered: Autumn
Prerequisite(s): Three quarters of physical or biological (including neuroscience) sciences. Third- or fourth-year standing. This course does not satisfy the general education requirement in the physical sciences.
Equivalent Course(s): SCPD 11100, PHSC 28101

BIOS 28102. Science Communication: Producing a Science Video Story. 100 Units.

Students will gain skills in oral communication and will apply these skills to produce a TED Talk-style video communicating primary research in a scientific area of the student's choice. The goal is effective, engaging communication of science to a general audience without sacrificing scientific accuracy or complexity. Students will work with faculty to write scripts and design visual and audio elements. The talks will be filmed and edited in collaboration with UChicago Creative, who will assist with visual aids and animation. Students will leave the course with a professionally produced video that they can use to advance their career and promote their topic. While this course naturally follows BIOS 28101, that course is not a pre-requisite.

Instructor(s): P. Mason, S. Serritella      Terms Offered: Spring. Spring 2022.
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals sequence. Third- or fourth-year standing. This course does not satisfy the general education requirement in the physical sciences.
Equivalent Course(s): SCPD 11200, PHSC 28102

BIOS 28407. Genomics and Systems Biology. 100 Units.

This lecture course explores technologies for high-throughput collection of genomic-scale data, including sequencing, genotyping, gene expression profiling, and assays of copy number variation, protein expression and protein-protein interaction. In addition, the course will cover study design and statistic analysis of large data sets, as well as how data from different sources can be used to understand regulatory networks, i.e., systems. Statistical tools that will be introduced include linear models, likelihood-based inference, supervised and unsupervised learning techniques, methods for assessing quality of data, hidden Markov models, and controlling for false discovery rates in large data sets. Readings will be drawn from the primary literature. Evaluation will be based primarily on problem sets.

Instructor(s): Y. Gilad     Terms Offered: Spring
Prerequisite(s): Three quarters of a Biological Sciences Fundamentals sequence including BIOS 20187 or BIOS 20235 and STAT 23400 or BIOS 26210 and BIOS 26211
Note(s): CB.
Equivalent Course(s): IMMU 47300, BPHS 47300, HGEN 47300, CABI 47300

BIOS 28411. Quantitative Systems Biology. 100 Units.

This course aims to provide students with knowledge on the use of modern methods for the analysis, manipulation, and modeling of complex biological systems, and to introduce them to some of the most important applications in quantitative and systems biology. We will first survey theoretical concepts and tools for analysis and modeling of biological systems like biomolecules, gene networks, single cells, and multicellular systems. Concepts from information theory, biochemical networks, control theory, and linear systems will be introduced. Mathematical modeling of biological interactions will be discussed. We will then survey quantitative experimental methods currently used in systems biology. These methods include single cell genomic, transcriptomic, and proteomic analysis techniques, in vivo and in vitro quantitative analysis of cellular and molecular interactions, single molecule methods, live cell imaging, high throughput microfluidic analysis, and gene editing. Finally, we will focus on case studies where the quantitative systems approach made a significant difference in the understanding of fundamental phenomena like signaling, immunity, development, and diseases like infection, autoimmunity, and cancer.

Instructor(s): Savas Tay     Terms Offered: Autumn
Prerequisite(s): Completion of the first two quarters of a Biological Sciences Fundamentals Sequence
Equivalent Course(s): MENG 22300, MENG 32300

BIOS 28700. Biodiagnostics and Biosensors. 100 Units.

This course focuses on the biological and chemical interactions that are important for the diagnosis of diseases and the design of new assays. The principles and mechanisms of molecular diagnostics and biosensors, as well as their applications in disease diagnosis, will be discussed. Bioanalytical methods including electrochemical, optical, chemical separation, and spectroscopic will be described. Surface functionalization and biomolecular interactions will be presented for the development of protein and DNA based biosensor applications. The goals for the course are to introduce the fundamental mechanisms of bioanalytical methods/tools, examples of specific methods for diagnostic purposes, and analytical methods necessary for developing new precision medicine tools.

Instructor(s): Mustafa Guler      Terms Offered: Spring
Prerequisite(s): Completion of the first two quarters of a Biological Sciences Fundamentals Sequence
Equivalent Course(s): MENG 33140, MENG 23140

BIOS 28900. Undergraduate Bachelor of Science Research. 100 Units.

Students who are completing the Biological Sciences major with a BS degree must register for this course in the autumn of the fourth year (see guidelines at https://college.uchicago.edu/academics/bs-guidelines-and-timeline) unless they are enrolled in the research course for the BSCD Honors program (BIOS 00296. Undergraduate Honors Research.) We will hold five mandatory evening sessions in Autumn Quarter and five mandatory evening sessions in Winter Quarter. Participants will give short presentations on their thesis research during these evening sessions. Students will receive a quality grade for the course upon submission of an approved BS thesis in Spring Quarter. BIOS 28900 can be counted as one upper-level elective toward the Biological Sciences major and may be counted among the three upper-level courses required for the BS.

Instructor(s): C. Andrews     Terms Offered: Autumn
Prerequisite(s): Students must be Biological Sciences majors pursuing the BS degree. This course is not open to students in the BSCD Honors program who are enrolled in BIOS 00296. (Undergraduate Honors Research).

Big Problems Courses

The following two courses are part of the Big Problems Curriculum franke.uchicago.edu/big-problems-courses.

BIOS 02280. Drinking Alcohol: Social Problem or Normal Cultural Practice? 100 Units.

Alcohol is the most widely used psychoactive agent in the world, and, as archaeologists have recently demonstrated, it has a very long history dating back at least 9,000 years. This course will explore the issue of alcohol and drinking from a trans-disciplinary perspective. It will be co-taught by an anthropologist/archaeologist with experience in alcohol research and a neurobiologist who has experience with addiction research. Students will be confronted with literature on alcohol research from anthropology, sociology, history, biology, medicine, psychology, and public health and asked to think through the conflicts and contradictions. Selected case studies will be used to focus the discussion of broader theoretical concepts and competing perspectives introduced in the first part of the course. Topics for lectures and discussion include: fermentation and the chemistry and pharmacology of alcohol; the early history of alcohol; histories of drinking in ancient, medieval, and modern times; alcohol and the political economy; alcohol as a cultural artifact; styles of drinking and intoxication; how is alcohol metabolized; addiction; how does alcohol affect sensations; social problems; alcohol and religion; alcohol and health benefits; comparative case studies of drinking.

Instructor(s): M. Dietler, W. Green     Terms Offered: Winter
Prerequisite(s): Third or fourth-year standing.
Note(s): This course does not meet requirements for the biological sciences major.
Equivalent Course(s): ANTH 25310, BPRO 22800, HLTH 25310

BIOS 02490. Biology and Sociology of AIDS. 100 Units.

This interdisciplinary course deals with current issues of the AIDS epidemic.

Instructor(s): H. Pollack, J. Schneider     Terms Offered: Not offered in 2023-2024
Prerequisite(s): Third- or fourth-year standing
Note(s): This course does not meet requirements for the biological sciences major.
Equivalent Course(s): SSAD 65100, BPRO 24900

Specialized Courses

These courses may not be used as upper-level electives in the Biological Sciences major, nor can they be used to satisfy the general education requirement in the biological sciences, unless otherwise indicated in the course description or approved through petition to the BSCD Senior Advisors. They may count as upper-level electives in certain Interdisciplinary Biology Tracks. 

BIOS 29326. Introduction to Medical Physics and Medical Imaging. 100 Units.

This course covers the interaction of radiation with matter and the exploitation of such interactions for medical imaging and cancer treatment. Topics in medical imaging include X-ray imaging and radionuclide imaging, as well as advanced technologies that provide three-dimensional images, including X-ray computed tomography (CT), single photon emission computed tomography (SPECT), positron emission tomography (PET), magnetic resonance imaging (MRI), and ultrasonic imaging.

Instructor(s): S. Armato, P. La Riviere     Terms Offered: Spring
Prerequisite(s): PHYS 23500. This course does not meet requirements for the Biological Sciences major. Students majoring in physics may use this course either as an elective or as one of the topics courses to meet the general education requirement in the Biological Sciences.
Equivalent Course(s): MPHY 29326

BIOS 29814. Biological and Social Determinants of Health. 100 Units.

Global health is an interdisciplinary and empirical field, requiring holistic and innovative approaches to navigate an ever-changing environment in the pursuit of health equity. This course will emphasize specific health challenges facing vulnerable populations in low resource settings including in the United States and the large scale social, political, and economic forces that contribute to them through topical events and case studies. Students will study the importance of science and technology, key institutions and stakeholders; environmental impacts on health; ethical considerations in research and interventions; maternal and child health; health and human rights; international legal frameworks and global health diplomacy. Students will gain skills in technical writing as they construct position statements and policy briefs on global health issues of interest. Career opportunities in global health will be explored throughout the course.

Instructor(s): C. Olopade, K. Beavis      Terms Offered: Winter. This course is offered every Winter quarter in Paris.
Prerequisite(s): BIOS 27810 or consent of instructor.
Note(s): This course counts towards the Biological Sciences major ONLY for students in the Global & Public Health Track.
Equivalent Course(s): CCTS 42003, CCTS 22003

Independent Study and Research Courses

BIOS 00199-00299

Students pursuing independent research in the lab of a Biological Sciences Division faculty member may obtain credit by enrolling in the following courses. These courses cannot be counted toward the major in Biological Sciences.

BIOS 00199. Undergraduate Research. 100 Units.

This course may be elected for up to three quarters. Before Friday of fifth week of the quarter in which they register, students must submit a one-page summary of the research that they are planning to their research sponsor and to the director of undergraduate research and honors. A detailed two to three page summary on the completed work must be submitted to the research sponsor and the Master of BSCD before Friday of examination week.

Instructor(s): BSCD Master     Terms Offered: Autumn,Spring,Summer,Winter
Prerequisite(s): Consent of research sponsor and the Master of BSCD.
Note(s): Students are required to submit the College Reading and Research Course Form. This course is graded P/F. This course does not meet requirements for the biological sciences major.

BIOS 00206. Readings: Biology. 100 Units.

Students may register for only one BIOS 00206 tutorial per quarter. Enrollment must be completed by the end of the second week of the quarter. This tutorial offers individually designed readings.

Terms Offered: Summer,Autumn,Winter,Spring
Prerequisite(s): Consent of faculty sponsor
Note(s): Students are required to submit the College Reading and Research Course Form. This course is graded P/F. This course does not meet requirements for the biological sciences major.

BIOS 00296. Undergraduate Honors Research. 100 Units.

This course is required for students accepted into the BSCD Research Honors program. Students must register for this course both Autumn and Winter Quarters of their fourth year. This course can be counted toward the Biological Sciences major and may be counted among the three upper-level courses required for the BS. See also bscd.uchicago.edu/page/honors-biology. Quality grade. Prerequisite(s): Consent Only. Acceptance in BSCD Honors Research Program.

Instructor(s): S. Kron     Terms Offered: Autumn,Winter
Prerequisite(s): Consent Only. Acceptance in BSCD Honors Research Program.

BIOS 00299. Advanced Research: Biological Sciences. 100 Units.

Before Friday of fifth week of the quarter in which they register, students must submit a one-page summary of the research that they are planning to their research sponsor and to the director of undergraduate research and honors. A detailed two to three page summary on the completed work must be submitted to the research sponsor and the Master of BSCD before Friday of examination week. This course does may be counted as a general elective but does not meet requirements for the Biological Sciences major. In the first quarter of registration, students must submit College Reading and Research form to their research sponsor and the director of undergraduate research and honors.

Instructor(s): BSCD Master     Terms Offered: Autumn,Spring,Summer,Winter
Prerequisite(s): Fourth-year standing and consent of research sponsor and Master of BSCD.
Note(s): Students are required to submit the College Reading and Research Course Form. This course is graded P/F.

Graduate-Level Courses

Many graduate-level courses in the Division of the Biological Sciences are open to qualified College students. Students should consult their advisers, the BSCD office, or the various departments and committees in the division to identify appropriate courses.


Contacts

Chair

BSCD Master
Jocelyn Malamy
BSLC 300
773.702.9270
Email

Undergraduate Primary Contacts

Senior Adviser
Chris Andrews
BSLC 306
773.702.1214
Email

Senior Adviser
Megan McNulty
BSLC 304
773.834.7744
Email

Administrative Contacts

Division Administrator
Kila Roberts
BSLC 328
773.702.7962
Email

Manager of Technology
Kris McDonald
BSLC 312
773.702.4937
Email

Secondary Contacts

Laboratory Manager
Tristan M. Clark
BSLC 336
773.702.1930
Email

Undergraduate Research and Honors
D. Allan Drummond
GCIS W234
773.834.2017
Email

Undergraduate Research
Paul Strieleman
BSLC 338
773.702.5076
Email

Preceptors/BA Advisors

Faculty Adviser, Cancer Specialization
Kay Macleod
GCIS W-338
773.834.8309
Email

Faculty Advisor, Developmental Biology Specialization
Akira Imamoto
GCIS W332
773.834.1258
Email

Faculty Adviser, Endocrinology Specialization
Matthew Brady
KCBD 8124
773.702.2346
Email

Faculty Adviser, Immunology Specialization
Daria Esterhazy

773.702.0402
Email

Faculty Adviser, Microbiology Specialization
Dominique Missiakas
HTRL, Argonne National Laboratory
773.842.2627
Email

Ecology and Evolution Track Co-Director
Cathy Pfister
Z401A
773.834.0071
Email

Ecology and Evolution Track Co-Director
Chris Andrews
BSLC 306
773.702.21214
Email

Global and Public Health Track Director
Kathleen Beavis
5841 S. Maryland Ave., MC 0001
773.702.3689
Email

Computational Biology Track Co-Director
Anindita Basu
5841 S. Maryland Ave., N417B
773.834.1512
Email

Computational Biology Track Co-Director
Dmitry Kondrashov
BSLC 301A
773.834.3387
Email